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    allo-1 Allophagy receptor allo-1 [ Caenorhabditis elegans ]

    Gene ID: 177962, updated on 9-Dec-2024

    Summary

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    Official Symbol
    allo-1
    Official Full Name
    Allophagy receptor allo-1
    Primary source
    WormBase:WBGene00011292
    Locus tag
    CELE_R102.5
    See related
    AllianceGenome:WB:WBGene00011292
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein homodimerization activity. Involved in autophagosome assembly and regulation of autophagy. Located in cytoplasm. Is expressed in oocyte. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See allo-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (10695306..10697072, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene TransThyretin-Related family domain Neighboring gene Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein;Beta_elim_lyase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene MARVEL domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ALLO-1- and IKKE-1-dependent positive feedback mechanism promotes the initiation of paternal mitochondrial autophagy. Sasaki T, et al. Nat Commun, 2024 Feb 17. PMID 38368448, Free PMC Article
    2. The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans. Sato M, et al. Nat Cell Biol, 2018 Jan. PMID 29255173
    3. Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins. Chen Y, et al. BMC Biotechnol, 2007 Jul 30. PMID 17663785, Free PMC Article
    4. SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity. Lim CY, et al. Autophagy, 2023 Jan. PMID 35503435, Free PMC Article
    5. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It has been proposed that ALLO-1 is the allophagy receptor whose function is regulated by IKKE-1-dependent phosphorylation.
      Title: The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in sarcomere HDA PubMed 
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    Allophagy receptor allo-1
    NP_501980.2
    • Confirmed by transcript evidence
    NP_501981.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10695306..10697072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069579.6 → NP_501980.2  Allophagy receptor allo-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501980.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21891, Q9U389
      Conserved Domains (1) summary
      COG4372
      Location:144 → 378
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

    2. NM_069580.7 → NP_501981.2  Allophagy receptor allo-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501981.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21891
      Conserved Domains (1) summary
      COG4372
      Location:144 → 380
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U389.2

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