Adcyap1r1 ADCYAP receptor type I [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adcyap1r1provided by RGD
Official Full Name: ADCYAP receptor type Iprovided by RGD
Primary source: RGD:2038
See related: EnsemblRapid:ENSRNOG00000012098 AllianceGenome:RGD:2038
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PAC1-R; PACAPR1; PACAP-R1; PACAPR1A; PACAP-R1A
Summary: Enables adenylate cyclase binding activity; neuropeptide binding activity; and small GTPase binding activity. Involved in several processes, including cAMP/PKA signal transduction; positive regulation of inositol phosphate biosynthetic process; and positive regulation of intracellular signal transduction. Located in several cellular components, including bicellular tight junction; caveola; and cell surface. Biomarker of cystitis. Orthologous to human ADCYAP1R1 (ADCYAP receptor type I). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 151.1), Adrenal (RPKM 30.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (85924171..85972973)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (84593558..84642700)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (85662809..85711696)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia, Substantia Nigra and Centrally Projecting Edinger-Westphal Nucleus in the Rotenone model of Parkinson's Disease.
Title: Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia, Substantia Nigra and Centrally Projecting Edinger-Westphal Nucleus in the Rotenone model of Parkinson's Disease.
PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
Title: PAC(1), VPAC(1), and VPAC(2) Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
Pituitary adenylate cyclase-activating polypeptide type 1 receptor within the nucleus accumbens core mediates excessive alcohol drinking in alcohol-preferring rats.
Title: Pituitary adenylate cyclase-activating polypeptide type 1 receptor within the nucleus accumbens core mediates excessive alcohol drinking in alcohol-preferring rats.
Pituitary adenylate cyclase-activating polypeptide receptor activation in the hypothalamus recruits unique signaling pathways involved in energy homeostasis.
Title: Pituitary adenylate cyclase-activating polypeptide receptor activation in the hypothalamus recruits unique signaling pathways involved in energy homeostasis.
PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache?
Title: PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache?
we examined the direct effects of PACAP on dentate gyrus (DG) granule cells in brain slices using whole cell patch recordings in current clamp mode. PACAP significantly increased the intrinsic excitability of DG granule cells via PAC1 receptor activation.
Title: Pituitary adenylate cyclase-activating polypeptide-induced PAC1 receptor internalization and recruitment of MEK/ERK signaling enhance excitability of dentate gyrus granule cells.
This study demonstrated that the hypothalamic PAC1 mRNA expression level fell after 24 h fasting in male rats, but no such changes were observed in the females.
Title: Developmental changes in the hypothalamic mRNA expression levels of PACAP and its receptor PAC1 and their sensitivity to fasting in male and female rats.
Compared to the rats in the control group, the rats in the HF group had the expression levels of 12 genes with significant changes, Agrp, Ghrl, and Nr3c1, Apoa4, Cntf, Ghr, IL-1beta, Ins1, Lepr,Sort, Adcyap1r1 and Adrb1.
Title: Green tea polyphenols reduce body weight in rats by modulating obesity-related genes.
PACAP-38 cause release of CGRP from trigeminal nucleus caudalis but not from trigeminal ganglia but not via activation of PAC1.
Title: PACAP-38 but not VIP induces release of CGRP from trigeminal nucleus caudalis via a receptor distinct from the PAC1 receptor.
PAC1-R-immunoreactive structures appearing from postnatal day 5 (P5) to P10 in the rat retina, are described..
Title: PAC1-expressing structures of neural retina alter their PAC1 isoform splicing during postnatal development.

Submit: New GeneRIF Correction See all GeneRIFs (31)

General gene information

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Markers

AI846590 (e-PCR)
- UniSTS:164324

Adcyap1r1 (e-PCR), detects polymorphism
- UniSTS:546535

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase binding	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables pituitary adenylate cyclase-activating polypeptide receptor activity	ISO Inferred from Sequence Orthology more info
enables pituitary adenylate cyclase-activating polypeptide receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables pituitary adenylate cyclase-activating polypeptide receptor activity	TAS Traceable Author Statement more info
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables vasoactive intestinal polypeptide receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP/PKA signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in development of primary female sexual characteristics	IEP Inferred from Expression Pattern more info	PubMed
involved_in multicellular organismal response to stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cAMP/PKA signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion transport into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of small GTPase mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pituitary adenylate cyclase-activating polypeptide type I receptor

Names: ADCYAP receptor type 1; PACAP type I receptor; PACAP type IA receptor; PACAP-R-1; PACAP-R-1A; adenylate cyclase activating polypeptide 1 (pituitary) receptor type I; adenylate cyclase activating polypeptide 1 receptor 1; adenylate cyclase activating polypeptide 1 receptor type 1; adenylate cyclase activating polypeptide 1 type 1 receptor; pituitary adenylate cyclase activating polypeptide 1 receptor (1); pituitary adenylate cyclase activating polypeptide receptor; pituitary adenylate cyclase-activating polypeptide type IA receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270579.1 → NP_001257508.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform a precursor

See identical proteins and their annotated locations for NP_001257508.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

CR475040, D16465, JAXUCZ010000004, Z23272

UniProtKB/Swiss-Prot

P32215, Q63414

UniProtKB/TrEMBL

A0A8I5ZUV4, A6K0Y6

Related

ENSRNOP00000016175.3, ENSRNOT00000016175.7

Conserved Domains (3) summary

pfam02793
Location:51 → 136

HRM; Hormone receptor domain

cd14964
Location:151 → 176

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:149 → 472

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001270580.1 → NP_001257509.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform c precursor

See identical proteins and their annotated locations for NP_001257509.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant (1). The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

CR475040, D16465, JAXUCZ010000004, Z23273

UniProtKB/TrEMBL

A0A8I6GIB0, A6K0Y9

Related

ENSRNOP00000050048.2, ENSRNOT00000046192.6

Conserved Domains (2) summary

pfam00002
Location:149 → 423

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:51 → 136

HRM; Hormone receptor domain
NM_001270581.1 → NP_001257510.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform d precursor

See identical proteins and their annotated locations for NP_001257510.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons and differs in the 5' UTR compared to variant (1). The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a. Variants 4 and 5 both encode the same isoform (d).

Source sequence(s)

CR475040, D14908, D16465, JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I6GIB0, A6K0Z5

Related

ENSRNOP00000044267.2, ENSRNOT00000043851.5

Conserved Domains (2) summary

cd15987
Location:149 → 416

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:51 → 136

HRM; Hormone receptor domain
NM_001270582.1 → NP_001257511.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform d precursor

See identical proteins and their annotated locations for NP_001257511.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks two alternate in-frame exons compared to variant (1). The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a. Variants 4 and 5 both encode the same isoform (d).

Source sequence(s)

CR475040, D16465, JAXUCZ010000004, Z23279

UniProtKB/TrEMBL

A0A8I6GIB0, A6K0Z5

Conserved Domains (2) summary

cd15987
Location:149 → 416

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:51 → 136

HRM; Hormone receptor domain
NM_001270583.1 → NP_001257512.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform e precursor

See identical proteins and their annotated locations for NP_001257512.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant (1). The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

CR475040, D16465, JAXUCZ010000004, Z23275

UniProtKB/TrEMBL

A0A8I6GIB0

Conserved Domains (2) summary

pfam00002
Location:149 → 422

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:51 → 136

HRM; Hormone receptor domain
NM_133511.2 → NP_598195.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform b precursor

See identical proteins and their annotated locations for NP_598195.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant (1). The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

CR475040, D16465, JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I6GIB0, A6K0Z2

Related

ENSRNOP00000030759.2, ENSRNOT00000035722.6

Conserved Domains (2) summary

pfam00002
Location:149 → 423

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:51 → 136

HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

85924171..85972973

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285463.1 → XP_063141533.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1

UniProtKB/TrEMBL

A0A8I5ZUV4
XM_039106996.2 → XP_038962924.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X3

UniProtKB/TrEMBL

A0A8I6GIB0

Conserved Domains (2) summary

cd15987
Location:173 → 468

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:51 → 160

HRM; Hormone receptor domain
XM_039106999.2 → XP_038962927.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X4

UniProtKB/TrEMBL

A0A8I6GIB0

Conserved Domains (2) summary

cd15987
Location:173 → 467

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:51 → 160

HRM; Hormone receptor domain
XM_039107000.2 → XP_038962928.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X7

UniProtKB/TrEMBL

A0A8I6GIB0

Conserved Domains (2) summary

cd15987
Location:173 → 440

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:51 → 160

HRM; Hormone receptor domain
XM_063285466.1 → XP_063141536.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X2

UniProtKB/TrEMBL

A0A8I5ZUV4
XM_063285467.1 → XP_063141537.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X5

UniProtKB/TrEMBL

A0A8I5ZUV4

Related

ENSRNOP00000082399.1, ENSRNOT00000103561.2
XM_063285464.1 → XP_063141534.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1

UniProtKB/TrEMBL

A0A8I5ZUV4
XM_063285465.1 → XP_063141535.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1

UniProtKB/TrEMBL

A0A8I5ZUV4
XM_063285468.1 → XP_063141538.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X6

UniProtKB/TrEMBL

A0A8I6GIB0, A6K0Z2
XM_063285469.1 → XP_063141539.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X8

UniProtKB/TrEMBL

A0A8I6GIB0, A6K0Z5