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    Prim1 DNA primase subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246327, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prim1provided by RGD
    Official Full Name
    DNA primase subunit 1provided by RGD
    Primary source
    RGD:621380
    See related
    EnsemblRapid:ENSRNOG00000086012 AllianceGenome:RGD:621380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA primase activity; metal ion binding activity; and ribonucleotide binding activity. Predicted to be involved in DNA replication initiation and DNA replication, synthesis of primer. Predicted to be part of alpha DNA polymerase:primase complex. Orthologous to human PRIM1 (DNA primase subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 217.4), Spleen (RPKM 152.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prim1 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1031436..1047134)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (446342..462526)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2435524..2451169)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555838 Neighboring gene 17-beta-hydroxysteroid dehydrogenase type 6-like Neighboring gene transfer RNA proline (anticodon GGG) Neighboring gene nascent polypeptide associated complex subunit alpha Neighboring gene prostaglandin E synthase 3 Neighboring gene uncharacterized LOC120093524

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression, purification, and characterization of the two human primase subunits and truncated complexes from Escherichia coli. Copeland WC. Protein Expr Purif, 1997 Feb. PMID 9116489
    2. A mutation in subunit B of the DNA polymerase alpha-primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase alpha-primase complex. Popanda O, et al. Mol Carcinog, 2001 Aug. PMID 11536367
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC109113

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA primase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA primase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA primase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication, synthesis of primer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication, synthesis of primer ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha DNA polymerase:primase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA primase small subunit
    Names
    DNA primase small subunit, 49kDa
    DNA primase, p49 subunit
    primase (DNA) subunit 1
    primase, DNA, polypeptide 1
    XP_038934350.2
    XP_038934351.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008768.4 → NP_001008768.3  DNA primase small subunit isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      Q5M832

    2. NM_001304365.3 → NP_001291294.3  DNA primase small subunit isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      O89045
      Related
      ENSRNOP00000094606.2, ENSRNOT00000100470.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1031436..1047134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078422.2 → XP_038934350.2  DNA primase small subunit isoform X1

      UniProtKB/TrEMBL
      O89045

    2. XM_039078423.2 → XP_038934351.2  DNA primase small subunit isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.