Mybbp1a MYB binding protein 1a [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mybbp1aprovided by RGD
Official Full Name: MYB binding protein 1aprovided by RGD
Primary source: RGD:62062
See related: EnsemblRapid:ENSRNOG00000015236 AllianceGenome:RGD:62062
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DBP
Summary: Enables sequence-specific DNA binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; positive regulation of anoikis; and regulation of gene expression. Predicted to act upstream of with a negative effect on regulation of G1 to G0 transition. Predicted to act upstream of or within respiratory electron transport chain. Predicted to be located in cytoplasm and nucleus. Predicted to be part of B-WICH complex and NLS-dependent protein nuclear import complex. Predicted to be active in nucleolus. Orthologous to human MYBBP1A (MYB binding protein 1a). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 218.6), Adrenal (RPKM 217.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (57555458..57565819)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (57056897..57067258)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (59000400..59010794)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH125539 (e-PCR)
- UniSTS:162354

RH136313 (e-PCR)
- UniSTS:210305

RH128336 (e-PCR)
- UniSTS:211644

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables E-box binding	IEA Inferred from Electronic Annotation more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of anoikis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase III	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of G1 to G0 transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_negative_effect regulation of G1 to G0 transition	ISO Inferred from Sequence Orthology more info
involved_in respiratory electron transport chain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory electron transport chain	ISO Inferred from Sequence Orthology more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of B-WICH complex	IEA Inferred from Electronic Annotation more info
part_of B-WICH complex	ISO Inferred from Sequence Orthology more info
part_of NLS-dependent protein nuclear import complex	IEA Inferred from Electronic Annotation more info
part_of NLS-dependent protein nuclear import complex	ISO Inferred from Sequence Orthology more info
part_of NLS-dependent protein nuclear import complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: myb-binding protein 1A

Names: MYB binding protein (P160) 1a; PAR-interacting protein; PIP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031668.2 → NP_113856.2 myb-binding protein 1A

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

O35821

UniProtKB/TrEMBL

A6HGF6

Related

ENSRNOP00000021134.2, ENSRNOT00000021134.5

Conserved Domains (2) summary

pfam04931
Location:70 → 833

DNA_pol_phi; DNA polymerase phi

NF033756
Location:1168 → 1255

gliding_GltC; adventurous gliding motility protein GltC