Oprl1 opioid related nociceptin receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Oprl1provided by RGD
Official Full Name: opioid related nociceptin receptor 1provided by RGD
Primary source: RGD:68438
See related: EnsemblRapid:ENSRNOG00000016768 AllianceGenome:RGD:68438
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: KOR3; OFQR; ORL1; Oprl; XOR1; KOR-3; LC132; MOR-C
Summary: The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Expression: Restricted expression toward (RPKM 104.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q43

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (189209495..189225406)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (168831934..168839920)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (177223779..177231663)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and Nociceptin Opioid Peptide Receptor Expression within 24 Hours.
Title: Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and Nociceptin Opioid Peptide Receptor Expression within 24 Hours.
NOP receptor antagonism attenuates reinstatement of alcohol-seeking through modulation of the mesolimbic circuitry in male and female alcohol-preferring rats.
Title: NOP receptor antagonism attenuates reinstatement of alcohol-seeking through modulation of the mesolimbic circuitry in male and female alcohol-preferring rats.
In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens.
Title: Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents.
The present in vitro and in vivo findings show that nociceptin/orphanin FQ receptor plays a crucial conserved role regulating the levels of the glutamate/aspartate transporter GLAST/EAAT1 in both human and rodent brain astrocytes.
Title: Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes.
Genetic deletion of NOP receptors confers resilience to drug abuse and support a role for NOP receptor antagonism as a potential treatment option for drug addiction.
Title: Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction.
Nociceptin/orphanin FQ mRNA is increased in the striatum from stressed, social defeat animal models.
Title: Social defeat disrupts reward learning and potentiates striatal nociceptin/orphanin FQ mRNA in rats.
Findings suggest that the Galphai1/Gbeta2(beta4)/Ggamma7 heterotrimeric G protein complex determines the nociceptin/orphanin FQ peptide receptor-mediated modulation of voltage-gated Ca(2+) channels channels in stellate ganglion neurons.
Title: Gγ7 proteins contribute to coupling of nociceptin/orphanin FQ peptide (NOP) opioid receptors and voltage-gated Ca(2+) channels in rat stellate ganglion neurons.
The opioid-like hepta-decapeptide nociceptin/orphanin FQ and its receptor nociceptin are widely distributed in the central nervous system where they are involved in a variety of biological functions including feeding, reward and emotional processes.
Title: Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption.
This study demonstrated the expression of the NOP receptor in human peripheral nerve and visceral tissues, with a marked increase of NOP-positive nerve fibres in urinary bladder syndromes.
Title: Nociceptin/orphanin FQ receptor expression in clinical pain disorders and functional effects in cultured neurons.
Study shows an influence of the prelimbic nociceptin/orphanin FQ neurotransmission, but not the infralimbic nociceptin receptors, in the control of cardiovascular responses observed during acute stress, by increasing cardiac parasympathetic activity.
Title: NOP receptors in the prelimbic cortex have an inhibitory influence on cardiovascular responses induced by restraint stress.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140403 (e-PCR)
- UniSTS:222478

D3Hmgc22 (e-PCR)
- UniSTS:526192

Oprl1 (e-PCR), detects polymorphism
- UniSTS:499104

Oprl (e-PCR), detects polymorphism
- UniSTS:144088

RH139571 (e-PCR)
- UniSTS:221656

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables nociceptin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nociceptin receptor activity	IEA Inferred from Electronic Annotation more info
enables nociceptin receptor activity	ISO Inferred from Sequence Orthology more info
enables nociceptin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_positive_effect calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in conditioned place preference	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cAMP/PKA signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron-neuron synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of urine volume	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nociceptin receptor

Names: ROR-C; kappa-type 3 opioid receptor; nociceptin receptor ORL1; opiate receptor-like 1; opioid receptor-like 1; orphanin FQ receptor; orphanin FQ receptor-a; orphanin FQ receptor-b; orphanin FQ receptor-e; peptide receptor; seven transmembrane G protein-coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001318947.1 → NP_001305876.1 nociceptin receptor isoform 1x

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

Q9JIN4

Conserved Domains (2) summary

pfam00001
Location:65 → 316

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:63 → 185

7tm_4; Olfactory receptor
NM_001318948.1 → NP_001305877.1 nociceptin receptor isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an additional internal exon, which results in translation initiation from an alternate start codon compared to variant 1. The encoded isoform (2) is shorter with a distinct N-terminus compared to isoform 1.

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6KLW8, F7FLX3, Q8CH83

Related

ENSRNOP00000030087.5, ENSRNOT00000031328.8

Conserved Domains (2) summary

cd14964
Location:69 → 95

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:61 → 313

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_031569.4 → NP_113757.1 nociceptin receptor isoform 1

See identical proteins and their annotated locations for NP_113757.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1).

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P35370, Q791R4

UniProtKB/TrEMBL

A6KLW2, Q9JIN4

Conserved Domains (1) summary

cd15092
Location:49 → 327

7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

189209495..189225406

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104432.2 → XP_038960360.1 nociceptin receptor isoform X2

UniProtKB/TrEMBL

A6KLW8, F7FLX3, Q8CH83

Conserved Domains (2) summary

cd14964
Location:69 → 95

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:61 → 313

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006235739.5 → XP_006235801.1 nociceptin receptor isoform X2

See identical proteins and their annotated locations for XP_006235801.1

UniProtKB/TrEMBL

A6KLW8, F7FLX3, Q8CH83

Conserved Domains (2) summary

cd14964
Location:69 → 95

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:61 → 313

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006235738.5 → XP_006235800.1 nociceptin receptor isoform X1

See identical proteins and their annotated locations for XP_006235800.1

UniProtKB/Swiss-Prot

P35370, Q791R4

UniProtKB/TrEMBL

A6KLW2, Q9JIN4

Conserved Domains (1) summary

cd15092
Location:49 → 327

7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_039104433.2 → XP_038960361.1 nociceptin receptor isoform X3

UniProtKB/TrEMBL

A6KLW9, Q8CH83

Conserved Domains (2) summary

cd14964
Location:5 → 31

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:1 → 249

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039104431.2 → XP_038960359.1 nociceptin receptor isoform X1

UniProtKB/Swiss-Prot

P35370, Q791R4

UniProtKB/TrEMBL

A6KLW2, Q9JIN4

Conserved Domains (1) summary

cd15092
Location:49 → 327

7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017591516.3 → XP_017447005.1 nociceptin receptor isoform X3

UniProtKB/TrEMBL

A6KLW9, Q8CH83

Conserved Domains (2) summary

cd14964
Location:5 → 31

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:1 → 249

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily