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Itgb1 integrin subunit beta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24511, updated on 27-Nov-2024

Summary

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Symbol: Itgb1provided by RGD
Full Name: integrin subunit beta 1provided by RGD
Primary source: RGD:2927
See related: EnsemblRapid:ENSRNOG00000010966 AllianceGenome:RGD:2927
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including cytoskeletal protein binding activity; enzyme binding activity; and fibronectin binding activity. Involved in several processes, including bicellular tight junction assembly; regulation of cell projection organization; and regulation of neuron differentiation. Located in several cellular components, including acrosomal vesicle; focal adhesion; and hemidesmosome. Part of integrin alpha3-beta1 complex and integrin alpha9-beta1 complex. Is active in glutamatergic synapse; glycinergic synapse; and postsynaptic membrane. Used to study hydrocephalus and myocardial infarction. Biomarker of glomerulonephritis. Orthologous to human ITGB1 (integrin subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 1593.5), Heart (RPKM 1215.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Itgb1 in Genome Data Viewer

Location:: 19q12

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (73602277..73650271)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (56705123..56753199)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (61677512..61725537)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kcnh2 deletion is associated with rat embryonic development defects via destruction of KCNH2-integrin beta1 complex.
Title: Kcnh2 deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex.
Synergistic regulation of microglia differentiation by CD93 and integrin beta1 in the rat pneumococcal meningitis model.
Title: Synergistic regulation of microglia differentiation by CD93 and integrin β1 in the rat pneumococcal meningitis model.
ITGB1 Suppresses Autophagy Through Inhibiting The mTORC2/AKT Signaling Pathway In H9C2 Cells.
Title: ITGB1 Suppresses Autophagy Through Inhibiting The mTORC2/AKT Signaling Pathway In H9C2 Cells.
Delayed notochordal cell disappearance through integrin alpha5beta1 mechanotransduction during ex-vivo dynamic loading-induced intervertebral disc degeneration.
Title: Delayed notochordal cell disappearance through integrin α5β1 mechanotransduction during ex-vivo dynamic loading-induced intervertebral disc degeneration.
Inhibited effect of an RGD peptide hydrogel on the expression of beta1-integrin, FAK, and Akt in Tenon's capsule fibroblasts.
Title: Inhibited effect of an RGD peptide hydrogel on the expression of β1-integrin, FAK, and Akt in Tenon's capsule fibroblasts.
ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling.
Title: ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling.
Integrin-dependent microgliosis mediates ketamine-induced neuronal apoptosis during postnatal rat retinal development.
Title: Integrin-dependent microgliosis mediates ketamine-induced neuronal apoptosis during postnatal rat retinal development.
DDR2 acted via integrin-beta1 to regulate alpha-smooth muscle actin (alpha-SMA) and collagen type I expression in Ang II-exposed cardiac fibroblasts.
Title: Collagen receptor cross-talk determines α-smooth muscle actin-dependent collagen gene expression in angiotensin II-stimulated cardiac fibroblasts.
pUR4 reduces TNF-alpha-induced beta1 integrin activation by depleting ECM FN, leading to a decrease in endothelial hyperpermeability and maintenance of monolayer integrity.
Title: Fibronectin inhibitor pUR4 attenuates tumor necrosis factor α-induced endothelial hyperpermeability by modulating β1 integrin activation.
Biotin labeling of cell surface proteins from cardiomyocytes overexpressing ADAP1 revealed that it reduces the surface expression of b1-integrin, an effect that is strongly potentiated by Mek1ca overexpression.
Title: ADAP1 limits neonatal cardiomyocyte hypertrophy by reducing integrin cell surface expression.

Submit: New GeneRIF Correction See all GeneRIFs (113)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itgb1 (e-PCR), detects polymorphism
- UniSTS:226053

Itgb1 (e-PCR), detects polymorphism
- UniSTS:143627

Itgb1 (e-PCR), detects polymorphism
- UniSTS:143628

Itgb1 (e-PCR), detects polymorphism
- UniSTS:143629

RH138141 (e-PCR)
- UniSTS:220228

AU048052 (e-PCR)
- UniSTS:109920

UniSTS:256618 (e-PCR)
- UniSTS:256618

Itgb1 (e-PCR), detects polymorphism
- UniSTS:256618

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to C-X3-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to C-X3-C chemokine binding	ISO Inferred from Sequence Orthology more info
contributes_to C-X3-C chemokine binding	ISS Inferred from Sequence or Structural Similarity more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	ISO Inferred from Sequence Orthology more info
enables alpha-actinin binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables collagen binding involved in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding involved in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibronectin binding	IDA Inferred from Direct Assay more info	PubMed
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding involved in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
enables integrin binding involved in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
enables integrin binding involved in cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to laminin binding	IBA Inferred from Biological aspect of Ancestor more info
enables laminin binding	IDA Inferred from Direct Assay more info	PubMed
enables laminin binding	IEA Inferred from Electronic Annotation more info
enables laminin binding	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to laminin binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in CD40 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in axon extension	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon extension	ISO Inferred from Sequence Orthology more info
involved_in basement membrane organization	IEA Inferred from Electronic Annotation more info
involved_in basement membrane organization	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium-independent cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cardiac cell fate specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac cell fate specification	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell myoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle cell myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionizing radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to low-density lipoprotein particle stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in establishment of Sertoli cell barrier	IEP Inferred from Expression Pattern more info	PubMed
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in formation of radial glial scaffolds	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within formation of radial glial scaffolds	ISO Inferred from Sequence Orthology more info
involved_in germ cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within germ cell migration	ISO Inferred from Sequence Orthology more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in maintenance of postsynaptic specialization structure	EXP Inferred from Experiment more info	PubMed
involved_in maintenance of postsynaptic specialization structure	IDA Inferred from Direct Assay more info	PubMed
involved_in maternal process involved in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in mesodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in myoblast fate specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myoblast fate specification	ISO Inferred from Sequence Orthology more info
involved_in myoblast fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vasoconstriction	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate uptake involved in transmission of nerve impulse	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of glutamate uptake involved in transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in protein transport within lipid bilayer	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reactive gliosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_negative_effect reactive gliosis	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of collagen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of collagen catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of spontaneous synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_negative_effect regulation of spontaneous synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse pruning	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse pruning	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEA Inferred from Electronic Annotation more info
involved_in response to muscle activity	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to transforming growth factor beta	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sarcomere organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sarcomere organization	ISO Inferred from Sequence Orthology more info
NOT involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in synaptic membrane adhesion to extracellular matrix	IC Inferred by Curator more info
involved_in tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in visual learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cerebellar climbing fiber to Purkinje cell synapse	IEA Inferred from Electronic Annotation more info
is_active_in cerebellar climbing fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in glial cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in glycinergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glycinergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in hemidesmosome	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha1-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha10-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha11-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha2-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha3-beta1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha3-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha4-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha5-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha6-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha7-beta1 complex	IEA Inferred from Electronic Annotation more info
part_of integrin alpha7-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha9-beta1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha9-beta1 complex	IEA Inferred from Electronic Annotation more info
part_of integrin alpha9-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alphav-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	IEA Inferred from Electronic Annotation more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in myelin sheath abaxonal region	IEA Inferred from Electronic Annotation more info
located_in myelin sheath abaxonal region	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin beta-1

Names: VLA-4 subunit beta; beta OL; beta oligodendroglia; collagen alpha-1(I) chain-like; fibronectin receptor subunit beta; integrin VLA-4 subunit beta; integrin beta 1 (fibronectin receptor beta)

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017022.2 → NP_058718.2 integrin beta-1 precursor

See identical proteins and their annotated locations for NP_058718.2

Status: VALIDATED

Source sequence(s)

BC131845

UniProtKB/Swiss-Prot

A2RRT8, P49134

UniProtKB/TrEMBL

A6KJ65

Related

ENSRNOP00000093150.2, ENSRNOT00000109602.2

Conserved Domains (5) summary

smart00187
Location:34 → 464

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:640 → 727

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:755 → 795

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:466 → 495

I-EGF_1; Integrin beta epidermal growth factor like domain 1

NF033759
Location:460 → 650

exchanger_TraA; outer membrane exchange protein TraA