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    Fbxo22 F-box protein 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300724, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fbxo22provided by RGD
    Official Full Name
    F-box protein 22provided by RGD
    Primary source
    RGD:1306664
    See related
    EnsemblRapid:ENSRNOG00000022702 AllianceGenome:RGD:1306664
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of skeletal muscle fiber development. Predicted to act upstream of or within several processes, including nucleocytoplasmic transport; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of myotube differentiation. Predicted to be located in cytoplasm and nucleus. Orthologous to human FBXO22 (F-box protein 22). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 293.3), Thymus (RPKM 193.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxo22 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (64476034..64492063)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (55579906..55595981)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (59770032..59786061)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094166 Neighboring gene cholinergic receptor nicotinic beta 4 subunit Neighboring gene ubiquitin conjugating enzyme E2 Q2 Neighboring gene neuregulin 4 Neighboring gene uncharacterized LOC134480177 Neighboring gene uncharacterized LOC134480176

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine. Dikopoltsev E, et al. J Biol Chem, 2014 Dec 5. PMID 25336657, Free PMC Article
    2. Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo. Lagirand-Cantaloube J, et al. PLoS One, 2009. PMID 19319192, Free PMC Article
    3. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124731

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of skeletal muscle fiber development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037770.1 → NP_001032859.1  F-box only protein 22

      See identical proteins and their annotated locations for NP_001032859.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107670
      UniProtKB/TrEMBL
      Q32Q88
      Related
      ENSRNOP00000020309.7, ENSRNOT00000020309.8
      Conserved Domains (2) summary
      COG4398
      Location:292 → 394
      FIST; Small ligand-binding sensory domain FIST [Signal transduction mechanisms]
      pfam12937
      Location:24 → 54
      F-box-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      64476034..64492063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081080.2 → XP_038937008.1  F-box only protein 22 isoform X2

      UniProtKB/TrEMBL
      A6J4P3, F7EM85
      Conserved Domains (1) summary
      COG4398
      Location:192 → 294
      FIST; Small ligand-binding sensory domain FIST [Signal transduction mechanisms]

    2. XM_039081077.2 → XP_038937005.1  F-box only protein 22 isoform X1

      Conserved Domains (2) summary
      COG4398
      Location:237 → 339
      FIST; Small ligand-binding sensory domain FIST [Signal transduction mechanisms]
      pfam12937
      Location:24 → 54
      F-box-like

    3. XM_039081081.2 → XP_038937009.1  F-box only protein 22 isoform X2

      UniProtKB/TrEMBL
      A6J4P3, F7EM85
      Related
      ENSRNOP00000110506.1, ENSRNOT00000132494.1
      Conserved Domains (1) summary
      COG4398
      Location:192 → 294
      FIST; Small ligand-binding sensory domain FIST [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version

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