Hipk3 homeodomain interacting protein kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hipk3provided by RGD
Official Full Name: homeodomain interacting protein kinase 3provided by RGD
Primary source: RGD:619884
See related: EnsemblRapid:ENSRNOG00000011358 AllianceGenome:RGD:619884
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ANPK
Summary: Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in several processes, including mRNA transcription; negative regulation of JUN kinase activity; and protein phosphorylation. Predicted to be located in cytosol; nuclear body; and plasma membrane. Predicted to be active in PML body and cytoplasm. Orthologous to human HIPK3 (homeodomain interacting protein kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 646.6), Muscle (RPKM 605.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q32

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (111251863..111322815, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (90796980..90866701, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (94349778..94419185, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression.
Title: MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression.
Overexpression of miR-431 inhibits cardiomyocyte apoptosis following myocardial infarction via targeting HIPK3.
Title: Overexpression of miR-431 inhibits cardiomyocyte apoptosis following myocardial infarction via targeting HIPK3.
HIPK3 Mediates Inflammatory Cytokines and Oxidative Stress Markers in Monocytes in a Rat Model of Sepsis Through the JNK/c-Jun Signaling Pathway.
Title: HIPK3 Mediates Inflammatory Cytokines and Oxidative Stress Markers in Monocytes in a Rat Model of Sepsis Through the JNK/c-Jun Signaling Pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

D3Rat263 (e-PCR), detects polymorphism
- UniSTS:227648

HIPK3__6530 (e-PCR)
- UniSTS:463980

AU025901 (e-PCR)
- UniSTS:114809

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in PML body	IBA Inferred from Biological aspect of Ancestor more info
located_in PML body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: homeodomain-interacting protein kinase 3

Names: androgen receptor-interacting nuclear protein kinase; nuclear serine/threonine protein kinase

NP_001382009.1

EC 2.7.11.1

NP_113975.2

EC 2.7.11.1

XP_008760294.2

EC 2.7.11.1

XP_063140716.1

EC 2.7.11.1

XP_063140717.1

EC 2.7.11.1

XP_063140718.1

EC 2.7.11.1

XP_063140719.1

EC 2.7.11.1

XP_063140720.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395080.1 → NP_001382009.1 homeodomain-interacting protein kinase 3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

O88850

UniProtKB/TrEMBL

Q498U5

Related

ENSRNOP00000015775.3, ENSRNOT00000015775.5

Conserved Domains (1) summary

cd14229
Location:196 → 525

STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3
NM_031787.2 → NP_113975.2 homeodomain-interacting protein kinase 3 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

O88850

UniProtKB/TrEMBL

A6HNU0, F7EY07

Conserved Domains (1) summary

cd14229
Location:196 → 525

STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

111251863..111322815 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008762072.4 → XP_008760294.2 homeodomain-interacting protein kinase 3 isoform X6

UniProtKB/TrEMBL

A0A0G2K4W6
XM_063284647.1 → XP_063140717.1 homeodomain-interacting protein kinase 3 isoform X2

UniProtKB/Swiss-Prot

O88850
XM_063284646.1 → XP_063140716.1 homeodomain-interacting protein kinase 3 isoform X1

UniProtKB/Swiss-Prot

O88850

UniProtKB/TrEMBL

A0A8I6GE65

Related

ENSRNOP00000085704.1, ENSRNOT00000105868.2
XM_063284650.1 → XP_063140720.1 homeodomain-interacting protein kinase 3 isoform X5
XM_063284649.1 → XP_063140719.1 homeodomain-interacting protein kinase 3 isoform X4
XM_063284648.1 → XP_063140718.1 homeodomain-interacting protein kinase 3 isoform X3