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    Dnah9 dynein, axonemal, heavy chain 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117251, updated on 27-Nov-2024

    Summary

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    Symbol
    Dnah9provided by RGD
    Full Name
    dynein, axonemal, heavy chain 9provided by RGD
    Primary source
    RGD:621799
    See related
    EnsemblRapid:ENSRNOG00000004171 AllianceGenome:RGD:621799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to act upstream of or within cerebrospinal fluid circulation; establishment of localization in cell; and mucociliary clearance. Predicted to be located in distal portion of axoneme; extracellular region; and motile cilium. Predicted to be part of outer dynein arm. Predicted to be active in 9+2 motile cilium and axoneme. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 40. Orthologous to human DNAH9 (dynein axonemal heavy chain 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 59.4), Brain (RPKM 23.4) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnah9 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    72
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (50996796..51363977, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (50496174..50864909, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (52351226..52711289, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene THAP domain-containing protein 5-like Neighboring gene mitogen activated protein kinase kinase 4 Neighboring gene zinc finger protein 18 Neighboring gene uncharacterized LOC120095122 Neighboring gene shisa family member 6 Neighboring gene uncharacterized LOC134480810 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus. Fassad MR, et al. Am J Hum Genet, 2018 Dec 6. PMID 30471717, Free PMC Article
    2. Axonemal dynein expression in human fetal tracheal epithelium. Carson JL, et al. Am J Physiol Lung Cell Mol Physiol, 2002 Mar. PMID 11839535
    3. Characterization of an axonemal dynein heavy chain expressed early in airway epithelial ciliogenesis. Reed W, et al. Am J Respir Cell Mol Biol, 2000 Dec. PMID 11104725
    4. CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components. Ide T, et al. PLoS Genet, 2020 Dec. PMID 33347437, Free PMC Article
    5. Mislocalization of DNAH5 and DNAH9 in respiratory cells from patients with primary ciliary dyskinesia. Fliegauf M, et al. Am J Respir Crit Care Med, 2005 Jun 15. PMID 15750039, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cerebrospinal fluid circulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mucociliary clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in 9+2 motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in distal portion of axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of outer dynein arm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal heavy chain 9
    Names
    dynein heavy chain 9, axonemal
    dynein, axonemal, heavy polypeptide 9
    mCG140381-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427097.1 → NP_001414026.1  dynein axonemal heavy chain 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      Related
      ENSRNOP00000005583.9, ENSRNOT00000005583.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      50996796..51363977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087294.2 → XP_038943222.1  dynein axonemal heavy chain 9 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A869
      Conserved Domains (6) summary
      COG5245
      Location:1422 → 4053
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:2970 → 3313
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:212 → 692
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1195 → 1601
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1735 → 2061
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4092 → 4387
      Dynein_C; Dynein heavy chain C-terminal domain

    2. XM_039087292.2 → XP_038943220.1  dynein axonemal heavy chain 9 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A869
      Conserved Domains (6) summary
      COG5245
      Location:1517 → 4097
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:3014 → 3357
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:212 → 787
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1290 → 1645
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1779 → 2105
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4136 → 4431
      Dynein_C; Dynein heavy chain C-terminal domain

    3. XM_039087293.2 → XP_038943221.1  dynein axonemal heavy chain 9 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A869
      Conserved Domains (6) summary
      COG5245
      Location:1517 → 4072
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:3065 → 3408
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:212 → 787
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1290 → 1696
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1830 → 2156
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4111 → 4406
      Dynein_C; Dynein heavy chain C-terminal domain

    4. XM_039087295.2 → XP_038943223.1  dynein axonemal heavy chain 9 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A869
      Conserved Domains (6) summary
      COG5245
      Location:1194 → 3825
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:2742 → 3085
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:2 → 464
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:967 → 1373
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1507 → 1833
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:3864 → 4159
      Dynein_C; Dynein heavy chain C-terminal domain

    5. XM_039087300.2 → XP_038943228.1  dynein axonemal heavy chain 9 isoform X10

      Conserved Domains (4) summary
      COG5245
      Location:87 → 2405
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:1322 → 1665
      MT; Microtubule-binding stalk of dynein motor
      pfam12774
      Location:87 → 413
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:2444 → 2739
      Dynein_C; Dynein heavy chain C-terminal domain

    6. XM_039087302.2 → XP_038943230.1  dynein axonemal heavy chain 9 isoform X12

      Conserved Domains (9) summary
      pfam12777
      Location:739 → 1082
      MT; Microtubule-binding stalk of dynein motor
      pfam17857
      Location:323 → 422
      AAA_lid_1; AAA+ lid domain
      pfam03028
      Location:1567 → 1687
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam12775
      Location:111 → 290
      AAA_7; P-loop containing dynein motor region D3
      pfam12780
      Location:467 → 726
      AAA_8; P-loop containing dynein motor region D4
      pfam12781
      Location:1109 → 1323
      AAA_9; ATP-binding dynein motor region D5
      pfam17852
      Location:5 → 104
      Dynein_AAA_lid; Dynein heavy chain AAA lid domain
      pfam18198
      Location:1701 → 1855
      AAA_lid_11; Dynein heavy chain AAA lid domain
      pfam18199
      Location:1861 → 2156
      Dynein_C; Dynein heavy chain C-terminal domain

    7. XM_039087303.2 → XP_038943231.1  dynein axonemal heavy chain 9 isoform X13

      Conserved Domains (9) summary
      pfam12777
      Location:724 → 1067
      MT; Microtubule-binding stalk of dynein motor
      pfam17857
      Location:308 → 407
      AAA_lid_1; AAA+ lid domain
      pfam03028
      Location:1552 → 1672
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam12775
      Location:96 → 275
      AAA_7; P-loop containing dynein motor region D3
      pfam12780
      Location:452 → 711
      AAA_8; P-loop containing dynein motor region D4
      pfam12781
      Location:1094 → 1308
      AAA_9; ATP-binding dynein motor region D5
      pfam17852
      Location:1 → 89
      Dynein_AAA_lid; Dynein heavy chain AAA lid domain
      pfam18198
      Location:1686 → 1840
      AAA_lid_11; Dynein heavy chain AAA lid domain
      pfam18199
      Location:1846 → 2141
      Dynein_C; Dynein heavy chain C-terminal domain

    8. XM_017597645.3 → XP_017453134.1  dynein axonemal heavy chain 9 isoform X5

      UniProtKB/TrEMBL
      F1LV07

    9. XM_039087296.2 → XP_038943224.1  dynein axonemal heavy chain 9 isoform X6

      UniProtKB/TrEMBL
      F1LV07
      Conserved Domains (7) summary
      COG5245
      Location:1517 → 3710
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:3065 → 3408
      MT; Microtubule-binding stalk of dynein motor
      pfam03028
      Location:3893 → 4013
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:212 → 787
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1290 → 1696
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1830 → 2156
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2793 → 3052
      AAA_8; P-loop containing dynein motor region D4

    10. XM_039087297.2 → XP_038943225.1  dynein axonemal heavy chain 9 isoform X7

      UniProtKB/TrEMBL
      F1LV07
      Conserved Domains (7) summary
      COG5245
      Location:1517 → 3710
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:3065 → 3408
      MT; Microtubule-binding stalk of dynein motor
      pfam03028
      Location:3893 → 3913
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:212 → 787
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1290 → 1696
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1830 → 2156
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2793 → 3052
      AAA_8; P-loop containing dynein motor region D4

    11. XM_039087298.2 → XP_038943226.1  dynein axonemal heavy chain 9 isoform X8

      UniProtKB/TrEMBL
      F1LV07
      Conserved Domains (6) summary
      COG5245
      Location:1517 → 3710
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:3065 → 3408
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:212 → 787
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1290 → 1696
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1830 → 2156
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2793 → 3052
      AAA_8; P-loop containing dynein motor region D4

    12. XM_063268325.1 → XP_063124395.1  dynein axonemal heavy chain 9 isoform X9

    13. XM_039087301.2 → XP_038943229.1  dynein axonemal heavy chain 9 isoform X11

      UniProtKB/TrEMBL
      A6HFG1
      Conserved Domains (4) summary
      pfam08385
      Location:212 → 787
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1290 → 1696
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1830 → 2156
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      cl38936
      Location:2144 → 2279
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_005490291.2 RNA Sequence

    2. XR_005490292.2 RNA Sequence

    3. XR_005490293.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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