Adora3 adenosine A3 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Adora3provided by RGD
Full Name: adenosine A3 receptorprovided by RGD
Primary source: RGD:2051
See related: EnsemblRapid:ENSRNOG00000015788 AllianceGenome:RGD:2051
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: A3; TGPCR1
Summary: Enables G protein-coupled adenosine receptor activity. Involved in G protein-coupled receptor signaling pathway; presynaptic modulation of chemical synaptic transmission; and regulation of norepinephrine secretion. Located in presynaptic membrane. Is active in Schaffer collateral - CA1 synapse. Orthologous to human ADORA3 (adenosine A3 receptor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (196077042..196080686)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (193352759..193392946)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (208492231..208536910)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of adenosine A3 receptor attenuates progression of osteoarthritis through inhibiting the NLRP3/caspase-1/GSDMD induced signalling.
Title: Activation of adenosine A3 receptor attenuates progression of osteoarthritis through inhibiting the NLRP3/caspase-1/GSDMD induced signalling.
Activation of adenosine A3 receptor protects retinal ganglion cells from degeneration induced by ocular hypertension.
Title: Activation of adenosine A(3) receptor protects retinal ganglion cells from degeneration induced by ocular hypertension.
Adenosine A(3) receptor activation protects the myocardium from reperfusion/reoxygenation injury.
Title: Adenosine A(3) receptor activation protects the myocardium from reperfusion/reoxygenation injury.
Inosine-adenosine couple through activation of hepatic A(3) AdoR is the main signal for releasing glucose from liver glycogen and for promoting hyperglycemia following experimental injury of I-R from lower limbs.
Title: Evidence that endogenous inosine and adenosine-mediated hyperglycaemia during ischaemia-reperfusion through A3 adenosine receptors.
adenosine may trigger oligodendrocyte death via activation of A3 receptors
Title: A3 Adenosine receptors mediate oligodendrocyte death and ischemic damage to optic nerve.
Activation of A3R may have great potential in the management of retinal neurodegenerative diseases.
Title: Adenosine A3 receptor activation is neuroprotective against retinal neurodegeneration.
A1R and A3R, were identified to be involved in the adenosine-induced Ca(2+) release from intracellular stores in neurons.
Title: Evidence for A1 and A 3 receptors mediating adenosine-induced intracellular calcium release in the dorsal root ganglion neurons by using confocal microscopy imaging.
[review] Activation of both Adora1 and Adora3 receptors prior to ischemia has been shown in multiple experimental models to reduce ischemia/reperfusion-induced cardiac injury.
Title: Adenosine receptor-mediated cardioprotection: are all 4 subtypes required or redundant?
Adenosine A3 receptors are present in rat hippocampal nerve terminal membranes; this indicates that A3 receptors are present in CNS neurons in the hippocampus.
Title: Adenosine A3 receptors are located in neurons of the rat hippocampus.
Oxygen/glucose deprivation induces a reduction in synaptic AMPA receptors mediated by adenosine A3 and mGluR1 receptors.
Title: Oxygen/glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors.

Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

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Markers

RH94668 (e-PCR)
- UniSTS:119915

ADORA3 (e-PCR)
- UniSTS:266362

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled adenosine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled adenosine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled adenosine receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within histamine secretion by mast cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of mast cell degranulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mucus secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of norepinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenosine receptor A3

Names: adenosine receptor A3-like; putative G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302750.1 → NP_001289679.1 adenosine receptor A3 isoform a

See identical proteins and their annotated locations for NP_001289679.1

Status: VALIDATED

Description

Transcript Variant: This variant (A3i) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

Q4PKD9

Related

ENSRNOP00000021236.3, ENSRNOT00000021236.5

Conserved Domains (2) summary

pfam00001
Location:31 → 301

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:23 → 126

7tm_4; Olfactory receptor
NM_001302751.1 → NP_001289680.1 adenosine receptor A3 isoform b

See identical proteins and their annotated locations for NP_001289680.1

Status: VALIDATED

Description

Transcript Variant: This variant (A3) uses an alternate in-frame splice site in the 3' terminal exon, compared to variant A3i, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P28647, Q63792

UniProtKB/TrEMBL

A6HUN6, Q4PKD9

Conserved Domains (2) summary

pfam00001
Location:31 → 284

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:23 → 176

7tm_4; Olfactory receptor