Nos1ap nitric oxide synthase 1 adaptor protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nos1approvided by RGD
Official Full Name: nitric oxide synthase 1 adaptor proteinprovided by RGD
Primary source: RGD:620106
See related: AllianceGenome:RGD:620106
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Capon
Summary: Enables PDZ domain binding activity; enzyme binding activity; and signaling adaptor activity. Involved in neuron projection regeneration; positive regulation of peptidyl-cysteine S-nitrosylation; and regulation of calcium ion transmembrane transport. Located in cytosol and nuclear membrane. Is active in glutamatergic synapse; postsynapse; and presynapse. Used to study depressive disorder. Biomarker of congestive heart failure and sciatic neuropathy. Human ortholog(s) of this gene implicated in nephrotic syndrome type 22. Orthologous to human NOS1AP (nitric oxide synthase 1 adaptor protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 51.8), Spleen (RPKM 36.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (85080558..85353741, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (82547799..82820999, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (88653123..88943976, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NOS1AP Interacts with alpha-Synuclein and Aggregates in Yeast and Mammalian Cells.
Title: NOS1AP Interacts with α-Synuclein and Aggregates in Yeast and Mammalian Cells.
This study showed that critical role for the schizophrenia-associated gene NOS1AP in cortical patterning and neuron migration.
Title: Nitric oxide synthase 1 adaptor protein, a protein implicated in schizophrenia, controls radial migration of cortical neurons.
CAPON modulates neuronal calcium during dysautonomia in hypertension.
Title: CAPON modulates neuronal calcium handling and cardiac sympathetic neurotransmission during dysautonomia in hypertension.
nNOS and CAPON co-localize in the pre-sympathetic autonomic neurons in the paraventricular nucleus and their expression is reciprocally regulated in congestive heart failure via angiotensin II.
Title: Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: role for CAPON and Ang II.
CAPON might play a proactive role in the process of inflammation by transferring from cytoplasm to the nucleus and through the NMDA-nNOS signal pathway
Title: The nuclear localization of CAPON in hippocampus and cerebral cortex neurons after lipopolysaccharide stimulation.
NOS1AP plays an important role in the mammalian synapse.
Title: NOS1AP associates with Scribble and regulates dendritic spine development.
Data show that mRNA and protein for CAPON increased at 2 h after spinal cord injury and peaked at 8 h, gradually recovered to the baseline level at 14 days, and expression of nNOS mRNA and protein was similar to that of CAPON.
Title: Expression of CAPON after spinal cord injury in rats.
CAPON may be involved in various pathological conditions including nerve regeneration, neuron loss or survival and even pain process via regulating the nNOS activity or through the downstream targets of Dexras1.
Title: Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection.
These data suggest that CAPON and all these three isoforms of NOS might be involved in muscle regeneration after nerve injury.
Title: Involvement of CAPON and nitric oxide synthases in rat muscle regeneration after peripheral nerve injury.

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General gene information

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Markers

RH142695 (e-PCR)
- UniSTS:231942

BF393830 (e-PCR)
- UniSTS:244271

D13Got59 (e-PCR)
- UniSTS:113481

BF399011 (e-PCR)
- UniSTS:247497

RH138049 (e-PCR)
- UniSTS:220136

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IDA Inferred from Direct Assay more info	PubMed
enables mitogen-activated protein kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nitric-oxide synthase binding	IBA Inferred from Biological aspect of Ancestor more info
enables nitric-oxide synthase binding	IDA Inferred from Direct Assay more info	PubMed
enables nitric-oxide synthase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nitric-oxide synthase binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in neuron projection regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in neurotransmitter secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of peptidyl-cysteine S-nitrosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cardiac muscle cell action potential	IC Inferred by Curator more info	PubMed
involved_in regulation of heart rate by chemical signal	ISO Inferred from Sequence Orthology more info
involved_in regulation of high voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of nitric oxide biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in regulation of nitric-oxide synthase activity	TAS Traceable Author Statement more info	PubMed
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in podosome	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

Names: C-terminal PDZ domain ligand of neuronal nitric oxide synthase; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; nitric oxide synthase 1 (neuronal) adaptor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138922.3 → NP_620277.2 carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

O54960

Conserved Domains (1) summary

cd01270
Location:2 → 180

PTB_CAPON-like; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) Phosphotyrosine-binding (PTB) domain