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    Chkb choline kinase beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29367, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Chkbprovided by RGD
    Official Full Name
    choline kinase betaprovided by RGD
    Primary source
    RGD:61826
    See related
    EnsemblRapid:ENSRNOG00000011404 AllianceGenome:RGD:61826
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Chkl; Chetk
    Summary
    Enables choline kinase activity. Predicted to be involved in CDP-choline pathway and phosphatidylethanolamine biosynthetic process. Predicted to act upstream of or within muscle organ development and phosphatidylcholine biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to human CHKB (choline kinase beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 120.4), Thymus (RPKM 109.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chkb in Genome Data Viewer
    Location:
    7q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122380592..122385102, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120500960..120504359, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130404818..130408813, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene synaptonemal complex central element protein 3 Neighboring gene carnitine palmitoyltransferase 1B Neighboring gene uncharacterized LOC134479955 Neighboring gene uncharacterized LOC134479956 Neighboring gene mitogen-activated protein kinase 8 interacting protein 2 Neighboring gene arylsulfatase A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Complete purification of choline kinase from rat kidney and preparation of rabbit antibody against rat kidney choline kinase. Ishidate K, et al. J Biol Chem, 1984 Dec 10. PMID 6094572
    2. Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy. Mitsuhashi S, et al. Hum Mol Genet, 2011 Oct 1. PMID 21750112, Free PMC Article
    3. Complementary DNA sequence for a 42 kDa rat kidney choline/ethanolamine kinase. Aoyama C, et al. Biochim Biophys Acta, 1998 Feb 5. PMID 9487136
    4. A congenital muscular dystrophy with mitochondrial structural abnormalities caused by defective de novo phosphatidylcholine biosynthesis. Mitsuhashi S, et al. Am J Hum Genet, 2011 Jun 10. PMID 21665002, Free PMC Article
    5. Expression of brain-type creatine kinase and ubiquitous mitochondrial creatine kinase in the fetal rat brain: evidence for a nuclear energy shuttle. Chen L, et al. J Comp Neurol, 1995 Dec 18. PMID 8847407

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables choline kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables choline kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables choline kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ethanolamine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ethanolamine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within muscle organ development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    choline/ethanolamine kinase
    Names
    CK
    CKB
    CKEKB
    EK
    choline/ethanolamine kinase beta
    ethanolamine kinase
    NP_058873.1
    XP_006242243.2
    XP_038934502.1
    XP_038934504.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017177.1 → NP_058873.1  choline/ethanolamine kinase

      See identical proteins and their annotated locations for NP_058873.1

      Status: PROVISIONAL

      Source sequence(s)
      AB006607
      UniProtKB/Swiss-Prot
      O54783
      UniProtKB/TrEMBL
      A6K7M9
      Related
      ENSRNOP00000015374.1, ENSRNOT00000015374.4
      Conserved Domains (1) summary
      cd05156
      Location:73 → 385
      ChoK_euk; Euykaryotic Choline Kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      122380592..122385102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242181.5 → XP_006242243.2  choline/ethanolamine kinase isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:162 → 399
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039078574.2 → XP_038934502.1  choline/ethanolamine kinase isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:69 → 306
      PKc_like; Protein Kinases, catalytic domain

    3. XM_039078576.2 → XP_038934504.1  choline/ethanolamine kinase isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:24 → 261
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_010052945.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54783.3 GenPept UniProtKB/Swiss-Prot:O54783

    Gene LinkOut

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