Slfn4 schlafen 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slfn4provided by MGI
Official Full Name: schlafen 4provided by MGI
Primary source: MGI:MGI:1329010
See related: Ensembl:ENSMUSG00000000204 AllianceGenome:MGI:1329010
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: The protein encoded by this gene belongs to the Schlafen family. All members of this family contain a Schlafen box domain that lies near an AAA domain. This protein belongs to the group 2 subset of Schlafen proteins, which are defined by a molecular weight between 58 kDa and 68 kDa and by the presence of a SWADL domain that contains the sequence Ser-Trp-Ala-Asp-Leu. In malignant melanoma cells, gene expression is up-regulated in response to interferon alpha. In bone marrow-derived macrophages, expression of this gene is induced during activation by Toll-like receptor agonists and repressed during macrophage colony-stimulating factor-mediated differentiation. Myelopoiesis is disrupted by constitutive overexpression in myeloid-lineage cells. A pseudogene of this gene is found on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression: Biased expression in liver E18 (RPKM 11.4), colon adult (RPKM 3.3) and 3 other tissues See more
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Genomic context

Location:: 11 C; 11 50.3 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (83066001..83081042)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (83175172..83190216)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLFN4 marks a GLI1-dependent population of myeloid-derived suppressor cells that predict a shift in the gastric mucosa to a metaplastic phenotype
Title: Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia.
several mouse Slfn genes are up-regulated in response to IFN treatment of mouse melanoma and renal cell carcinoma cells, including Slfn1, Slfn2, Slfn4, Slfn5, and Slfn8.
Title: Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.
Slfn4 mRNA levels were up-regulated during macrophage activation but down-regulated during differentiation. Constitutive Slfn4 expression in the myeloid lineage in vivo perturbs myelopoiesis
Title: Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: schlafen 4

Names: Schlafen family member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302559.1 → NP_001289488.1 schlafen 4

See identical proteins and their annotated locations for NP_001289488.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK137689, AL669916, BM230056

Consensus CDS

CCDS25158.1

UniProtKB/TrEMBL

B2RWZ6, Q3UV10, Q3UV66

Related

ENSMUSP00000132595.2, ENSMUST00000167596.2

Conserved Domains (1) summary

PHA02782
Location:94 → 384

PHA02782; hypothetical protein; Provisional
NM_011410.3 → NP_035540.2 schlafen 4

See identical proteins and their annotated locations for NP_035540.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK137559, AK137689, AL669916, BM230056

Consensus CDS

CCDS25158.1

UniProtKB/TrEMBL

B2RWZ6, Q3UV10, Q3UV66

Related

ENSMUSP00000000208.6, ENSMUST00000000208.13

Conserved Domains (1) summary

PHA02782
Location:94 → 384

PHA02782; hypothetical protein; Provisional