Ctnnal1 catenin alpha-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctnnal1provided by RGD
Official Full Name: catenin alpha-like 1provided by RGD
Primary source: RGD:1311434
See related: EnsemblRapid:ENSRNOG00000010593 AllianceGenome:RGD:1311434
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Catnal1
Summary: Predicted to enable actin filament binding activity and cadherin binding activity. Predicted to be involved in Rho protein signal transduction. Predicted to be located in cytosol. Orthologous to human CTNNAL1 (catenin alpha like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 105.0), Uterus (RPKM 100.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (76309546..76375869, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (71514340..71569431, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (73561249..73621070, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132548 (e-PCR)
- UniSTS:215831

BQ211407 (e-PCR)
- UniSTS:260919

RH144545 (e-PCR)
- UniSTS:233790

RH131123 (e-PCR)
- UniSTS:214406

RH141410 (e-PCR)
- UniSTS:223405

BE121176 (e-PCR)
- UniSTS:248029

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-catulin

Names: catenin (cadherin associated protein), alpha-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106649.1 → NP_001100119.1 alpha-catulin

Status: PROVISIONAL

Source sequence(s)

CH474039

UniProtKB/TrEMBL

A0A8I6GEV6, A6KDR8, D4A739

Related

ENSRNOP00000014888.4, ENSRNOT00000014888.6

Conserved Domains (1) summary

pfam01044
Location:91 → 674

Vinculin; Vinculin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

76309546..76375869 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287306.1 → XP_063143376.1 alpha-catulin isoform X1
XM_006238177.5 → XP_006238239.1 alpha-catulin isoform X2

UniProtKB/TrEMBL

A0A8I5Y1A6, A0A8I6GEV6

Related

ENSRNOP00000077198.1, ENSRNOT00000106413.2

Conserved Domains (1) summary

pfam01044
Location:51 → 634

Vinculin; Vinculin family
XM_039109442.2 → XP_038965370.1 alpha-catulin isoform X3

Conserved Domains (1) summary

pfam01044
Location:4 → 498

Vinculin; Vinculin family
XM_039109443.1 → XP_038965371.1 alpha-catulin isoform X4

Conserved Domains (1) summary

pfam01044
Location:54 → 411

Vinculin; Vinculin family