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    Car5b carbonic anhydrase 5B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302669, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Car5bprovided by RGD
    Official Full Name
    carbonic anhydrase 5Bprovided by RGD
    Primary source
    RGD:1549783
    See related
    EnsemblRapid:ENSRNOG00000029330 AllianceGenome:RGD:1549783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ca5b
    Summary
    Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to act upstream of or within response to bacterium. Predicted to be active in mitochondrion. Orthologous to human CA5B (carbonic anhydrase 5B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 532.7), Lung (RPKM 95.4) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Car5b in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (34106553..34166651)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (30474697..30534797)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (32232106..32291124)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4, pseudogene 2 Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 Neighboring gene adaptor related protein complex 1 subunit sigma 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles. Shah GN, et al. Proc Natl Acad Sci U S A, 2000 Feb 15. PMID 10677517, Free PMC Article
    2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC93720

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbonate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbonate dehydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase 5B, mitochondrial
    Names
    CA-VB
    carbonate dehydratase VB
    carbonic anhydrase VB, mitochondrial
    NP_001005551.1
    XP_006256921.1
    XP_038955584.1
    XP_038955585.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005551.3 → NP_001005551.1  carbonic anhydrase 5B, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_001005551.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q66HG6
      UniProtKB/TrEMBL
      A0A8I5ZPN0, A6K2L9
      Conserved Domains (1) summary
      cl00012
      Location:61 → 296
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    2. NM_001434027.1 → NP_001420956.1  carbonic anhydrase 5B, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    3. NM_001434028.1 → NP_001420957.1  carbonic anhydrase 5B, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      34106553..34166651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256859.4 → XP_006256921.1  carbonic anhydrase 5B, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q66HG6
      UniProtKB/TrEMBL
      A0A8I5ZPN0, A6K2L9
      Conserved Domains (1) summary
      cl00012
      Location:61 → 296
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    2. XM_039099657.1 → XP_038955585.1  carbonic anhydrase 5B, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZPN0
      Conserved Domains (1) summary
      cl00012
      Location:61 → 264
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    3. XM_039099656.1 → XP_038955584.1  carbonic anhydrase 5B, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q66HG6
      UniProtKB/TrEMBL
      A0A8I5ZPN0, A6K2L9
      Related
      ENSRNOP00000043235.3, ENSRNOT00000047354.6
      Conserved Domains (1) summary
      cl00012
      Location:61 → 296
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HG6.1 GenPept UniProtKB/Swiss-Prot:Q66HG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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