Pak1 p21 (RAC1) activated kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pak1provided by RGD
Official Full Name: p21 (RAC1) activated kinase 1provided by RGD
Primary source: RGD:3250
See related: EnsemblRapid:ENSRNOG00000029784 AllianceGenome:RGD:3250
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including nervous system development; positive regulation of cell migration; and regulation of cell growth. Located in several cellular components, including Z disc; intercalated disc; and ruffle. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 564.9), Adrenal (RPKM 131.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (161522399..161637623)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (152111172..152226390)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (162768156..162883356)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats.
Title: Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats.
Up-regulation of P21-activated kinase 1 in osteoarthritis chondrocytes is responsible for osteoarthritic cartilage destruction.
Title: Up-regulation of P21-activated kinase 1 in osteoarthritis chondrocytes is responsible for osteoarthritic cartilage destruction.
MiRNA-221 regulates proliferation, apoptosis and insulin secretion in islet beta cells through targeting PAK1, thus protecting gestational diabetes mellitus -induced islet dysfunction in a rat model
Title: MiRNA-221 protects islet β cell function in gestational diabetes mellitus by targeting PAK1.
These results expand the model of insulin-stimulated glucose uptake in skeletal muscle cells by implicating p41ARC as a new component of the insulin-signaling cascade and connecting PAK1 signaling to N-WASP-cortactin-mediated actin polymerization and GLUT4 vesicle translocation.
Title: The actin-related p41ARC subunit contributes to p21-activated kinase-1 (PAK1)-mediated glucose uptake into skeletal muscle cells.
the oxidative stress-induced down-regulation of PAK1 activity could be involved in the loss of mesencephalic dopaminergic neurons.
Title: Down-regulation of p21-activated serine/threonine kinase 1 is involved in loss of mesencephalic dopamine neurons.
PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases.
Title: Protein kinase D1 (PKD1) phosphorylation on Ser(203) by type I p21-activated kinase (PAK) regulates PKD1 localization.
The spinal GTP-Rac1-PAK-ERK/p38MAPK signalling pathway is involved in both the development and maintenance of peripheral inflammatory pain and can be used as a potential molecular target for developing a novel therapeutic strategy for clinical pain
Title: Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection.
Nischarin inhibits neurite outgrowth by blocking PAK1 activation in neurons.
Title: Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity.
Data show that Smad3 protein transcriptional activation of E3 ubiquitin Llgase FBXO32 under stress is p21-activated kinase 1 Pak1 dependent in neonatal cardiomyocytes.
Title: Smad3 Couples Pak1 With the Antihypertrophic Pathway Through the E3 Ubiquitin Ligase, Fbxo32.
Cx43 increases serum induced filopodia formation via activation of p21-activated protein kinase 1.
Title: Cx43 increases serum induced filopodia formation via activation of p21-activated protein kinase 1.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC140666P2 (e-PCR)
- UniSTS:270955

Pak1 (e-PCR), detects polymorphism
- UniSTS:527474

AI072234 (e-PCR)
- UniSTS:244921

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	TAS Traceable Author Statement more info	PubMed
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISS Inferred from Sequence or Structural Similarity more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables gamma-tubulin binding	ISO Inferred from Sequence Orthology more info
enables gamma-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
contributes_to small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within amygdala development	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
involved_in branching morphogenesis of an epithelial tube	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within dendrite development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gamma-aminobutyric acid secretion, neurotransmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutamate secretion, neurotransmission	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell proliferation involved in contact inhibition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell proliferation involved in contact inhibition	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuromuscular junction development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within observational learning	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular estrogen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of microtubule nucleation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule nucleation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vascular associated smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein localization to cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in small GTPase-mediated signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info
involved_in wound healing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase PAK 1

Names: PAK-1; alpha-PAK; p21 (CDKN1A)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 1; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p68-PAK; protein kinase MUK2

NP_058894.1

EC 2.7.11.1

XP_006229814.1

EC 2.7.11.1

XP_006229815.1

EC 2.7.11.1

XP_006229816.1

EC 2.7.11.1

XP_038965324.1

EC 2.7.11.1

XP_063143586.1

EC 2.7.11.1

XP_063143587.1

EC 2.7.11.1

XP_063143590.1

EC 2.7.11.1

XP_063143594.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017198.2 → NP_058894.1 serine/threonine-protein kinase PAK 1

See identical proteins and their annotated locations for NP_058894.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P35465, Q62934

UniProtKB/TrEMBL

A0A8L2QLX9, A6I6C0

Conserved Domains (2) summary

cd06654
Location:248 → 543

STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1

pfam00786
Location:74 → 132

PBD; P21-Rho-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

161522399..161637623

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287516.1 → XP_063143586.1 serine/threonine-protein kinase PAK 1 isoform X1

UniProtKB/Swiss-Prot

P35465, Q62934

UniProtKB/TrEMBL

A6I6C0
XM_063287517.1 → XP_063143587.1 serine/threonine-protein kinase PAK 1 isoform X1

UniProtKB/Swiss-Prot

P35465, Q62934

UniProtKB/TrEMBL

A6I6C0
XM_039109396.1 → XP_038965324.1 serine/threonine-protein kinase PAK 1 isoform X1

UniProtKB/Swiss-Prot

P35465, Q62934

UniProtKB/TrEMBL

A0A8L2QLX9, A6I6C0

Conserved Domains (2) summary

cd06654
Location:248 → 543

STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1

pfam00786
Location:74 → 132

PBD; P21-Rho-binding domain
XM_006229754.5 → XP_006229816.1 serine/threonine-protein kinase PAK 1 isoform X1

See identical proteins and their annotated locations for XP_006229816.1

UniProtKB/Swiss-Prot

P35465, Q62934

UniProtKB/TrEMBL

A0A8L2QLX9, A6I6C0

Conserved Domains (2) summary

cd06654
Location:248 → 543

STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1

pfam00786
Location:74 → 132

PBD; P21-Rho-binding domain
XM_063287520.1 → XP_063143590.1 serine/threonine-protein kinase PAK 1 isoform X1

UniProtKB/Swiss-Prot

P35465, Q62934

UniProtKB/TrEMBL

A6I6C0
XM_063287524.1 → XP_063143594.1 serine/threonine-protein kinase PAK 1 isoform X1

UniProtKB/Swiss-Prot

P35465, Q62934

UniProtKB/TrEMBL

A6I6C0

Related

ENSRNOP00000073036.1, ENSRNOT00000091952.3
XM_006229752.4 → XP_006229814.1 serine/threonine-protein kinase PAK 1 isoform X1

See identical proteins and their annotated locations for XP_006229814.1

UniProtKB/Swiss-Prot

P35465, Q62934

UniProtKB/TrEMBL

A0A8L2QLX9, A6I6C0

Conserved Domains (2) summary

cd06654
Location:248 → 543

STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1

pfam00786
Location:74 → 132

PBD; P21-Rho-binding domain
XM_006229753.4 → XP_006229815.1 serine/threonine-protein kinase PAK 1 isoform X1

See identical proteins and their annotated locations for XP_006229815.1

UniProtKB/Swiss-Prot

P35465, Q62934

UniProtKB/TrEMBL

A0A8L2QLX9, A6I6C0

Conserved Domains (2) summary

cd06654
Location:248 → 543

STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1

pfam00786
Location:74 → 132

PBD; P21-Rho-binding domain