Slc38a5 solute carrier family 38, member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc38a5provided by RGD
Official Full Name: solute carrier family 38, member 5provided by RGD
Primary source: RGD:620702
See related: EnsemblRapid:ENSRNOG00000027767 AllianceGenome:RGD:620702
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SN2
Summary: Enables L-amino acid transmembrane transporter activity and neutral amino acid, sodium:proton antiporter activity. Involved in L-amino acid transport and amino acid export across plasma membrane. Located in plasma membrane. Orthologous to human SLC38A5 (solute carrier family 38 member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 79.9), Spleen (RPKM 66.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (16885701..16894470, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (14213727..14222498, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (14963919..14972675, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNAT5/SN2 expression is coordinated with that of other proteins necessary for the operation of glutamatergic synapses
Title: Expression of the System N transporter (SNAT5/SN2) during development indicates its plausible role in glutamatergic neurotransmission.
SN2 doubles as a transmitter precursor furnisher and a potential regulator of NMDA receptors.
Title: The system N transporter SN2 doubles as a transmitter precursor furnisher and a potential regulator of NMDA receptors.
The effect of lipopolysaccharides on system N expression occurs not only at the protein level, but also at the mRNA level
Title: Changes of plasma glutamine concentration and hepatocyte membrane system N transporters expression in early endotoxemia.
this transporter is likely to be involved in glutamatergic pathways in the brain.
Title: Amino acid transporter SNAT5 localizes to glial cells in the rat brain.
pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity allosteric regulation involves a conserved histidine residue
Title: Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-asparagine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamine, sodium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamine, sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables L-glutamine, sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamine, sodium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-histidine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-histidine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-serine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-serine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neutral amino acid, sodium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neutral amino acid, sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables neutral amino acid, sodium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-alanine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-glutamine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in L-glutamine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-glutamine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-glutamine import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-histidine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-histidine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-histidine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-serine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in L-serine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in asparagine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in asparagine transport	IEA Inferred from Electronic Annotation more info
involved_in glutamine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamine transport	ISO Inferred from Sequence Orthology more info
involved_in glycine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glycine transport	ISO Inferred from Sequence Orthology more info
involved_in inorganic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in neutral amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in serine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in serine transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sodium-coupled neutral amino acid transporter 5

Names: amino acid transporter system N2; system N transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431696.1 → NP_001418625.1 sodium-coupled neutral amino acid transporter 5 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

A2VCW5, Q91XR7

UniProtKB/TrEMBL

A6KP34
NM_138854.2 → NP_620209.2 sodium-coupled neutral amino acid transporter 5 isoform 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0H2UHW1, A6KP35

Related

ENSRNOP00000073818.1, ENSRNOT00000079664.3

Conserved Domains (1) summary

cl00456
Location:48 → 458

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

16885701..16894470 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008773068.4 → XP_008771290.2 sodium-coupled neutral amino acid transporter 5 isoform X1

Related

ENSRNOP00000038781.6, ENSRNOT00000038068.7

Conserved Domains (1) summary

cl00456
Location:56 → 466

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_039099444.2 → XP_038955372.1 sodium-coupled neutral amino acid transporter 5 isoform X2

UniProtKB/TrEMBL

A0A0H2UHW1

Conserved Domains (1) summary

cl00456
Location:39 → 449

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain