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    Psmc3 proteasome 26S subunit, ATPase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29677, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Psmc3provided by RGD
    Official Full Name
    proteasome 26S subunit, ATPase 3provided by RGD
    Primary source
    RGD:61905
    See related
    EnsemblRapid:ENSRNOG00000011414 AllianceGenome:RGD:61905
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and proteasome-activating activity. Predicted to be involved in modulation by host of viral transcription; positive regulation of transcription by RNA polymerase II; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within blastocyst development. Located in perinuclear region of cytoplasm. Orthologous to human PSMC3 (proteasome 26S subunit, ATPase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 344.2), Muscle (RPKM 247.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psmc3 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (97487643..97493025)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77031825..77037207)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (79876938..79882319)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene CUGBP, Elav-like family member 1 Neighboring gene receptor-associated protein of the synapse Neighboring gene solute carrier family 39 member 13 Neighboring gene uncharacterized LOC134486120 Neighboring gene uncharacterized LOC120101909

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A protein associated with the manchette during rat spermiogenesis is encoded by a gene of the TBP-1-like subfamily with highly conserved ATPase and protease domains. Rivkin E, et al. Mol Reprod Dev, 1997 Sep. PMID 9266764
    2. Rnf19a, a ubiquitin protein ligase, and Psmc3, a component of the 26S proteasome, tether to the acrosome membranes and the head-tail coupling apparatus during rat spermatid development. Rivkin E, et al. Dev Dyn, 2009 Jul. PMID 19517565
    3. The 19S ATPase S6a (S6'/TBP1) regulates the transcription initiation of class II transactivator. Truax AD, et al. J Mol Biol, 2010 Jan 15. PMID 19853614
    4. Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex. Ghee M, et al. J Neurochem, 2000 Nov. PMID 11032911
    5. A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator. Nelbock P, et al. Science, 1990 Jun 29. PMID 2194290

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rnf19a and Psmc3 may interact directly or indirectly with each other, presumably pointing to the participation of the ubiquitin-proteasome system in acrosome biogenesis, spermatid head shaping, and development of the head-tail coupling apparatus and tail.
      Title: Rnf19a, a ubiquitin protein ligase, and Psmc3, a component of the 26S proteasome, tether to the acrosome membranes and the head-tail coupling apparatus during rat spermatid development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proteasome-activating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation by host of viral transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome accessory complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome accessory complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    26S proteasome regulatory subunit 6A
    Names
    26S protease regulatory subunit 6A
    26S proteasome AAA-ATPase subunit RPT5
    TAT-binding protein 1
    TBP-1
    proteasome (prosome, macropain) 26S subunit, ATPase 3
    spermatogenic cell/sperm-associated TAT-binding protein homolog SATA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031595.2 → NP_113783.2  26S proteasome regulatory subunit 6A

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P97638, Q63569
      UniProtKB/TrEMBL
      A6HNA2, F7EY30, Q6P6U2
      Related
      ENSRNOP00000015757.2, ENSRNOT00000015757.5
      Conserved Domains (1) summary
      COG1222
      Location:28 → 435
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      97487643..97493025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104795.1 → XP_038960723.1  26S proteasome regulatory subunit 6A isoform X1

      Conserved Domains (1) summary
      COG1222
      Location:1 → 227
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63569.1 GenPept UniProtKB/Swiss-Prot:Q63569

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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