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    Prickle2 prickle planar cell polarity protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312563, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Prickle2provided by RGD
    Official Full Name
    prickle planar cell polarity protein 2provided by RGD
    Primary source
    RGD:1306723
    See related
    EnsemblRapid:ENSRNOG00000012364 AllianceGenome:RGD:1306723
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in several processes, including embryonic brain development; maintenance of postsynaptic density structure; and regulation of postsynaptic density assembly. Predicted to act upstream of or within establishment or maintenance of epithelial cell apical/basal polarity and neuron projection development. Predicted to be located in apicolateral plasma membrane; cytoplasm; and lateral plasma membrane. Predicted to be active in glutamatergic synapse and postsynaptic density. Orthologous to human PRICKLE2 (prickle planar cell polarity protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 144.5), Brain (RPKM 120.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prickle2 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (126426767..126771986, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (124869655..125214862, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (124238167..124584176, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692187 Neighboring gene uncharacterized LOC134486818 Neighboring gene rabenosyn, RAB effector Neighboring gene thyrotropin releasing hormone Neighboring gene uncharacterized LOC134486613 Neighboring gene uncharacterized LOC134486616 Neighboring gene uncharacterized LOC102554570 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2. Nagaoka T, et al. Sci Rep, 2015 Aug 10. PMID 26257100, Free PMC Article
    2. Prickle promotes neurite outgrowth via the Dishevelled dependent pathway in C1300 cells. Fujimura L, et al. Neurosci Lett, 2009 Dec 18. PMID 19788910
    3. Planar cell polarity signaling in vertebrates. Jones C, et al. Bioessays, 2007 Feb. PMID 17226800, Free PMC Article
    4. Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. Deans MR, et al. J Neurosci, 2007 Mar 21. PMID 17376975, Free PMC Article
    5. Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Tao H, et al. Dev Biol, 2012 Apr 15. PMID 22333836, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The PDZ interaction enhanced the protein interactions between PSD-95 and Prickle2, which is another planar cell polarity factor that is localised at the postsynaptic density.
      Title: PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment or maintenance of epithelial cell apical/basal polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of postsynaptic density structure ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic density assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to electrical stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apicolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    prickle-like protein 2
    Names
    prickle homolog 2
    prickle-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107876.3 → NP_001101346.1  prickle-like protein 2

      See identical proteins and their annotated locations for NP_001101346.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IBC5
      Conserved Domains (4) summary
      cd09415
      Location:130 → 188
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:193 → 248
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:253 → 311
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:26 → 122
      PET_Prickle; The PET domain of Prickle

    2. NM_001415880.2 → NP_001402809.1  prickle-like protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IBC5

    3. NM_001415881.2 → NP_001402810.1  prickle-like protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IBC5
      Related
      ENSRNOP00000104444.1, ENSRNOT00000155149.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      126426767..126771986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107621.2 → XP_038963549.1  prickle-like protein 2 isoform X2

      Conserved Domains (4) summary
      cd09415
      Location:186 → 244
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:249 → 304
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:309 → 367
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:82 → 178
      PET_Prickle; The PET domain of Prickle

    2. XM_039107620.2 → XP_038963548.1  prickle-like protein 2 isoform X1

      UniProtKB/TrEMBL
      F1M0J7
      Related
      ENSRNOP00000016628.7, ENSRNOT00000016628.8
      Conserved Domains (4) summary
      cd09415
      Location:222 → 280
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:285 → 340
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:345 → 403
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:118 → 214
      PET_Prickle; The PET domain of Prickle

    3. XM_039107624.2 → XP_038963552.1  prickle-like protein 2 isoform X3

      Conserved Domains (4) summary
      cd09415
      Location:222 → 280
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:285 → 340
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:345 → 403
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:118 → 214
      PET_Prickle; The PET domain of Prickle
    Nucleotide Protein Strain
    Heading Accession and Version

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