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    Togaram1 TOG array regulator of axonemal microtubules 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Togaram1provided by RGD
    Official Full Name
    TOG array regulator of axonemal microtubules 1provided by RGD
    Primary source
    RGD:1310474
    See related
    EnsemblRapid:ENSRNOG00000004415 AllianceGenome:RGD:1310474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam179b; RGD1310474
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in cilium assembly; microtubule cytoskeleton organization; and positive regulation of microtubule polymerization. Predicted to be located in axoneme; ciliary basal body; and microtubule. Predicted to be active in cilium and cytoplasmic microtubule. Human ortholog(s) of this gene implicated in Joubert syndrome. Orthologous to human TOGARAM1 (TOG array regulator of axonemal microtubules 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 113.0), Lung (RPKM 112.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Togaram1 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (88755264..88819599)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (83019025..83083343)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (86713588..86780134)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 14 open reading frame 28 Neighboring gene kelch-like family member 28 Neighboring gene pre-mRNA processing factor 39 Neighboring gene small nucleolar RNA, C/D box 127 Neighboring gene FKBP prolyl isomerase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crescerin uses a TOG domain array to regulate microtubules in the primary cilium. Das A, et al. Mol Biol Cell, 2015 Nov 15. PMID 26378256, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TOG array regulator of axonemal microtubules protein 1
    Names
    family with sequence similarity 179, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427294.1 → NP_001414223.1  TOG array regulator of axonemal microtubules protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      D4ABJ6
      Related
      ENSRNOP00000005861.6, ENSRNOT00000005861.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      88755264..88819599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_234236.11 → XP_234236.4  TOG array regulator of axonemal microtubules protein 1 isoform X1

      See identical proteins and their annotated locations for XP_234236.4

      UniProtKB/TrEMBL
      D3ZW60
      Related
      ENSRNOP00000056038.2, ENSRNOT00000059271.7
      Conserved Domains (2) summary
      pfam15402
      Location:789 → 905
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      sd00044
      Location:395 → 419
      HEAT; HEAT repeat [structural motif]

    2. XM_008764689.4 → XP_008762911.1  TOG array regulator of axonemal microtubules protein 1 isoform X2

      See identical proteins and their annotated locations for XP_008762911.1

      Related
      ENSRNOP00000091738.2, ENSRNOT00000106984.2
      Conserved Domains (2) summary
      pfam15402
      Location:789 → 905
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      sd00044
      Location:395 → 419
      HEAT; HEAT repeat [structural motif]

    3. XM_006240139.5 → XP_006240201.1  TOG array regulator of axonemal microtubules protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006240201.1

      UniProtKB/TrEMBL
      A0A8I6AG72
      Related
      ENSRNOP00000108794.1, ENSRNOT00000123748.1
      Conserved Domains (2) summary
      pfam15402
      Location:789 → 905
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      sd00044
      Location:395 → 419
      HEAT; HEAT repeat [structural motif]

    4. XM_063261915.1 → XP_063117985.1  TOG array regulator of axonemal microtubules protein 1 isoform X4

    5. XM_039113217.2 → XP_038969145.1  TOG array regulator of axonemal microtubules protein 1 isoform X5

      Conserved Domains (1) summary
      sd00044
      Location:395 → 419
      HEAT; HEAT repeat [structural motif]

    6. XM_039113218.2 → XP_038969146.1  TOG array regulator of axonemal microtubules protein 1 isoform X7

      Conserved Domains (1) summary
      sd00044
      Location:395 → 419
      HEAT; HEAT repeat [structural motif]

    7. XM_063261916.1 → XP_063117986.1  TOG array regulator of axonemal microtubules protein 1 isoform X6

    RNA

    1. XR_010052087.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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