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    Igsf11 immunoglobulin superfamily, member 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303926, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Igsf11provided by RGD
    Official Full Name
    immunoglobulin superfamily, member 11provided by RGD
    Primary source
    RGD:1308758
    See related
    EnsemblRapid:ENSRNOG00000001525 AllianceGenome:RGD:1308758
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ionotropic glutamate receptor binding activity. Involved in maintenance of protein location; positive regulation of mini excitatory postsynaptic potential; and regulation of postsynaptic membrane neurotransmitter receptor levels. Located in excitatory synapse and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human IGSF11 (immunoglobulin superfamily member 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 178.8), Kidney (RPKM 164.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Igsf11 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (75238706..75389748, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (61733139..61884059, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (64286691..64421248, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352339 Neighboring gene uncharacterized LOC134481003 Neighboring gene U6 spliceosomal RNA Neighboring gene peroxiredoxin 6, pseudogene 3 Neighboring gene ribosomal protein L27 like 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule. Harada H, et al. J Cell Physiol, 2005 Sep. PMID 15795899
    2. Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. Watanabe T, et al. Cancer Sci, 2005 Aug. PMID 16108831, Free PMC Article
    3. Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity. Jang S, et al. Nat Neurosci, 2016 Jan. PMID 26595655, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94879

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in maintenance of protein location IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mini excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in trans-synaptic signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in excitatory synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    immunoglobulin superfamily member 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013120.1 → NP_001013138.1  immunoglobulin superfamily member 11 precursor

      See identical proteins and their annotated locations for NP_001013138.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085929
      UniProtKB/Swiss-Prot
      Q5U2P2
      Related
      ENSRNOP00000059779.1, ENSRNOT00000066997.4
      Conserved Domains (3) summary
      smart00410
      Location:29 → 124
      IG_like; Immunoglobulin like
      pfam07686
      Location:27 → 141
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:156 → 223
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      75238706..75389748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270528.1 → XP_063126598.1  immunoglobulin superfamily member 11 isoform X1

      Related
      ENSRNOP00000105601.1, ENSRNOT00000124458.1

    2. XM_039088359.2 → XP_038944287.1  immunoglobulin superfamily member 11 isoform X1

      Conserved Domains (3) summary
      pfam13927
      Location:99 → 160
      Ig_3; Immunoglobulin domain
      cd00096
      Location:13 → 18
      Ig; Ig strand C' [structural motif]
      cl11960
      Location:5 → 67
      Ig; Immunoglobulin domain

    3. XM_039088360.2 → XP_038944288.1  immunoglobulin superfamily member 11 isoform X1

      Conserved Domains (3) summary
      pfam13927
      Location:99 → 160
      Ig_3; Immunoglobulin domain
      cd00096
      Location:13 → 18
      Ig; Ig strand C' [structural motif]
      cl11960
      Location:5 → 67
      Ig; Immunoglobulin domain

    4. XM_063270530.1 → XP_063126600.1  immunoglobulin superfamily member 11 isoform X3

    5. XM_063270529.1 → XP_063126599.1  immunoglobulin superfamily member 11 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2P2.1 GenPept UniProtKB/Swiss-Prot:Q5U2P2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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