Kif5a kinesin family member 5A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif5aprovided by RGD
Official Full Name: kinesin family member 5Aprovided by RGD
Primary source: RGD:1303035
See related: EnsemblRapid:ENSRNOG00000005299 AllianceGenome:RGD:1303035
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables scaffold protein binding activity. Involved in several processes, including axonal transport; cellular response to ethanol; and forebrain development. Located in several cellular components, including P-body; central region of growth cone; and perikaryon. Part of kinesin complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 25; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Orthologous to human KIF5A (kinesin family member 5A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1106.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (64937210..64974339, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (63051894..63089024, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (70515832..70552897, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kif5a Regulates Mitochondrial Transport in Developing Retinal Ganglion Cells In Vitro.
Title: Kif5a Regulates Mitochondrial Transport in Developing Retinal Ganglion Cells In Vitro.
HIF1alpha protects PC12 cells from OGD/Rinduced cell injury by regulating autophagy flux through the miR20a5p/KIF5A axis.
Title: HIF‑1α protects PC12 cells from OGD/R‑induced cell injury by regulating autophagy flux through the miR‑20a‑5p/KIF5A axis.
A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression.
Title: A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression.
HDAC-dependent regulatory circuit that promotes formation of JIP1:KIF5A:microtubule complexes that regulate intracellular transport of cargo such as autophagosomes, is reported.
Title: Class I HDACs control a JIP1-dependent pathway for kinesin-microtubule binding in cardiomyocytes.
The results of this study showed that Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5
Title: Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5.
kinesin-5 regulates the rate and directionality of neuronal migration and possibly the cessation of migration when the neuron reaches its destination.
Title: Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration.
Kinesin-12 shares functions with kinesin-5 related to microtubule-microtubule interactions, but kinesin-12 has other functions not shared by kinesin-5 that are related to the ability of kinesin-12 to interact with actin.
Title: Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching.
Data suggest that HAP1-KIF5-dependent GABA(A)R trafficking is a fundamental mechanism controlling the strength of synaptic inhibition in the brain.
Title: Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kif5a (e-PCR), detects polymorphism
- UniSTS:507010

BF388221 (e-PCR)
- UniSTS:244872

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinesin binding	IEA Inferred from Electronic Annotation more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	TAS Traceable Author Statement more info	PubMed
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IEA Inferred from Electronic Annotation more info
involved_in anterograde dendritic transport of neurotransmitter receptor complex	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based process	TAS Traceable Author Statement more info	PubMed
involved_in neuron development	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to rotenone	IEP Inferred from Expression Pattern more info	PubMed
involved_in retrograde neuronal dense core vesicle transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in thalamus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in apical dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in central region of growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary rootlet	IEA Inferred from Electronic Annotation more info
located_in ciliary rootlet	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	TAS Traceable Author Statement more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in postsynaptic cytosol	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin heavy chain isoform 5A

Names: NKHC; kinesin heavy chain neuron-specific 1; neuronal kinesin heavy chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212523.1 → NP_997688.1 kinesin heavy chain isoform 5A

See identical proteins and their annotated locations for NP_997688.1

Status: PROVISIONAL

Source sequence(s)

AY535015

UniProtKB/Swiss-Prot

Q6QLM7

UniProtKB/TrEMBL

A0A0G2K0Q2

Related

ENSRNOP00000071539.1, ENSRNOT00000080594.3

Conserved Domains (5) summary

smart00129
Location:9 → 334

KISc; Kinesin motor, catalytic domain. ATPase

cd14798
Location:441 → 493

RX-CC_like; Coiled-coil domain of the potato virux X resistance protein and similar proteins

cd01369
Location:7 → 327

KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup

pfam05010
Location:713 → 884

TACC; Transforming acidic coiled-coil-containing protein (TACC)

cl12013
Location:637 → 809

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature