Fmnl3 formin-like 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fmnl3provided by RGD
Official Full Name: formin-like 3provided by RGD
Primary source: RGD:1583854
See related: EnsemblRapid:ENSRNOG00000056297 AllianceGenome:RGD:1583854
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase activating protein binding activity and actin filament binding activity. Predicted to be involved in several processes, including cortical actin cytoskeleton organization; filopodium assembly; and regulation of cell shape. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in cytosol. Orthologous to human FMNL3 (formin like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 187.5), Lung (RPKM 179.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (132333130..132384483, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (130454270..130505626, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (140981801..141033318, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH141606 (e-PCR)
- UniSTS:223600

RH141727 (e-PCR)
- UniSTS:223720

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activating protein binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cortical actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: formin-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399766.1 → NP_001386695.1 formin-like protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6A3S6

Related

ENSRNOP00000085382.1, ENSRNOT00000101420.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

132333130..132384483 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263386.1 → XP_063119456.1 formin-like protein 3 isoform X2

UniProtKB/TrEMBL

A0A8I6ART4

Related

ENSRNOP00000097005.1, ENSRNOT00000106042.2
XM_039080568.2 → XP_038936496.1 formin-like protein 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZLE1

Conserved Domains (3) summary

pfam06367
Location:237 → 434

Drf_FH3; Diaphanous FH3 Domain

pfam02181
Location:518 → 883

FH2; Formin Homology 2 Domain

pfam06371
Location:1 → 234

Drf_GBD; Diaphanous GTPase-binding Domain
XM_039080569.1 → XP_038936497.1 formin-like protein 3 isoform X3

UniProtKB/TrEMBL

A0A8I5ZLE1

Conserved Domains (3) summary

pfam06367
Location:135 → 332

Drf_FH3; Diaphanous FH3 Domain

pfam02181
Location:416 → 781

FH2; Formin Homology 2 Domain

pfam06371
Location:66 → 132

Drf_GBD; Diaphanous GTPase-binding Domain
XM_003752125.6 → XP_003752173.1 formin-like protein 3 isoform X2

UniProtKB/TrEMBL

A0A0G2JXC2, A0A8I6ART4

Related

ENSRNOP00000078509.2, ENSRNOT00000105112.2

Conserved Domains (3) summary

pfam02181
Location:562 → 927

FH2; Formin Homology 2 Domain

pfam06367
Location:281 → 478

Drf_FH3; Diaphanous FH3 Domain

pfam06371
Location:26 → 278

Drf_GBD; Diaphanous GTPase-binding Domain