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    Tspan7 tetraspanin 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363447, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tspan7provided by RGD
    Official Full Name
    tetraspanin 7provided by RGD
    Primary source
    RGD:1589725
    See related
    EnsemblRapid:ENSRNOG00000003229 AllianceGenome:RGD:1589725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    A15; MXS1; Tm4sf2; TALLA-1; DXS1692E
    Summary
    Involved in regulation of postsynaptic neurotransmitter receptor internalization. Is active in postsynapse. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 58. Orthologous to human TSPAN7 (tetraspanin 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 1674.6), Lung (RPKM 1213.9) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tspan7 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (14881327..14978627, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (12208783..12306092, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (13261551..13282886, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484143 Neighboring gene uncharacterized LOC120099251 Neighboring gene MID1 interacting protein 1 Neighboring gene elongation factor 1-gamma pseudogene Neighboring gene U2 spliceosomal RNA Neighboring gene RIKEN cDNA 4933416E14 gene like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats. Pang S, et al. Life Sci Alliance, 2023 Mar. PMID 36625203, Free PMC Article
    2. The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking. Bassani S, et al. Neuron, 2012 Mar 22. PMID 22445342, Free PMC Article
    3. Functional identification of neuroprotective molecules. Dai C, et al. PLoS One, 2010 Nov 24. PMID 21124846, Free PMC Article
    4. Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes. Kuroiwa A, et al. Cytogenet Cell Genet, 1998. PMID 9730605
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Integrin beta1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats.
      Title: Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetraspanin-7
    Names
    Transmembrane 4, superfamily member 2 (cell surface glycoprotein A15)
    neuroprotective protein 5
    transmembrane 4 superfamily member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398737.1 → NP_001385666.1  tetraspanin-7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A9K3Y7X8, B0BNE7, F1M9I6
      Related
      ENSRNOP00000057580.5, ENSRNOT00000060857.7
      Conserved Domains (2) summary
      cd03161
      Location:110 → 213
      TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:15 → 237
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      14881327..14978627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108815.1: Suppressed sequence

      Description
      NM_001108815.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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