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    Rbm3 RNA binding motif protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114488, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rbm3provided by RGD
    Official Full Name
    RNA binding motif protein 3provided by RGD
    Primary source
    RGD:620145
    See related
    EnsemblRapid:ENSRNOG00000005387 AllianceGenome:RGD:620145
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity and ribosomal large subunit binding activity. Involved in positive regulation of translation. Located in cytoplasm; dendrite; and nucleus. Part of large ribosomal subunit. Orthologous to human RBM3 (RNA binding motif protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 1338.6), Spleen (RPKM 1167.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rbm3 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17020863..17024341)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14348909..14352387)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15098880..15102344)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene EBP, cholestenol delta-isomerase Neighboring gene TBC1 domain family, member 25 Neighboring gene WD repeat domain 13 Neighboring gene U6 spliceosomal RNA Neighboring gene WASP actin nucleation promoting factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC105811

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosomal large subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to cold ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within translation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    RNA-binding protein 3
    Names
    RNA binding motif (RNP1, RRM) protein 3
    putative RNA-binding protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053696.1NP_446148.1  RNA-binding protein 3

      See identical proteins and their annotated locations for NP_446148.1

      Status: VALIDATED

      Source sequence(s)
      AF355190, CA340698, DN933310, DY319481
      UniProtKB/Swiss-Prot
      Q925G0
      UniProtKB/TrEMBL
      A6KP47, G3V6P6
      Related
      ENSRNOP00000007367.4, ENSRNOT00000007367.8
      Conserved Domains (1) summary
      cd12449
      Location:685
      RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      17020863..17024341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256694.3XP_006256756.1  RNA-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006256756.1

      UniProtKB/Swiss-Prot
      Q925G0
      UniProtKB/TrEMBL
      A6KP47, G3V6P6
      Conserved Domains (1) summary
      cd12449
      Location:685
      RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins
    2. XM_006256695.3XP_006256757.1  RNA-binding protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006256757.1

      UniProtKB/Swiss-Prot
      Q925G0
      Conserved Domains (1) summary
      cd12449
      Location:685
      RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins
    3. XM_006256696.3XP_006256758.1  RNA-binding protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006256758.1

      UniProtKB/Swiss-Prot
      Q925G0
      Conserved Domains (1) summary
      cd12449
      Location:685
      RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins
    4. XM_063279735.1XP_063135805.1  RNA-binding protein 3 isoform X3

    5. XM_063279736.1XP_063135806.1  RNA-binding protein 3 isoform X3