Cga glycoprotein hormones, alpha polypeptide [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cgaprovided by RGD
Official Full Name: glycoprotein hormones, alpha polypeptideprovided by RGD
Primary source: RGD:620436
See related: AllianceGenome:RGD:620436
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpa1
Summary: Predicted to enable follicle-stimulating hormone activity. Predicted to be involved in several processes, including positive regulation of steroid biosynthetic process; regulation of signaling receptor activity; and thyroid hormone generation. Predicted to act upstream of or within several processes, including gonadotropin secretion; negative regulation of organ growth; and thyroid gland development. Predicted to be part of follicle-stimulating hormone complex. Predicted to be active in extracellular space. Orthologous to human CGA (glycoprotein hormones, alpha polypeptide). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 1.3), Uterus (RPKM 0.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (54283109..54295464)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (49486915..49499192)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (50362491..50393368)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that FSH (Cga/FSHb) induces clock system in granulosa cells by up-regulation of connexin 43 expression; this suggests that gap junctions are implicated in circadian clock in peripheral oscillators besides central pacemaker.
Title: FSH induces the development of circadian clockwork in rat granulosa cells via a gap junction protein Cx43-dependent pathway.
Complex interactions between Ahr and Esr alter Prl and luteinizing hormone (LH) synthesis by direct actions in lactotropes and gonadotropes.
Title: Aryl hydrocarbon receptor activation in lactotropes and gonadotropes interferes with estradiol-dependent and -independent preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression.
histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter
Title: Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables follicle-stimulating hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables follicle-stimulating hormone activity	ISO Inferred from Sequence Orthology more info
enables follicle-stimulating hormone activity	ISS Inferred from Sequence or Structural Similarity more info
enables hormone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cellular response to hormone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within developmental growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within follicle-stimulating hormone secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gonad development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within luteinizing hormone secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of organ growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of organ growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of steroid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of steroid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within thyroid gland development	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone generation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within thyroid hormone generation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
part_of follicle-stimulating hormone complex	IBA Inferred from Biological aspect of Ancestor more info
part_of follicle-stimulating hormone complex	ISO Inferred from Sequence Orthology more info
part_of follicle-stimulating hormone complex	ISS Inferred from Sequence or Structural Similarity more info
part_of pituitary gonadotropin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glycoprotein hormones alpha chain

Names: FSH-alpha; LSH-alpha; TSH-alpha; anterior pituitary glycoprotein hormones common subunit alpha; follicle-stimulating hormone alpha chain; follitropin alpha chain; glycoprotein hormone alpha subunit; glycoprotein hormones, alpha subunit; luteinizing hormone alpha chain; lutropin alpha chain; pituitary hormone alpha subunit; thyroid-stimulating hormone alpha chain; thyrotropin alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053918.3 → NP_446370.3 glycoprotein hormones alpha chain precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P11962, P70516

UniProtKB/TrEMBL

A0A0F7RQ24

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

54283109..54295464

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287073.1 → XP_063143143.1 glycoprotein hormones alpha chain isoform X1

UniProtKB/Swiss-Prot

P11962, P70516

UniProtKB/TrEMBL

A0A0F7RQ24
XM_063287072.1 → XP_063143142.1 glycoprotein hormones alpha chain isoform X1

UniProtKB/Swiss-Prot

P11962, P70516

UniProtKB/TrEMBL

A0A0F7RQ24