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    Kcnh3 potassium voltage-gated channel subfamily H member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 27150, updated on 27-Nov-2024

    Summary

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    Symbol
    Kcnh3provided by RGD
    Full Name
    potassium voltage-gated channel subfamily H member 3provided by RGD
    Primary source
    RGD:71070
    See related
    EnsemblRapid:ENSRNOG00000057315 AllianceGenome:RGD:71070
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bec1; Elk2
    Summary
    Enables inward rectifier potassium channel activity. Involved in potassium ion transport. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNH3 (potassium voltage-gated channel subfamily H member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 91.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnh3 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (132244492..132262725)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130365593..130383859)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140788987..140910426)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C22 Neighboring gene spermatogenesis associated, serine-rich 2 Neighboring gene U1 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA70 Neighboring gene microspherule protein 1 Neighboring gene pre-mRNA processing factor 40 homolog B Neighboring gene family with sequence similarity 186, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional expression of rat ether-à-go-go-like K+ channel genes. Engeland B, et al. J Physiol, 1998 Dec 15. PMID 9824707, Free PMC Article
    2. Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia. Shi W, et al. J Physiol, 1998 Sep 15. PMID 9714851, Free PMC Article
    3. New ether-à-go-go K(+) channel family members localized in human telencephalon. Miyake A, et al. J Biol Chem, 1999 Aug 27. PMID 10455180
    4. Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary. Wulfsen I, et al. J Neuroendocrinol, 2000 Mar. PMID 10718922
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated inwardly rectifying potassium channel KCNH3; potassium voltage-gated channel subfamily H member 3
    Names
    ELK channel 2
    brain-specific eag-like channel 1
    ether-a-go-go-like potassium channel 2
    potassium channel, voltage gated eag related subfamily H, member 3
    potassium voltage-gated channel, subfamily H (eag-related), member 3
    rElk2
    voltage-gated potassium channel subunit Kv12.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017108.1 → NP_058804.1  voltage-gated inwardly rectifying potassium channel KCNH3

      See identical proteins and their annotated locations for NP_058804.1

      Status: PROVISIONAL

      Source sequence(s)
      AB022697
      UniProtKB/Swiss-Prot
      O89047
      Related
      ENSRNOP00000071001.1, ENSRNOT00000086611.3
      Conserved Domains (5) summary
      cd00038
      Location:585 → 695
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:42 → 133
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:246 → 514
      Ion_trans; Ion transport protein
      pfam07885
      Location:455 → 509
      Ion_trans_2; Ion channel
      pfam08447
      Location:42 → 123
      PAS_3; PAS fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      132244492..132262725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078511.2 → XP_038934439.1  potassium voltage-gated channel subfamily H member 3 isoform X1

      Conserved Domains (3) summary
      PLN03192
      Location:167 → 594
      PLN03192; Voltage-dependent potassium channel; Provisional
      PRK13557
      Location:4 → 74
      PRK13557; histidine kinase; Provisional
      TIGR03896
      Location:549 → 644
      cyc_nuc_ocin; bacteriocin-type transport-associated protein

    2. XM_017594683.3 → XP_017450172.1  potassium voltage-gated channel subfamily H member 3 isoform X1

      Conserved Domains (3) summary
      PLN03192
      Location:167 → 594
      PLN03192; Voltage-dependent potassium channel; Provisional
      PRK13557
      Location:4 → 74
      PRK13557; histidine kinase; Provisional
      TIGR03896
      Location:549 → 644
      cyc_nuc_ocin; bacteriocin-type transport-associated protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O89047.1 GenPept UniProtKB/Swiss-Prot:O89047

    Gene LinkOut

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