AXL AXR1-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: AXL
Official Full Name: AXR1-like protein
Primary source: TAIR:AT2G32410
Locus tag: AT2G32410
See related: Araport:AT2G32410
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AXL1; AXR1- like 1; AXR1-like; T32F6.7; T32F6_7
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See AXL in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 14

Sequence:: Chromosome: 2; NC_003071.7 (13757593..13761152)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AXR1 and AXL1 differ in ability to correct phenotypic defects in axr1-30, a severe loss-of-function AXR1 mutant, when the respective coding sequences are expressed from the same promoter, suggesting differential in vivo functions.
Title: AXR1-ECR1 and AXL1-ECR1 heterodimeric RUB-activating enzymes diverge in function in Arabidopsis thaliana.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_001036388.1

Supported by ESTs:

NM_001336394.1

Supported by ESTs:

NM_128800.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NEDD8 activating enzyme activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein neddylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

Go to the top of the page Help

Preferred Names: AXR1-like protein

NP_001031465.1

AXR1-like (AXL); FUNCTIONS IN: binding, catalytic activity; INVOLVED IN: auxin homeostasis, auxin mediated signaling pathway, post-embryonic development, protein ubiquitination; LOCATED IN: peroxisome; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT1G05180.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_180800.1

AXR1-like (AXL); FUNCTIONS IN: binding, catalytic activity; INVOLVED IN: auxin homeostasis, auxin mediated signaling pathway, post-embryonic development, protein ubiquitination; LOCATED IN: peroxisome; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT1G05180.1); Has 6613 Blast hits to 5967 proteins in 1376 species: Archae - 160; Bacteria - 2652; Metazoa - 1238; Fungi - 918; Plants - 479; Viruses - 0; Other Eukaryotes - 1166 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

13757593..13761152

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128800.4 → NP_180800.1 AXR1-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180800.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9ZV69

UniProtKB/TrEMBL

A0A178VWM3, A0A5S9X394, A0A654EZJ5

Conserved Domains (1) summary

cd01493
Location:6 → 521

APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
NM_001336394.1 → NP_001325390.1 AXR1-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B315
NM_001036388.1 → NP_001031465.1 AXR1-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031465.1

Status: REVIEWED

UniProtKB/TrEMBL

F4ITQ5

Conserved Domains (2) summary

COG0476
Location:7 → 159

ThiF; Molybdopterin or thiamine biosynthesis adenylyltransferase [Coenzyme transport and metabolism]

cd01493
Location:6 → 387

APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...