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    HCS1 holocarboxylase synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817112, updated on 18-Sep-2024

    Summary

    Official Symbol
    HCS1
    Official Full Name
    holocarboxylase synthase 1
    Primary source
    TAIR:AT2G25710
    Locus tag
    AT2G25710
    See related
    Araport:AT2G25710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F3N11.16; F3N11_16; HOLOCARBOXYLASE SYNTHASE; holocarboxylase synthase 1
    Summary
    Encodes a dual-targeted biotin holocarboxylase synthetase that can localize to the chloroplast and the cytosol. In vitro, it has been shown to catalyze the addition of biotin to the BCCP subunit of acetyl-CoA carboxylase and it can also biotinylate methylcrotonyl-CoA carboxylase. A small upstream ORF in the 5'UTR (uORF24) regulates the differential targeting of this enzyme.
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    Genomic context

    See HCS1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (10952547..10955411)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene DUF581 family protein, putative (DUF581) Neighboring gene SKP1-like 3 Neighboring gene uncharacterized protein Neighboring gene zinc finger FYVE domain protein

    Pathways from PubChem

    General gene information

    NM_001336012.1
    NM_001336013.1
    NM_001336014.1
    NM_001336015.1
    NM_001336016.1
    NM_128130.3
    NM_179736.1

    Gene Ontology Provided by TAIR

    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    holocarboxylase synthase 1
    NP_565605.1
    • holocarboxylase synthase 1 (HCS1); FUNCTIONS IN: biotin-[acetyl-CoA-carboxylase] ligase activity, catalytic activity; INVOLVED IN: protein modification process; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Biotin protein ligase, C-terminal (InterPro:IPR003142), Biotin/lipoate A/B protein ligase (InterPro:IPR004143), Biotin--acetyl-CoA-carboxylase ligase (InterPro:IPR004408); BEST Arabidopsis thaliana protein match is: holocarboxylase synthetase 2 (TAIR:AT1G37150.2); Has 6062 Blast hits to 6058 proteins in 2314 species: Archae - 226; Bacteria - 4056; Metazoa - 119; Fungi - 135; Plants - 62; Viruses - 0; Other Eukaryotes - 1464 (source: NCBI BLink).
    NP_850067.1
    • holocarboxylase synthase 1 (HCS1); FUNCTIONS IN: biotin-[acetyl-CoA-carboxylase] ligase activity, catalytic activity; INVOLVED IN: protein modification process; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Biotin protein ligase, C-terminal (InterPro:IPR003142), Biotin/lipoate A/B protein ligase (InterPro:IPR004143), Biotin--acetyl-CoA-carboxylase ligase (InterPro:IPR004408); BEST Arabidopsis thaliana protein match is: holocarboxylase synthetase 2 (TAIR:AT1G37150.2); Has 6039 Blast hits to 6035 proteins in 2305 species: Archae - 225; Bacteria - 4034; Metazoa - 119; Fungi - 135; Plants - 62; Viruses - 0; Other Eukaryotes - 1464 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10952547..10955411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336011.1NP_001324826.1  holocarboxylase synthase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQX4, A0A1P8B1A6
    2. NM_128130.3NP_565605.1  holocarboxylase synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565605.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P92975, Q8S4V8, Q9SL92
      UniProtKB/TrEMBL
      A0A5S9X1E4
      Conserved Domains (2) summary
      cd16442
      Location:113288
      BPL; biotin protein ligase
      pfam02237
      Location:306360
      BPL_C; Biotin protein ligase C terminal domain
    3. NM_001336012.1NP_001324829.1  holocarboxylase synthase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VMU1, A0A5S9X1E4
      Conserved Domains (2) summary
      cd16442
      Location:75250
      BPL; biotin protein ligase
      pfam02237
      Location:268323
      BPL_C; Biotin protein ligase C terminal domain
    4. NM_001336013.1NP_001324830.1  holocarboxylase synthase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VMU1, A0A5S9X1E4
      Conserved Domains (2) summary
      cd16442
      Location:75250
      BPL; biotin protein ligase
      pfam02237
      Location:268323
      BPL_C; Biotin protein ligase C terminal domain
    5. NM_001336014.1NP_001324827.1  holocarboxylase synthase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQX4, A0A1P8B1A4
    6. NM_001336015.1NP_001324828.1  holocarboxylase synthase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQX4, A0A1P8B1A4
    7. NM_001336016.1NP_001324831.1  holocarboxylase synthase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQX4, A0A1P8B1A6
    8. NM_179736.1NP_850067.1  holocarboxylase synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850067.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P92975, Q8S4V8, Q9SL92
      UniProtKB/TrEMBL
      A0A5S9X1E4
      Conserved Domains (2) summary
      cd16442
      Location:113288
      BPL; biotin protein ligase
      pfam02237
      Location:306360
      BPL_C; Biotin protein ligase C terminal domain