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    HYL1 dsRNA-binding domain-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837498, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HYL1
    Official Full Name
    dsRNA-binding domain-like superfamily protein
    Primary source
    TAIR:AT1G09700
    Locus tag
    AT1G09700
    See related
    Araport:AT1G09700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtDRB1; DRB1; DSRNA-BINDING PROTEIN 1; F21M12.9; F21M12_9; HYPONASTIC LEAVES 1
    Summary
    Encodes a nuclear dsRNA binding protein. Involved in mRNA cleavage. The mutant is characterized by shorter stature, delayed flowering, leaf hyponasty, reduced fertility, decreased rate of root growth, and an altered root gravitropic response. It also exhibits less sensitivity to auxin and cytokinin.
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    Genomic context

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    See HYL1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (3137649..3140353, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Toll-Interleukin-Resistance (TIR) domain family protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Translation protein SH3-like family protein Neighboring gene Homeodomain-like superfamily protein Neighboring gene Kinase interacting (KIP1-like) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Solution structure and behaviour of the Arabidopsis thaliana HYL1 protein. Wieczorek P, et al. Biochim Biophys Acta Gen Subj, 2023 Aug. PMID 37150226
    2. A mutation in the Arabidopsis HYL1 gene encoding a dsRNA binding protein affects responses to abscisic acid, auxin, and cytokinin. Lu C, et al. Plant Cell, 2000 Dec. PMID 11148283, Free PMC Article
    3. The nuclear dsRNA binding protein HYL1 is required for microRNA accumulation and plant development, but not posttranscriptional transgene silencing. Vazquez F, et al. Curr Biol, 2004 Feb 17. PMID 14972688
    4. The N-terminal double-stranded RNA binding domains of Arabidopsis HYPONASTIC LEAVES1 are sufficient for pre-microRNA processing. Wu F, et al. Plant Cell, 2007 Mar. PMID 17337628, Free PMC Article
    5. Gene structures and processing of Arabidopsis thaliana HYL1-dependent pri-miRNAs. Szarzynska B, et al. Nucleic Acids Res, 2009 May. PMID 19304749, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Solution structure and behaviour of the Arabidopsis thaliana HYL1 protein.
      Title: Solution structure and behaviour of the Arabidopsis thaliana HYL1 protein.
    2. HYPONASTIC LEAVES 1 is required for proper establishment of auxin gradient in apical hooks.
      Title: HYPONASTIC LEAVES 1 is required for proper establishment of auxin gradient in apical hooks.
    3. Cytoplasmic HYL1 modulates miRNA-mediated translational repression.
      Title: Cytoplasmic HYL1 modulates miRNA-mediated translational repression.
    4. Light-stabilized FHA2 suppresses miRNA biogenesis through interactions with DCL1 and HYL1.
      Title: Light-stabilized FHA2 suppresses miRNA biogenesis through interactions with DCL1 and HYL1.
    5. The Intrinsically Disordered Protein CARP9 Bridges HYL1 to AGO1 in the Nucleus to Promote MicroRNA Activity.
      Title: The Intrinsically Disordered Protein CARP9 Bridges HYL1 to AGO1 in the Nucleus to Promote MicroRNA Activity.
    6. Dual function of HYPONASTIC LEAVES 1 during early skotomorphogenic growth in Arabidopsis.
      Title: Dual function of HYPONASTIC LEAVES 1 during early skotomorphogenic growth in Arabidopsis.
    7. Hyponastic Leaves 1 protects pri-miRNAs from nuclear exosome attack.
      Title: Hyponastic Leaves 1 protects pri-miRNAs from nuclear exosome attack.
    8. The selection of these GC signatures was dependent on an RNA binding protein partner of DCL1 named HYL1.
      Title: A conserved sequence signature is essential for robust plant miRNA biogenesis.
    9. The transcriptional response of select ER stress-responsive genes in hyl1 mutant plants was indistinguishable from that of wild-type plants, suggesting that the loss-of-function of HYL1 does not affect the ER stress signaling pathways.
      Title: Deficiency in the double-stranded RNA binding protein HYPONASTIC LEAVES1 increases sensitivity to the endoplasmic reticulum stress inducer tunicamycin in Arabidopsis.
    10. fiery1, hyl1 and se interact and require miRNA precursor processing in Arabidopsis
      Title: Efficiency and precision of microRNA biogenesis modes in plants.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001331846.1
    NM_100842.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within leaf proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf vascular tissue pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within miRNA-mediated gene silencing by mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pre-miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokinin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ta-siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear dicing body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    dsRNA-binding domain-like superfamily protein
    NP_563850.1
    • HYPONASTIC LEAVES 1 (HYL1); CONTAINS InterPro DOMAIN/s: Double-stranded RNA-binding (InterPro:IPR001159), Double-stranded RNA-binding-like (InterPro:IPR014720); BEST Arabidopsis thaliana protein match is: dsRNA-binding protein 2 (TAIR:AT2G28380.1); Has 992 Blast hits to 893 proteins in 320 species: Archae - 14; Bacteria - 506; Metazoa - 117; Fungi - 6; Plants - 270; Viruses - 0; Other Eukaryotes - 79 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3137649..3140353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100842.4 → NP_563850.1  dsRNA-binding domain-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563850.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z3F9, O04492
      Conserved Domains (1) summary
      cd00048
      Location:16 → 82
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

    2. NM_001331846.1 → NP_001321280.1  dsRNA-binding domain-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AQD8, A0A7G2DT78
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04492.1

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