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    CPK2 calmodulin-domain protein kinase cdpk isoform 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820235, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CPK2
    Official Full Name
    calmodulin-domain protein kinase cdpk isoform 2
    Primary source
    TAIR:AT3G10660
    Locus tag
    AT3G10660
    See related
    Araport:AT3G10660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCPK2; calmodulin-domain protein kinase cdpk isoform 2
    Summary
    predicted to encode calcium-dependent protein kinase and is localized to the ER. Protein is myristoylated in a cell-free extract. Changing the proposed myristoylated site, G residue in the amino terminal, to A prevented the meristoylation . The G to A mutation decreased AtCPK2 membrane association by approximately 50%.
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    Genomic context

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    See CPK2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Sequence:
    Chromosome: 3; NC_003074.8 (3331064..3334986, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene UDP-Glycosyltransferase superfamily protein Neighboring gene ncRNA Neighboring gene SNF7 family protein Neighboring gene nuclear pore complex protein Neighboring gene non-intrinsic ABC protein 7 Neighboring gene HSP20-like chaperones superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Arabidopsis calcium-dependent protein kinase is associated with the endoplasmic reticulum. Lu SX, et al. Plant Physiol, 2002 Mar. PMID 11891256, Free PMC Article
    2. Pollen tube growth regulation by free anions depends on the interaction between the anion channel SLAH3 and calcium-dependent protein kinases CPK2 and CPK20. Gutermuth T, et al. Plant Cell, 2013 Nov. PMID 24280384, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pollen tube growth regulation by free anions depends on the interaction between the anion channel SLAH3 and calcium-dependent protein kinases CPK2 and CPK20.
      Title: Pollen tube growth regulation by free anions depends on the interaction between the anion channel SLAH3 and calcium-dependent protein kinases CPK2 and CPK20.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111902.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin-domain protein kinase cdpk isoform 2
    NP_187677.1
    • calmodulin-domain protein kinase cdpk isoform 2 (CPK2); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Serine/threonine-protein kinase domain (InterPro:IPR002290), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992), EF-hand (InterPro:IPR018248), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), EF-HAND 2 (InterPro:IPR018249), Calcium-dependent protein kinase (InterPro:IPR020642), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: calcium dependent protein kinase 1 (TAIR:AT5G04870.1); Has 145304 Blast hits to 132515 proteins in 4265 species: Archae - 224; Bacteria - 17128; Metazoa - 53382; Fungi - 18632; Plants - 28672; Viruses - 609; Other Eukaryotes - 26657 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3331064..3334986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337889.1 → NP_001326044.1  calmodulin-domain protein kinase cdpk isoform 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38870
      UniProtKB/TrEMBL
      A0A178VDL8, A0A5S9XAY8
      Conserved Domains (3) summary
      PTZ00184
      Location:480 → 622
      PTZ00184; calmodulin; Provisional
      cd05117
      Location:185 → 443
      STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases
      NF033839
      Location:45 → 159
      PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form

    2. NM_111902.2 → NP_187677.1  calmodulin-domain protein kinase cdpk isoform 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187677.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38870
      UniProtKB/TrEMBL
      A0A178VDL8, A0A5S9XAY8
      Conserved Domains (3) summary
      PTZ00184
      Location:480 → 622
      PTZ00184; calmodulin; Provisional
      cd05117
      Location:185 → 443
      STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases
      NF033839
      Location:45 → 159
      PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38870.1

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