SFR6 sensitive to freezing 6 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SFR6
Official Full Name: sensitive to freezing 6
Primary source: TAIR:AT4G04920
Locus tag: AT4G04920
See related: Araport:AT4G04920
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtSFR6; IEN1; INSENSITIVE TO EXOGENOUS NAD+ 1; MED16; MEDIATOR 16; SENSITIVE TO FREEZING 6; T1J1.2; T1J1_2; YELLOW AND SENSITIVE TO IRON-DEFICIENCY 1; YID1
Summary: Encodes a nuclear targeted protein that plays a role in the CBF pathway -downstream of CBF translation. Mutants have impaired cold responses, reduced levels of cold induced RNA transcripts, are sensitive to osmotic stress. Required for expression of CBF-controlled cold-upregulated genes and some, but not all, other cold up-regulated genes. Required for recruitment of the Mediator complex and RNA polymerase II to CBF-controlled cold-responsive genes. Required for expression of some dark-upregulated genes.
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Genomic context

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See SFR6 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 16

Sequence:: Chromosome: 4; NC_003075.7 (2497598..2505554)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MEDIATOR16 orchestrates local and systemic responses to phosphate scarcity in Arabidopsis roots.
Title: MEDIATOR16 orchestrates local and systemic responses to phosphate scarcity in Arabidopsis roots.
Data show that mutations in MEDIATOR16 (MED16) reduce the number of misregulated genes in cobra (cob-6) mutants and suppress the phenotypes.
Title: Identification of MEDIATOR16 as the Arabidopsis COBRA suppressor MONGOOSE1.
MED16 regulates resistance to S. sclerotiorum by governing both jasmonic acid/ethylene-mediated and WRKY33-activated defense signaling in Arabidopsis. [MED16]
Title: The Arabidopsis Mediator Complex Subunit16 Is a Key Component of Basal Resistance against the Necrotrophic Fungal Pathogen Sclerotinia sclerotiorum.
MED16 is involved in the iron deficiency response, and modulates the iron uptake gene expression under iron limitation.
Title: Mediator subunit 16 functions in the regulation of iron uptake gene expression in Arabidopsis.
RNA polymerase II recruitment to CBF-responsive cold-regulated genes requires MED16, MED2, and MED14 subunits.
Title: The Arabidopsis mediator complex subunits MED16, MED14, and MED2 regulate mediator and RNA polymerase II recruitment to CBF-responsive cold-regulated genes.
YID1/MED16, together with MED25, regulate iron homeostasis by interacting with EIN3/EIL1 and regulating the expression of downstream genes.
Title: The Arabidopsis Mediator subunit MED16 regulates iron homeostasis by associating with EIN3/EIL1 through subunit MED25.
The Arabidopsis Mediator complex subunits MED14 and MED16 differentially regulate defense gene expression in plant immune responses.
Title: The Arabidopsis Mediator complex subunits MED14/SWP and MED16/SFR6/IEN1 differentially regulate defense gene expression in plant immune responses.
Mediator subunit16 (MED16) is an essential positive regulator of systemic acquired resistance (SAR).
Title: The Arabidopsis mediator complex subunit16 positively regulates salicylate-mediated systemic acquired resistance and jasmonate/ethylene-induced defense pathways.
SFR6 controls defence gene expression mediated by salicylic acid and jasmonate responsive pathways
Title: The Mediator subunit SFR6/MED16 controls defence gene expression mediated by salicylic acid and jasmonate responsive pathways.
SFR6 acts on the C-box binding factor pathway downstream of CBF translation.
Title: Identification of SFR6, a key component in cold acclimation acting post-translationally on CBF function.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MASC_STS12701 (e-PCR)
- UniSTS:258564

NM_001203747.1

Supported by ESTs:

NM_116730.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables transcription coregulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within abscisic acid-activated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within auxin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cold acclimation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within positive regulation of plant-type cell wall cellulose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of systemic acquired resistance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell wall pectin metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of ethylene-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of jasmonic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of long-day photoperiodism, flowering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of plant-type cell wall cellulose biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within trichome branching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trichome papilla formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: sensitive to freezing 6

NP_001190676.1

SENSITIVE TO FREEZING 6 (SFR6); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: cold acclimation, circadian regulation of gene expression, response to osmotic stress, regulation of long-day photoperiodism, flowering; LOCATED IN: nucleus; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 9 growth stages.

NP_192401.5

SENSITIVE TO FREEZING 6 (SFR6); Has 159 Blast hits to 81 proteins in 31 species: Archae - 0; Bacteria - 0; Metazoa - 10; Fungi - 5; Plants - 45; Viruses - 0; Other Eukaryotes - 99 (source: NCBI BLink).