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    Disease resistance protein (TIR-NBS-LRR class) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827692, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Disease resistance protein (TIR-NBS-LRR class)
    Primary source
    TAIR:AT4G19510
    Locus tag
    AT4G19510
    See related
    Araport:AT4G19510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F24J7.70; F24J7_70
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (10633619..10639036)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene VPS54 Neighboring gene nucleoside-triphosphatase/transmembrane receptor/nucleotide binding/ATP binding protein Neighboring gene disease resistance protein (TIR-NBS-LRR class) family Neighboring gene disease resistance protein (TIR-NBS-LRR class) family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    2. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001341344.1
    NM_001341351.1
    NM_118071.6
    NM_179079.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Disease resistance protein (TIR-NBS-LRR class)
    NP_193686.5
    • Disease resistance protein (TIR-NBS-LRR class); FUNCTIONS IN: transmembrane receptor activity, ATP binding; INVOLVED IN: signal transduction, apoptosis, defense response, innate immune response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT4G12010.1); Has 24495 Blast hits to 16844 proteins in 780 species: Archae - 22; Bacteria - 1657; Metazoa - 3405; Fungi - 143; Plants - 18330; Viruses - 4; Other Eukaryotes - 934 (source: NCBI BLink).
    NP_849410.1
    • Disease resistance protein (TIR-NBS-LRR class); FUNCTIONS IN: transmembrane receptor activity, ATP binding; INVOLVED IN: signal transduction, apoptosis, defense response, innate immune response; LOCATED IN: intrinsic to membrane, endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT4G12010.1); Has 17554 Blast hits to 12982 proteins in 513 species: Archae - 8; Bacteria - 748; Metazoa - 631; Fungi - 25; Plants - 15570; Viruses - 0; Other Eukaryotes - 572 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10633619..10639036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341345.1 → NP_001328451.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B4P3

    2. NM_001341346.1 → NP_001328448.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8B4Q1, F4JT80, O49469

    3. NM_001341347.1 → NP_001328447.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8B4Q1, F4JT80, O49469

    4. NM_001341348.1 → NP_001328450.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8B4Q1, F4JT80, O49469
      UniProtKB/TrEMBL
      A0A1P8B4P2

    5. NM_001341349.1 → NP_001328449.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8B4Q1, F4JT80, O49469

    6. NM_001341350.1 → NP_001328446.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8B4Q1, F4JT80, O49469

    7. NM_118071.6 → NP_193686.5  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193686.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8B4Q1, F4JT80, O49469
      Conserved Domains (4) summary
      PLN03210
      Location:57 → 1139
      PLN03210; Resistant to P. syringae 6; Provisional
      sd00033
      Location:682 → 704
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:633 → 658
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam01582
      Location:57 → 221
      TIR; TIR domain

    8. NM_001341351.1 → NP_001328445.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B4P0

    9. NM_179079.2 → NP_849410.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849410.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8B4Q1, F4JT80, O49469
      UniProtKB/TrEMBL
      F4JT81
      Conserved Domains (5) summary
      COG4886
      Location:594 → 820
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:610 → 627
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:702 → 745
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00931
      Location:198 → 442
      NB-ARC; NB-ARC domain
      pfam01582
      Location:17 → 181
      TIR; TIR domain

    10. NM_001341344.1 → NP_001328444.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B4P4
    Nucleotide Protein
    Heading Accession and Version

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