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    SNRK2.1 SNF1-related protein kinase 2.1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830760, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SNRK2.1
    Official Full Name
    SNF1-related protein kinase 2.1
    Primary source
    TAIR:AT5G08590
    Locus tag
    AT5G08590
    See related
    Araport:AT5G08590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS SERINE/THREONINE KINASE 2; ARABIDOPSIS SKP1-LIKE1; ASK2; MAH20.15; MAH20_15; SNF1-related protein kinase 2.1; SNRK2-1; SRK2G
    Summary
    Encodes a member of SNF1-related protein kinases (SnRK2) whose activity is activated by ionic (salt) and non-ionic (mannitol) osmotic stress. Similar to the calcium/calmodulin-dependent protein kinase subfamily and the SNF1 kinase subfamily.
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    Genomic context

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    See SNRK2.1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (2783168..2786113)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Transcription initiation Spt4-like protein Neighboring gene Pyruvate kinase family protein Neighboring gene Calcium-binding EF hand family protein Neighboring gene U3 ribonucleoprotein (Utp) family protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression, Purification, and Characterization of a Sucrose Nonfermenting 1-Related Protein Kinases 2 of Arabidopsis thaliana in E. coli-Based Cell-Free System. Zhang X, et al. Biomed Res Int, 2016. PMID 27999818, Free PMC Article
    2. Two putative protein kinases from Arabidopsis thaliana contain highly acidic domains. Park YS, et al. Plant Mol Biol, 1993 Jul. PMID 8393717
    3. Rapid Phosphoproteomic Effects of Abscisic Acid (ABA) on Wild-Type and ABA Receptor-Deficient A. thaliana Mutants. Minkoff BB, et al. Mol Cell Proteomics, 2015 May. PMID 25693798, Free PMC Article
    4. The SnRK2 kinases modulate miRNA accumulation in Arabidopsis. Yan J, et al. PLoS Genet, 2017 Apr. PMID 28419088, Free PMC Article
    5. FKF1 and GIGANTEA complex formation is required for day-length measurement in Arabidopsis. Sawa M, et al. Science, 2007 Oct 12. PMID 17872410, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Further analysis revealed that the steady state level of HYL1 protein in plants under osmotic stress is dependent on the SnRK2 kinases. Additionally, our results suggest that the SnRK2 kinases physically associate with the miRNA processing components SE and HYL1 and can phosphorylate these proteins in vitro.
      Title: The SnRK2 kinases modulate miRNA accumulation in Arabidopsis.
    2. The recombinant SnRK2.1 was produced in large-scale and the autophosphorylation activity of purified SnRK2.1 was characterized, allowing for further biochemical and substrate binding analysis in sulfur signaling.
      Title: Expression, Purification, and Characterization of a Sucrose Nonfermenting 1-Related Protein Kinases 2 of Arabidopsis thaliana in E. coli-Based Cell-Free System.
    3. Abscisic acid receptor PYL2 deletion changes the phosphorylation pattern of SnRK2 kinase subset in response to abscisic acid signaling.
      Title: Rapid Phosphoproteomic Effects of Abscisic Acid (ABA) on Wild-Type and ABA Receptor-Deficient A. thaliana Mutants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_120946.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    SNF1-related protein kinase 2.1
    NP_196476.1
    • SNF1-related protein kinase 2.1 (SNRK2.1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Serine/threonine-protein kinase-like, plant (InterPro:IPR015740); BEST Arabidopsis thaliana protein match is: SNF1-related protein kinase 2.5 (TAIR:AT5G63650.1); Has 111442 Blast hits to 109710 proteins in 3187 species: Archae - 120; Bacteria - 13026; Metazoa - 41713; Fungi - 12000; Plants - 24961; Viruses - 485; Other Eukaryotes - 19137 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2783168..2786113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343022.1 → NP_001331206.1  SNF1-related protein kinase 2.1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BD58

    2. NM_120946.5 → NP_196476.1  SNF1-related protein kinase 2.1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196476.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P43292, Q24JK3, Q9FNM9
      UniProtKB/TrEMBL
      A0A178UA36, A0A5S9Y3D4, A0A5S9YHE3
      Conserved Domains (1) summary
      cd14662
      Location:3 → 259
      STKc_SnRK2; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43292.2

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