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    lactate/malate dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835945, updated on 18-Sep-2024

    Summary

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    Official Full Name
    lactate/malate dehydrogenase family protein
    Primary source
    TAIR:AT5G58330
    Locus tag
    AT5G58330
    See related
    Araport:AT5G58330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MCK7.20; MCK7_20; NADP-dependent Malate Dehydrogenase; NADP-MDH
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (23579722..23582395, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene methyl esterase 18 Neighboring gene ncRNA Neighboring gene Kinase interacting (KIP1-like) family protein Neighboring gene myb-like HTH transcriptional regulator family protein Neighboring gene with no lysine (K) kinase 4 Neighboring gene ovate family protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High light response of the thylakoid proteome in arabidopsis wild type and the ascorbate-deficient mutant vtc2-2. A comparative proteomics study. Giacomelli L, et al. Plant Physiol, 2006 Jun. PMID 16648217, Free PMC Article
    2. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804
    3. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
    4. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
    5. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125218.4
    NM_180883.3
    NM_203229.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-malate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-malate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in malate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to redox state IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in plastid HDA PubMed 
    located_in thylakoid HDA PubMed 

    General protein information

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    Preferred Names
    lactate/malate dehydrogenase family protein
    NP_568875.2
    • lactate/malate dehydrogenase family protein; FUNCTIONS IN: oxidoreductase activity, malate dehydrogenase activity, binding, catalytic activity, malate dehydrogenase (NADP+) activity; INVOLVED IN: oxidation reduction, malate metabolic process, carbohydrate metabolic process, metabolic process; LOCATED IN: thylakoid, mitochondrion, apoplast, chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Malate dehydrogenase, NAD/NADP (InterPro:IPR010945), Lactate/malate dehydrogenase, C-terminal (InterPro:IPR022383), Malate dehydrogenase, NADP-dependent, plants (InterPro:IPR011273), NAD(P)-binding domain (InterPro:IPR016040), Lactate/malate dehydrogenase, N-terminal (InterPro:IPR001236), Malate dehydrogenase, active site (InterPro:IPR001252), Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (InterPro:IPR015955); BEST Arabidopsis thaliana protein match is: Lactate/malate dehydrogenase family protein (TAIR:AT5G56720.1); Has 9958 Blast hits to 9954 proteins in 2609 species: Archae - 125; Bacteria - 6277; Metazoa - 781; Fungi - 166; Plants - 567; Viruses - 0; Other Eukaryotes - 2042 (source: NCBI BLink).
    NP_851214.1
    • lactate/malate dehydrogenase family protein; FUNCTIONS IN: oxidoreductase activity, binding, malate dehydrogenase activity, catalytic activity, malate dehydrogenase (NADP+) activity; INVOLVED IN: oxidation reduction, malate metabolic process, carbohydrate metabolic process, metabolic process; LOCATED IN: in 6 components; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Malate dehydrogenase, NAD/NADP (InterPro:IPR010945), Lactate/malate dehydrogenase, C-terminal (InterPro:IPR022383), Malate dehydrogenase, NADP-dependent, plants (InterPro:IPR011273), NAD(P)-binding domain (InterPro:IPR016040), Lactate/malate dehydrogenase, N-terminal (InterPro:IPR001236), Malate dehydrogenase, active site (InterPro:IPR001252), Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (InterPro:IPR015955); BEST Arabidopsis thaliana protein match is: Lactate/malate dehydrogenase family protein (TAIR:AT5G56720.1); Has 10000 Blast hits to 9996 proteins in 2628 species: Archae - 125; Bacteria - 6319; Metazoa - 780; Fungi - 166; Plants - 568; Viruses - 0; Other Eukaryotes - 2042 (source: NCBI BLink).
    NP_974958.1
    • lactate/malate dehydrogenase family protein; FUNCTIONS IN: in 6 functions; INVOLVED IN: in 6 processes; LOCATED IN: thylakoid, mitochondrion, apoplast, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Malate dehydrogenase, NAD/NADP (InterPro:IPR010945), Lactate/malate dehydrogenase, C-terminal (InterPro:IPR022383), Malate dehydrogenase, NADP-dependent, plants (InterPro:IPR011273), NAD(P)-binding domain (InterPro:IPR016040), L-lactate/malate dehydrogenase (InterPro:IPR001557), Lactate/malate dehydrogenase, N-terminal (InterPro:IPR001236), Malate dehydrogenase, active site (InterPro:IPR001252), Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (InterPro:IPR015955); BEST Arabidopsis thaliana protein match is: Lactate/malate dehydrogenase family protein (TAIR:AT5G56720.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23579722..23582395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125218.4 → NP_568875.2  lactate/malate dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568875.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9YF37, A0A654GCA1, A0A7G2FI12
      Conserved Domains (1) summary
      PLN00112
      Location:1 → 442
      PLN00112; malate dehydrogenase (NADP); Provisional

    2. NM_180883.3 → NP_851214.1  lactate/malate dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851214.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H1E2, Q8LCQ9, Q8VXZ3, Q9LVL7
      UniProtKB/TrEMBL
      A0A7G2FJ35
      Conserved Domains (1) summary
      PLN00112
      Location:1 → 443
      PLN00112; malate dehydrogenase (NADP); Provisional

    3. NM_203229.2 → NP_974958.1  lactate/malate dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974958.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UKK6, F4KEX3
      Conserved Domains (2) summary
      TIGR01759
      Location:1 → 310
      MalateDH-SF1; malate dehydrogenase
      cd01338
      Location:1 → 312
      MDH_choloroplast_like; Chloroplast-like malate dehydrogenases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H1E2.1

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