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    AGD1 ARF-GAP domain 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836319, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AGD1
    Official Full Name
    ARF-GAP domain 1
    Primary source
    TAIR:AT5G61980
    Locus tag
    AT5G61980
    See related
    Araport:AT5G61980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARF-GAP domain 1; K22G18.9; K22G18_9
    Summary
    A member of ARF GAP domain (AGD), A thaliana has 15 members, grouped into four classes. AGD1 belongs to the class 1, together with AGD2, AGD3 and AGD4. Not expressed in hypocotyls and cotyledons.
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    Genomic context

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    See AGD1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    19
    Sequence:
    Chromosome: 5; NC_003076.8 (24894053..24899973)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene MEI2-like protein 1 Neighboring gene signal recognition particle-related / SRP-like protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletion analysis of AGD1 reveals domains crucial for plasma membrane recruitment and function in root hair polarity. Yoo CM, et al. J Cell Sci, 2018 Jan 29. PMID 28646092
    2. AGD1, a class 1 ARF-GAP, acts in common signaling pathways with phosphoinositide metabolism and the actin cytoskeleton in controlling Arabidopsis root hair polarity. Yoo CM, et al. Plant J, 2012 Mar. PMID 22098134
    3. A class I ADP-ribosylation factor GTPase-activating protein is critical for maintaining directional root hair growth in Arabidopsis. Yoo CM, et al. Plant Physiol, 2008 Aug. PMID 18539780, Free PMC Article
    4. SCARFACE encodes an ARF-GAP that is required for normal auxin efflux and vein patterning in Arabidopsis. Sieburth LE, et al. Plant Cell, 2006 Jun. PMID 16698946, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. differential recruitment of AGD1 to specific plasma membrane domains is an essential component of the membrane trafficking machinery that facilitates root hair developmental phase transitions and responses to changes in the root microenvironment.
      Title: Deletion analysis of AGD1 reveals domains crucial for plasma membrane recruitment and function in root hair polarity.
    2. AGD1 functions in converging signaling pathways with phosphoinositides and actin in controlling root hair development.
      Title: AGD1, a class 1 ARF-GAP, acts in common signaling pathways with phosphoinositide metabolism and the actin cytoskeleton in controlling Arabidopsis root hair polarity.
    3. AGD1, a class I ADP ribosylation factor GTPase-activating protein, is important for maintaining straight growth in Arabidopsis root hairs.
      Title: A class I ADP-ribosylation factor GTPase-activating protein is critical for maintaining directional root hair growth in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_125591.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair cell tip growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in root hair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ARF-GAP domain 1
    NP_201004.2
    • ARF-GAP domain 1 (AGD1); FUNCTIONS IN: ARF GTPase activator activity, zinc ion binding; INVOLVED IN: cytoskeleton organization; LOCATED IN: endocytic vesicle; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Arf GTPase activating protein (InterPro:IPR001164), Pleckstrin homology-type (InterPro:IPR011993), Ankyrin repeat-containing domain (InterPro:IPR020683), BAR (InterPro:IPR004148), Pleckstrin homology (InterPro:IPR001849), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: ARF GTPase-activating protein (TAIR:AT5G13300.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24894053..24899973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125591.3 → NP_201004.2  ARF-GAP domain 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201004.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FIT8
      UniProtKB/TrEMBL
      A0A178ULW4, A0A7G2FI39
      Conserved Domains (5) summary
      cd07606
      Location:15 → 215
      BAR_SFC_plant; The Bin/Amphiphysin/Rvs (BAR) domain of the plant protein SCARFACE (SFC)
      cd13250
      Location:291 → 429
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:740 → 766
      ANK; ANK repeat [structural motif]
      cd08204
      Location:501 → 630
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
      pfam12796
      Location:729 → 799
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FIT8.2

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