HOG1 S-adenosyl-L-homocysteine hydrolase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HOG1
Official Full Name: S-adenosyl-L-homocysteine hydrolase
Primary source: TAIR:AT4G13940
Locus tag: AT4G13940
See related: Araport:AT4G13940
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATSAHH1; DL3010W; EMB1395; EMBRYO DEFECTIVE 1395; FCAALL.35; HOMOLOGY-DEPENDENT GENE SILENCING 1; MATERNAL EFFECT EMBRYO ARREST 58; MEE58; S-ADENOSYL-L-HOMOCYSTEIN HYDROLASE 1; S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE; SAH1; SAHH1
Summary: Encodes a S-adenosyl-L-homocysteine hydrolase required for DNA methylation-dependent gene silencing.
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Genomic context

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See HOG1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 3

Sequence:: Chromosome: 4; NC_003075.7 (8054673..8057181)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SAHH1 plays a critical role in methyl homeostasis, and its deficiency is a major contributing factor to the change of global gene expression, metabolic pathways and activation of transposable elements in the sahh1 mutant.
Title: Transcriptome profiling and methyl homeostasis of an Arabidopsis mutant deficient in S-adenosylhomocysteine hydrolase1 (SAHH1).
The nuclear targeting of ADK1 and SAHH1 is mediated by their interaction with cap MT.
Title: Nuclear targeting of methyl-recycling enzymes in Arabidopsis thaliana is mediated by specific protein interactions.
HOG1 has high affinity cytokinin binding activity. Overexpression led to early flowering with a significantly reduced plant biomass and number of leaves.
Title: Arabidopsis HOG1 gene and its petunia homolog PETCBP act as key regulators of yield parameters.
A histone methylation-dependent DNA methylation pathway is uniquely impaired by deficiency in adenosylhomocysteinase.
Title: A histone methylation-dependent DNA methylation pathway is uniquely impaired by deficiency in Arabidopsis S-adenosylhomocysteine hydrolase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001036550.1

Supported by ESTs:

NM_001036551.1

Supported by ESTs:

NM_001084918.1

Supported by ESTs:

NM_117468.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables adenosylhomocysteinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables copper ion binding	HDA more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA methylation-dependent constitutive heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	NAS Non-traceable Author Statement more info
acts_upstream_of_or_within post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed
located_in vacuole	HDA more info	PubMed

General protein information

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Preferred Names: S-adenosyl-L-homocysteine hydrolase

NP_001031627.1

HOMOLOGY-DEPENDENT GENE SILENCING 1 (HOG1); FUNCTIONS IN: adenosylhomocysteinase activity, copper ion binding; INVOLVED IN: methylation-dependent chromatin silencing, one-carbon metabolic process, posttranscriptional gene silencing, embryo development ending in seed dormancy; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 35 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: S-adenosyl-L-homocysteine hydrolase (InterPro:IPR000043), S-adenosyl-L-homocysteine hydrolase, conserved site (InterPro:IPR020082), S-adenosyl-L-homocysteine hydrolase, NAD binding (InterPro:IPR015878); BEST Arabidopsis thaliana protein match is: S-adenosyl-l-homocysteine (SAH) hydrolase 2 (TAIR:AT3G23810.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_001031628.1

HOMOLOGY-DEPENDENT GENE SILENCING 1 (HOG1); FUNCTIONS IN: adenosylhomocysteinase activity, copper ion binding; INVOLVED IN: methylation-dependent chromatin silencing, one-carbon metabolic process, posttranscriptional gene silencing, embryo development ending in seed dormancy; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 35 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: S-adenosyl-L-homocysteine hydrolase (InterPro:IPR000043), S-adenosyl-L-homocysteine hydrolase, conserved site (InterPro:IPR020082), S-adenosyl-L-homocysteine hydrolase, NAD binding (InterPro:IPR015878); BEST Arabidopsis thaliana protein match is: S-adenosyl-l-homocysteine (SAH) hydrolase 2 (TAIR:AT3G23810.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_001078387.1

HOMOLOGY-DEPENDENT GENE SILENCING 1 (HOG1); FUNCTIONS IN: adenosylhomocysteinase activity; INVOLVED IN: methylation-dependent chromatin silencing, one-carbon metabolic process, posttranscriptional gene silencing, embryo development ending in seed dormancy; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 34 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: S-adenosyl-L-homocysteine hydrolase (InterPro:IPR000043), S-adenosyl-L-homocysteine hydrolase, conserved site (InterPro:IPR020082), NAD(P)-binding domain (InterPro:IPR016040), S-adenosyl-L-homocysteine hydrolase, NAD binding (InterPro:IPR015878); BEST Arabidopsis thaliana protein match is: S-adenosyl-l-homocysteine (SAH) hydrolase 2 (TAIR:AT3G23810.1); Has 6788 Blast hits to 6786 proteins in 1444 species: Archae - 223; Bacteria - 2243; Metazoa - 514; Fungi - 135; Plants - 203; Viruses - 0; Other Eukaryotes - 3470 (source: NCBI BLink).

NP_193130.1

MATERNAL EFFECT EMBRYO ARREST 58 (MEE58); FUNCTIONS IN: adenosylhomocysteinase activity, copper ion binding; INVOLVED IN: methylation-dependent chromatin silencing, one-carbon metabolic process, posttranscriptional gene silencing, embryo development ending in seed dormancy; LOCATED IN: plasma membrane, vacuole, membrane; EXPRESSED IN: 36 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: S-adenosyl-L-homocysteine hydrolase, conserved site (InterPro:IPR020082), S-adenosyl-L-homocysteine hydrolase (InterPro:IPR000043), S-adenosyl-L-homocysteine hydrolase, NAD binding (InterPro:IPR015878); BEST Arabidopsis thaliana protein match is: S-adenosyl-l-homocysteine (SAH) hydrolase 2 (TAIR:AT3G23810.1); Has 7964 Blast hits to 7958 proteins in 1477 species: Archae - 229; Bacteria - 2334; Metazoa - 639; Fungi - 145; Plants - 247; Viruses - 0; Other Eukaryotes - 4370 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

8054673..8057181

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117468.3 → NP_193130.1 S-adenosyl-L-homocysteine hydrolase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_193130.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O23255, O81847, Q8LE20

UniProtKB/TrEMBL

A0A178UZR5, A0A5S9XS27, Q5D6C3, Q5D6C4, Q5D6C5

Conserved Domains (1) summary

PLN02494
Location:9 → 485

PLN02494; adenosylhomocysteinase
NM_001084918.1 → NP_001078387.1 S-adenosyl-L-homocysteine hydrolase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078387.1

Status: REVIEWED

UniProtKB/TrEMBL

A8MQP1, B9DG03

Conserved Domains (1) summary

cl21454
Location:13 → 308

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001036551.1 → NP_001031628.1 S-adenosyl-L-homocysteine hydrolase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031628.1

Status: REVIEWED

UniProtKB/TrEMBL

F4JTV4, Q5D6C3, Q5D6C4, Q5D6C5

Conserved Domains (2) summary

PLN02494
Location:9 → 440

PLN02494; adenosylhomocysteinase

pfam05221
Location:13 → 439

AdoHcyase; S-adenosyl-L-homocysteine hydrolase
NM_001036550.1 → NP_001031627.1 S-adenosyl-L-homocysteine hydrolase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031627.1

Status: REVIEWED

UniProtKB/TrEMBL

F4JTV5

Conserved Domains (1) summary

cl21454
Location:2 → 363

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins