BRIZ1 zinc finger (ubiquitin-hydrolase) domain-containing protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BRIZ1
Official Full Name: zinc finger (ubiquitin-hydrolase) domain-containing protein
Primary source: TAIR:AT2G42160
Locus tag: AT2G42160
See related: Araport:AT2G42160
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BRAP2 RING ZnF UBP domain-containing protein 1; T24P15.7; T24P15_7
Summary: Encodes a RING domain containing protein BRIZ1. BRIZ1 (At2g42160) and BRIZ2 (At2g26000) proteins form a heteromeric E3 ligase complex required for seed germination and post-germination growth.
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Genomic context

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See BRIZ1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 11

Sequence:: Chromosome: 2; NC_003071.7 (17574641..17577495, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001336951.1

Supported by ESTs:

NM_001336952.1

Supported by ESTs:

NM_129779.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of seed germination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
part_of ubiquitin ligase complex	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: zinc finger (ubiquitin-hydrolase) domain-containing protein

NP_181746.2

BRAP2 RING ZnF UBP domain-containing protein 1 (BRIZ1); FUNCTIONS IN: catalytic activity, zinc ion binding; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: BRCA1-associated 2 (InterPro:IPR011422), Zinc finger, UBP-type (InterPro:IPR001607), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: zinc finger (C3HC4-type RING finger) family protein (TAIR:AT2G26000.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

17574641..17577495 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129779.4 → NP_181746.2 zinc finger (ubiquitin-hydrolase) domain-containing protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181746.2

Status: REVIEWED

UniProtKB/Swiss-Prot

E5KGE0, O48524, Q8GWY2

UniProtKB/TrEMBL

A0A654F6E7

Conserved Domains (4) summary

cd16457
Location:172 → 214

RING-H2_BRAP2; RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins

pfam02148
Location:225 → 286

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

pfam07576
Location:67 → 159

BRAP2; BRCA1-associated protein 2

cl21509
Location:354 → 463

ApoLp-III_like; Apolipophorin-III and similar insect proteins
NM_001336951.1 → NP_001323960.1 zinc finger (ubiquitin-hydrolase) domain-containing protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VV25, A0A1P8AYK4
NM_001336952.1 → NP_001323961.1 zinc finger (ubiquitin-hydrolase) domain-containing protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VV25, A0A1P8AYR4