ATHB-15 Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ATHB-15
Official Full Name: Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein
Primary source: TAIR:AT1G52150
Locus tag: AT1G52150
See related: Araport:AT1G52150
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATHB15; CNA; CORONA; F5F19.21; F5F19_21; ICU4; INCURVATA 4
Summary: Member of the class III HD-ZIP protein family. Contains homeodomain and leucine zipper domain. Critical for vascular development and negatively regulates vascular cell differentiation.
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Genomic context

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See ATHB-15 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 18

Sequence:: Chromosome: 1; NC_003070.9 (19409688..19414764, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The branching ovules of the mutant resemble those of some fossil gymnosperms, implicating BEL1 and HD-ZIPIII genes as players in the evolution of the unbranched ovule form in extant angiosperms.
Title: CORONA, PHABULOSA and PHAVOLUTA collaborate with BELL1 to confine WUSCHEL expression to the nucellus in Arabidopsis ovules.
Transgenic over-expression of a mutant form of AtHB15 that is resistant to miR165-mediated cleavage reversed the stp-2d mutant phenotype to wild-type, indicating that AtHB15 represses secondary wall development in pith.
Title: Activation of miR165b represses AtHB15 expression and induces pith secondary wall development in Arabidopsis.
stem cell specification pathway is normally repressed by the activity of the HD-zip III transcription factors PHABULOSA (PHB), PHAVOLUTA (PHV) and CORONA (CNA).
Title: A WUSCHEL-Independent Stem Cell Specification Pathway Is Repressed by PHB, PHV and CNA in Arabidopsis.
An amino acid substitution in the class III HD-ZIP transcription factor ATHB15 enhanced shoot organogenesis.
Title: Arabidopsis shoot organogenesis is enhanced by an amino acid change in the ATHB15 transcription factor.
Alteration of the shoot radial pattern in Arabidiopsis thaliana by a gain-of-function allele of the class III HD-Zip gene INCURVATA4 is reported.
Title: Alteration of the shoot radial pattern in Arabidopsis thaliana by a gain-of-function allele of the class III HD-Zip gene INCURVATA4.
Regulation of ATHB15 in a mutatnt A. thaliana that affects vascular cell differentiation and inflorescence elongation.
Title: microRNA-directed cleavage of ATHB15 mRNA regulates vascular development in Arabidopsis inflorescence stems.
Class III HD-Zip AND KANADI genes required for root development [ATHB15]
Title: Roles for Class III HD-Zip and KANADI genes in Arabidopsis root development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001084233.2

Supported by ESTs:

NM_104096.3

Supported by ESTs:

NM_179464.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within determination of bilateral symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of dorsal identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within integument development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within leaf morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meristem initiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meristem maintenance	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within phloem or xylem histogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of meristem growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein

NP_001077702.1

ATHB-15; CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), MEKHLA (InterPro:IPR013978), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeobox gene 8 (TAIR:AT4G32880.1); Has 3126 Blast hits to 3055 proteins in 249 species: Archae - 0; Bacteria - 0; Metazoa - 767; Fungi - 91; Plants - 2233; Viruses - 0; Other Eukaryotes - 35 (source: NCBI BLink).

NP_175627.1

ATHB-15; CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), MEKHLA (InterPro:IPR013978), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeobox gene 8 (TAIR:AT4G32880.1); Has 3146 Blast hits to 3075 proteins in 258 species: Archae - 0; Bacteria - 18; Metazoa - 766; Fungi - 90; Plants - 2237; Viruses - 0; Other Eukaryotes - 35 (source: NCBI BLink).

NP_849795.1

ATHB-15; CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), MEKHLA (InterPro:IPR013978), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeobox gene 8 (TAIR:AT4G32880.1); Has 3139 Blast hits to 3068 proteins in 257 species: Archae - 0; Bacteria - 18; Metazoa - 766; Fungi - 90; Plants - 2230; Viruses - 0; Other Eukaryotes - 35 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

19409688..19414764 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104096.3 → NP_175627.1 Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_175627.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5EE12, Q9FWZ0, Q9ZU11

UniProtKB/TrEMBL

A0A5S9WR09, A0A654EHN9

Conserved Domains (4) summary

cd08875
Location:155 → 371

START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins

cd14686
Location:69 → 108

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

pfam00046
Location:17 → 75

Homeobox; Homeobox domain

pfam08670
Location:692 → 835

MEKHLA; MEKHLA domain
NM_001084233.2 → NP_001077702.1 Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001077702.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9WR09, F4IBA6

Conserved Domains (4) summary

cd08875
Location:155 → 371

START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins

cd14686
Location:69 → 108

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

pfam00046
Location:17 → 74

Homeobox; Homeobox domain

pfam08670
Location:692 → 788

MEKHLA; MEKHLA domain
NM_179464.1 → NP_849795.1 Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849795.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9WR09, B3H4G8

Conserved Domains (4) summary

cd08875
Location:155 → 371

START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins

cd14686
Location:69 → 108

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

pfam00046
Location:17 → 74

Homeobox; Homeobox domain

pfam08670
Location:693 → 832

MEKHLA; MEKHLA domain