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    PIN6 Auxin efflux carrier family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844046, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PIN6
    Official Full Name
    Auxin efflux carrier family protein
    Primary source
    TAIR:AT1G77110
    Locus tag
    AT1G77110
    See related
    Araport:AT1G77110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22K20.18; F22K20_18; PIN-FORMED 6
    Summary
    Rate-limiting factor in saturable efflux of auxins. PINs are directly involved of in catalyzing cellular auxin efflux.
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    Genomic context

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    See PIN6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (28970714..28974805)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene peroxidase superfamily protein Neighboring gene alcohol dehydrogenase 1 Neighboring gene Uncharacterized protein family UPF0090 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of auxin transporter PIN6 plasma membrane targeting reveals a function for PIN6 in plant bolting. Ditengou FA, et al. New Phytol, 2018 Mar. PMID 29218850
    2. PIN6 auxin transporter at endoplasmic reticulum and plasma membrane mediates auxin homeostasis and organogenesis in Arabidopsis. Simon S, et al. New Phytol, 2016 Jul. PMID 27240710
    3. The promoter of the Arabidopsis PIN6 auxin transporter enabled strong expression in the vasculature of roots, leaves, floral stems and reproductive organs. Nisar N, et al. Plant Signal Behav, 2014. PMID 24487186, Free PMC Article
    4. Role of the Arabidopsis PIN6 auxin transporter in auxin homeostasis and auxin-mediated development. Cazzonelli CI, et al. PLoS One, 2013. PMID 23922907, Free PMC Article
    5. PIN6 is required for nectary auxin response and short stamen development. Bender RL, et al. Plant J, 2013 Jun. PMID 23551385

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PIN6 subcellular localization is under the control of developmental signals acting on tissue-specific determinants controlling PIN6-expression levels and PIN6 phosphorylation.
      Title: Characterization of auxin transporter PIN6 plasma membrane targeting reveals a function for PIN6 in plant bolting.
    2. PIN6 role in the control of auxin transport and homeostasis during auxin-mediated development including the lateral and adventitious root organogenesis
      Title: PIN6 auxin transporter at endoplasmic reticulum and plasma membrane mediates auxin homeostasis and organogenesis in Arabidopsis.
    3. preferentially expressed in the vasculature of the primary root, cotyledons, cauline leaves, floral stem, sepals, main transmitting tract of reproductive silique
      Title: The promoter of the Arabidopsis PIN6 auxin transporter enabled strong expression in the vasculature of roots, leaves, floral stems and reproductive organs.
    4. Data indicate that PIN6 regulates auxin homeostasis during plant development.
      Title: Role of the Arabidopsis PIN6 auxin transporter in auxin homeostasis and auxin-mediated development.
    5. PIN6 is required for proper auxin response and nectary function in Arabidopsis.
      Title: PIN6 is required for nectary auxin response and short stamen development.
    6. Expression of PIN6 is positively correlated with total nectar production in Arabidopsis and is required for the proper development of short stamens.
      Title: PIN6 is required for nectary auxin response and short stamen development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_106361.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables auxin efflux transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in auxin export across the plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within basipetal auxin transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in basipetal auxin transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of ethylene-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ethylene-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of lateral root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of lateral root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in root hair elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Auxin efflux carrier family protein
    NP_177836.1
    • PIN-FORMED 6 (PIN6); FUNCTIONS IN: auxin:hydrogen symporter activity, transporter activity; INVOLVED IN: auxin polar transport; LOCATED IN: plasma membrane; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Auxin efflux carrier, subgroup (InterPro:IPR014024), Auxin efflux carrier (InterPro:IPR004776); BEST Arabidopsis thaliana protein match is: Auxin efflux carrier family protein (TAIR:AT2G01420.1); Has 1564 Blast hits to 1346 proteins in 434 species: Archae - 34; Bacteria - 892; Metazoa - 10; Fungi - 0; Plants - 502; Viruses - 0; Other Eukaryotes - 126 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28970714..28974805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001334766.1 → NP_001323018.1  Auxin efflux carrier family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AVV0, A0A5S9WV38, A0A654EPY2
      Conserved Domains (1) summary
      pfam03547
      Location:9 → 191
      Mem_trans; Membrane transport protein

    2. NM_106361.4 → NP_177836.1  Auxin efflux carrier family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177836.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49294, Q9SQH6
      UniProtKB/TrEMBL
      A0A178W8W8, A0A7G2E530
      Conserved Domains (1) summary
      pfam03547
      Location:409 → 565
      Mem_trans; Membrane transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SQH6.2

    Gene LinkOut

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