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    MAF1 K-box region and MADS-box transcription factor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844042, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MAF1
    Official Full Name
    K-box region and MADS-box transcription factor family protein
    Primary source
    TAIR:AT1G77080
    Locus tag
    AT1G77080
    See related
    Araport:AT1G77080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AGAMOUS-like 27; AGL27; FLM; FLOWERING LOCUS M; MADS AFFECTING FLOWERING 1
    Summary
    MADS domain protein - flowering regulator that is closely related to FLC. Deletion of this locus in Nd ecotype is correlated with earlier flowering in short days suggesting function as a negative regulator of flowering.
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    Genomic context

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    See MAF1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (28955483..28960234)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene tRNA-Gln Neighboring gene putative DEAD-box ATP-dependent RNA helicase 29 Neighboring gene Phosphoenolpyruvate carboxylase family protein Neighboring gene thylakoid lumenal protein (Mog1/PsbP/DUF1795-like photosystem II reaction center PsbP family protein) Neighboring gene Defensin-like (DEFL) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural variation at FLM splicing has pleiotropic effects modulating ecological strategies in Arabidopsis thaliana. Hanemian M, et al. Nat Commun, 2020 Aug 18. PMID 32811829, Free PMC Article
    2. Regulation of flowering in Arabidopsis by an FLC homologue. Ratcliffe OJ, et al. Plant Physiol, 2001 May. PMID 11351076, Free PMC Article
    3. Quantitative trait locus mapping and DNA array hybridization identify an FLM deletion as a cause for natural flowering-time variation. Werner JD, et al. Proc Natl Acad Sci U S A, 2005 Feb 15. PMID 15695584, Free PMC Article
    4. Temperature-dependent regulation of flowering by antagonistic FLM variants. Posé D, et al. Nature, 2013 Nov 21. PMID 24067612
    5. Modulation of Ambient Temperature-Dependent Flowering in Arabidopsis thaliana by Natural Variation of FLOWERING LOCUS M. Lutz U, et al. PLoS Genet, 2015 Oct. PMID 26492483, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impact on Arabidopsis growth and stress resistance of depleting the Maf1 repressor of RNA polymerase III.
      Title: Impact on Arabidopsis growth and stress resistance of depleting the Maf1 repressor of RNA polymerase III.
    2. Regulation of flowering transition by alternative splicing: the role of the U2 auxiliary factor.
      Title: Regulation of flowering transition by alternative splicing: the role of the U2 auxiliary factor.
    3. Natural variation at FLM splicing has pleiotropic effects modulating ecological strategies in Arabidopsis thaliana.
      Title: Natural variation at FLM splicing has pleiotropic effects modulating ecological strategies in Arabidopsis thaliana.
    4. repressor activity is regulated by the TOR signaling pathway and is critical for cell survival during environmental stresses
      Title: Characterization of Maf1 in Arabidopsis: function under stress conditions and regulation by the TOR signaling pathway.
    5. The data support the role of FLM-beta as a flower repressor and provide evidence that a contribution of FLM-delta to the regulation of flowering time in wild-type Arabidopsis thaliana seems unlikely.
      Title: Contribution of major FLM isoforms to temperature-dependent flowering in Arabidopsis thaliana.
    6. This study's findings suggest a model in which the loss of the floral repressor FLM occurs through mRNA degradation in response to elevated temperatures, signifying a role for alternative splicing coupled with nonsense-mediated mRNA decay (AS-NMD) in conferring environmental responses in plants.
      Title: Nonsense-mediated mRNA decay modulates FLM-dependent thermosensory flowering response in Arabidopsis.
    7. we identify insertion polymorphisms in the first intron of FLM as causative for accelerated flowering in many natural A. thaliana accessions, especially in cool (15 degrees C) temperatures
      Title: Modulation of Ambient Temperature-Dependent Flowering in Arabidopsis thaliana by Natural Variation of FLOWERING LOCUS M.
    8. FLM and MAF2 repress flowering in parallel at low temperature.
      Title: MAF2 Is Regulated by Temperature-Dependent Splicing and Represses Flowering at Low Temperatures in Parallel with FLM.
    9. SVP-FLM-beta complex is predominately formed at low temperatures and prevents precocious flowering; by contrast, the competing SVP-FLM-delta complex is impaired in DNA binding and acts as a dominant-negative activator of flowering at higher temperatures
      Title: Temperature-dependent regulation of flowering by antagonistic FLM variants.
    10. Control of SVP-FLM-beta repressor complex abundance via transcriptional and splicing regulation of FLM and posttranslational regulation of SVP protein stability provides an efficient, rapid mechanism for plants to respond to ambient temperature changes.
      Title: Regulation of temperature-responsive flowering by MADS-box transcription factor repressors.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001334759.1
    NM_001334760.1
    NM_001334761.1
    NM_001334765.1
    NM_106358.4
    NM_180648.3
    NM_180649.4
    NM_202431.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    K-box region and MADS-box transcription factor family protein
    NP_177833.3
    • MADS AFFECTING FLOWERING 1 (MAF1); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: photoperiodism, flowering, negative regulation of flower development, regulation of transcription, DNA-dependent, regulation of flower development; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT5G65060.1); Has 6797 Blast hits to 6793 proteins in 852 species: Archae - 0; Bacteria - 0; Metazoa - 628; Fungi - 302; Plants - 5793; Viruses - 0; Other Eukaryotes - 74 (source: NCBI BLink).
    NP_850979.1
    • MADS AFFECTING FLOWERING 1 (MAF1); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: photoperiodism, flowering, negative regulation of flower development, regulation of transcription, DNA-dependent, regulation of flower development; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT5G65060.1); Has 6588 Blast hits to 6585 proteins in 820 species: Archae - 0; Bacteria - 0; Metazoa - 618; Fungi - 300; Plants - 5597; Viruses - 0; Other Eukaryotes - 73 (source: NCBI BLink).
    NP_850980.2
    • MADS AFFECTING FLOWERING 1 (MAF1); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: photoperiodism, flowering, negative regulation of flower development, regulation of transcription, DNA-dependent, regulation of flower development; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT5G65060.1); Has 576 Blast hits to 572 proteins in 45 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 576; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).
    NP_974160.2
    • K-box region and MADS-box transcription factor family protein; FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: photoperiodism, flowering, negative regulation of flower development, regulation of transcription, DNA-dependent, regulation of flower development; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT5G65060.1); Has 6885 Blast hits to 6879 proteins in 856 species: Archae - 0; Bacteria - 1; Metazoa - 618; Fungi - 302; Plants - 5888; Viruses - 0; Other Eukaryotes - 76 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28955483..28960234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001334762.1 → NP_001321575.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARC3

    2. NM_001334763.1 → NP_001321576.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARB5

    3. NM_001334764.1 → NP_001321570.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARA3, A0A5S9WV19

    4. NM_106358.4 → NP_177833.3  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177833.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49291, Q7XYY7, Q9AT76, Q9FPN8, Q9FPN9
      UniProtKB/TrEMBL
      A0A5S9WV19, A0A654ER95
      Conserved Domains (2) summary
      pfam01486
      Location:113 → 164
      K-box; K-box region
      cl00109
      Location:2 → 71
      MADS; MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type ...

    5. NM_001334765.1 → NP_001321572.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARA2

    6. NM_001334759.1 → NP_001321573.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARA1

    7. NM_001334760.1 → NP_001321574.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARE3, A0A5S9WV19

    8. NM_001334761.1 → NP_001321571.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARA9

    9. NM_180648.3 → NP_850979.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850979.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WV19
      Conserved Domains (2) summary
      pfam01486
      Location:109 → 160
      K-box; K-box region
      cl00109
      Location:2 → 61
      MADS; MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type ...

    10. NM_202431.2 → NP_974160.2  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974160.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WV19
      Conserved Domains (2) summary
      pfam01486
      Location:95 → 163
      K-box; K-box region
      cl00109
      Location:2 → 71
      MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...

    11. NM_180649.4 → NP_850980.2  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850980.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9AT76
      Conserved Domains (1) summary
      pfam01486
      Location:86 → 126
      K-box; K-box region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9AT76.1

    Gene LinkOut

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