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    ATRX P-loop containing nucleoside triphosphate hydrolases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837382, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATRX
    Official Full Name
    P-loop containing nucleoside triphosphate hydrolases superfamily protein
    Primary source
    TAIR:AT1G08600
    Locus tag
    AT1G08600
    See related
    Araport:AT1G08600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CHR20; F22O13.8; F22O13_8
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    Genomic context

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    See ATRX in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    28
    Sequence:
    Chromosome: 1; NC_003070.9 (2723677..2733613)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Leucine-rich receptor-like protein kinase family protein Neighboring gene ncRNA Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene ncRNA Neighboring gene Transcription factor jumonji (jmj) family protein / zinc finger (C5HC2 type) family protein Neighboring gene threonine aldolase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis ATRX Modulates H3.3 Occupancy and Fine-Tunes Gene Expression. Duc C, et al. Plant Cell, 2017 Jul. PMID 28684426, Free PMC Article
    2. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATRX is involved in H3.3 deposition and in adjusting genome expression.
      Title: Arabidopsis ATRX Modulates H3.3 Occupancy and Fine-Tunes Gene Expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001198009.1
    NM_001198010.1
    NM_100733.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone chaperone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within maintenance of rDNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    P-loop containing nucleoside triphosphate hydrolases superfamily protein
    NP_001184937.1
    • ATRX; FUNCTIONS IN: helicase activity, DNA binding, nucleic acid binding, ATP binding; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), SNF2-related (InterPro:IPR000330); BEST Arabidopsis thaliana protein match is: homolog of RAD54 (TAIR:AT3G19210.1).
    NP_001184938.1
    • ATRX; FUNCTIONS IN: helicase activity, DNA binding, ATP binding, nucleic acid binding; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), SNF2-related (InterPro:IPR000330); BEST Arabidopsis thaliana protein match is: homolog of RAD54 (TAIR:AT3G19210.1).
    NP_001184939.1
    • ATRX; FUNCTIONS IN: helicase activity, DNA binding, ATP binding, nucleic acid binding; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), SNF2-related (InterPro:IPR000330); BEST Arabidopsis thaliana protein match is: homolog of RAD54 (TAIR:AT3G19210.1).
    NP_172336.4
    • ATRX; FUNCTIONS IN: helicase activity, DNA binding, nucleic acid binding, ATP binding; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), SNF2-related (InterPro:IPR000330); BEST Arabidopsis thaliana protein match is: homolog of RAD54 (TAIR:AT3G19210.1); Has 31658 Blast hits to 23484 proteins in 2032 species: Archae - 346; Bacteria - 7271; Metazoa - 9089; Fungi - 4970; Plants - 2206; Viruses - 434; Other Eukaryotes - 7342 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2723677..2733613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198008.2 → NP_001184937.1  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184937.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HW51, F4HW52, O04048, Q9FRS5
      UniProtKB/TrEMBL
      A0A178VZQ9, A0A654ED47
      Conserved Domains (4) summary
      PRK02224
      Location:1 → 195
      PRK02224; DNA double-strand break repair Rad50 ATPase
      COG0553
      Location:647 → 1278
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd11726
      Location:481 → 575
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      cd18069
      Location:719 → 959
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4

    2. NM_100733.5 → NP_172336.4  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172336.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654ED47
      Conserved Domains (4) summary
      cd00046
      Location:749 → 885
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd11726
      Location:481 → 575
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:722 → 1020
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1093 → 1221
      Helicase_C; Helicase conserved C-terminal domain

    3. NM_001198009.1 → NP_001184938.1  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184938.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HW51, F4HW52, O04048, Q9FRS5
      UniProtKB/TrEMBL
      A0A178VZQ9, A0A654ED47
      Conserved Domains (4) summary
      PRK02224
      Location:1 → 195
      PRK02224; DNA double-strand break repair Rad50 ATPase
      COG0553
      Location:647 → 1278
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd11726
      Location:481 → 575
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      cd18069
      Location:719 → 959
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4

    4. NM_001198010.1 → NP_001184939.1  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184939.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HW51, F4HW52, O04048, Q9FRS5
      UniProtKB/TrEMBL
      A0A178VZQ9, A0A654ED47
      Conserved Domains (4) summary
      PRK02224
      Location:1 → 195
      PRK02224; DNA double-strand break repair Rad50 ATPase
      COG0553
      Location:647 → 1278
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd11726
      Location:481 → 575
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      cd18069
      Location:719 → 959
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4HW51.2

    Gene LinkOut

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