KNAT7 homeobox knotted-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: KNAT7
Official Full Name: homeobox knotted-like protein
Primary source: TAIR:AT1G62990
Locus tag: AT1G62990
See related: Araport:AT1G62990
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F16P17.16; F16P17_16; IRREGULAR XYLEM 11; IRX11; IXR11; KNOTTED-like homeobox of Arabidopsis thaliana 7; TRANSCRIPTION FACTOR KNAT7
Summary: Encodes a homeodomain transcription factor of the Knotted family. May be involved in secondary cell wall biosynthesis. Mutants have moderately irregular xylem development. Expression of this gene is upregulated by SND1 and MYB46.
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Genomic context

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See KNAT7 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 5

Sequence:: Chromosome: 1; NC_003070.9 (23337167..23340692)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Class II KNOX family members KNAT3 and KNAT7 redundantly participate in Arabidopsis seed coat mucilage biosynthesis.
Title: The Class II KNOX family members KNAT3 and KNAT7 redundantly participate in Arabidopsis seed coat mucilage biosynthesis.
The class II KNOX transcription factors KNAT3 and KNAT7 synergistically regulate monolignol biosynthesis in Arabidopsis.
Title: The class II KNOX transcription factors KNAT3 and KNAT7 synergistically regulate monolignol biosynthesis in Arabidopsis.
KNAT7 regulates xylan biosynthesis in Arabidopsis seed-coat mucilage.
Title: KNAT7 regulates xylan biosynthesis in Arabidopsis seed-coat mucilage.
The Class II KNOX genes KNAT3 and KNAT7 work cooperatively to influence deposition of secondary cell walls that provide mechanical support to Arabidopsis stems.
Title: The Class II KNOX genes KNAT3 and KNAT7 work cooperatively to influence deposition of secondary cell walls that provide mechanical support to Arabidopsis stems.
KNAT7 activates the promoters of the xylan biosynthetic genes, IRREGULAR XYLEM 9 (IRX9), IRX10, IRREGULAR XYLEM 14-LIKE (IRX14L), and FRAGILE FIBER 8 (FRA8).
Title: KNAT7 positively regulates xylan biosynthesis by directly activating IRX9 expression in Arabidopsis.
This study shows that OFP1 and OFP4 enhance the repression activity of BLH6, supporting a role for these OFPs as components of a putative multi-protein transcription regulatory complex containing BLH6 and KNAT7.
Title: A role for OVATE FAMILY PROTEIN1 (OFP1) and OFP4 in a BLH6-KNAT7 multi-protein complex regulating secondary cell wall formation in Arabidopsis thaliana.
BLH6 and KNAT7 bind to the REV promoter and repress REV expression.
Title: BEL1-LIKE HOMEODOMAIN6 and KNOTTED ARABIDOPSIS THALIANA7 interact and regulate secondary cell wall formation via repression of REVOLUTA.
KNAT7 is a negative regulator of secondary wall biosynthesis.
Title: The Class II KNOX gene KNAT7 negatively regulates secondary wall formation in Arabidopsis and is functionally conserved in Populus.
KNAT7 forms a functional complex with OFP proteins to regulate aspects of secondary cell wall formation.
Title: OVATE FAMILY PROTEIN4 (OFP4) interaction with KNAT7 regulates secondary cell wall formation in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_104977.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within mucilage biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mucilage extrusion from seed coat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of secondary cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seed coat development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seed growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within xylem development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: homeobox knotted-like protein

NP_564805.1

KNOTTED-like homeobox of Arabidopsis thaliana 7 (KNAT7); CONTAINS InterPro DOMAIN/s: ELK (InterPro:IPR005539), KNOX1 (InterPro:IPR005540), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), KNOX2 (InterPro:IPR005541), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: KNOTTED1-like homeobox gene 3 (TAIR:AT5G25220.1); Has 5187 Blast hits to 5186 proteins in 324 species: Archae - 0; Bacteria - 0; Metazoa - 1947; Fungi - 303; Plants - 2774; Viruses - 0; Other Eukaryotes - 163 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

23337167..23340692

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104977.3 → NP_564805.1 homeobox knotted-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564805.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8GXB5, Q8LG94, Q9FPQ8, Q9LQ05

UniProtKB/TrEMBL

A0A5S9WS26, A0A654EKI7

Conserved Domains (3) summary

pfam03790
Location:29 → 67

KNOX1; KNOX1 domain

pfam03791
Location:84 → 134

KNOX2; KNOX2 domain

pfam05920
Location:234 → 273

Homeobox_KN; Homeobox KN domain