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    Erv1 Erv1/Alr family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841411, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Erv1
    Official Full Name
    Erv1/Alr family protein
    Primary source
    TAIR:AT1G49880
    Locus tag
    AT1G49880
    See related
    Araport:AT1G49880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtErv1; EMB3106; EMBRYO DEFECTIVE 3106; F10F5.3; F10F5_3
    Summary
    Encodes Erv1, a component of the mitochondrial intermembrane space assembly machinery involved in the import pathway of the small intermembrane space proteins. It contains a Cys-X-Cys shuttle disulfide and oxidizes thioredoxin in vitro.
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    Genomic context

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    See Erv1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (18463998..18466085)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase (class phi) 14 Neighboring gene myosin-2 heavy chain-like protein Neighboring gene QWRF motif protein (DUF566) Neighboring gene C2H2 type zinc finger transcription factor family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Electron transfer reactivity of the Arabidopsis thaliana sulfhydryl oxidase AtErv1. Farver O, et al. J Biol Chem, 2009 Jan 23. PMID 19017646
    2. Gain of function in an ERV/ALR sulfhydryl oxidase by molecular engineering of the shuttle disulfide. Vitu E, et al. J Mol Biol, 2006 Sep 8. PMID 16893552
    3. Conserved and novel functions for Arabidopsis thaliana MIA40 in assembly of proteins in mitochondria and peroxisomes. Carrie C, et al. J Biol Chem, 2010 Nov 12. PMID 20829360, Free PMC Article
    4. Unique features of plant mitochondrial sulfhydryl oxidase. Levitan A, et al. J Biol Chem, 2004 May 7. PMID 14996837
    5. Erv1 of Arabidopsis thaliana can directly oxidize mitochondrial intermembrane space proteins in the absence of redox-active Mia40. Peleh V, et al. BMC Biol, 2017 Nov 8. PMID 29117860, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plant Erv1, unlike its homologs in fungi and animals, can promote protein import and oxidative protein folding in the IMS independently of the oxidoreductase Mia40.
      Title: Erv1 of Arabidopsis thaliana can directly oxidize mitochondrial intermembrane space proteins in the absence of redox-active Mia40.
    2. Data show taht insertional inactivation of Erv1 (AtErv1 At1g49880) leads to a lethal phenotype, inactivation of Mia40 (AtMia40 At5g23395) results in no detectable deleterious phenotype.
      Title: Conserved and novel functions for Arabidopsis thaliana MIA40 in assembly of proteins in mitochondria and peroxisomes.
    3. Mutants of AtErv1 lacking each of the three individual cysteine pairs were studied to determine the involvement of the respective disulfide groups in these reactions
      Title: Electron transfer reactivity of the Arabidopsis thaliana sulfhydryl oxidase AtErv1.
    4. Results describe the structure of Erv1, a sulfhydryl oxidase that contains a Cys-X4-Cys shuttle disulfide and oxidizes thioredoxin in vitro
      Title: Gain of function in an ERV/ALR sulfhydryl oxidase by molecular engineering of the shuttle disulfide.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_103875.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin-dependent sulfhydryl oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables thiol oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Erv1/Alr family protein
    NP_564557.1
    • Erv1/Alr family protein; FUNCTIONS IN: thiol oxidase activity; INVOLVED IN: oxidation reduction; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: ERV/ALR sulphydryl oxidase (InterPro:IPR017905), Erv1/Alr (InterPro:IPR006863); Has 843 Blast hits to 843 proteins in 218 species: Archae - 0; Bacteria - 1; Metazoa - 134; Fungi - 258; Plants - 61; Viruses - 64; Other Eukaryotes - 325 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18463998..18466085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333403.1 → NP_001320835.1  Erv1/Alr family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WGR9, A0A1P8AP23, A0A5S9WKH0, A0A7G2DWN6

    2. NM_103875.4 → NP_564557.1  Erv1/Alr family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564557.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GXX0, Q8LC15, Q9C6C6
      UniProtKB/TrEMBL
      A0A178WGR9, A0A5S9WKH0, A0A7G2DWN6
      Conserved Domains (1) summary
      pfam04777
      Location:82 → 169
      Evr1_Alr; Erv1 / Alr family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GXX0.1

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