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    THA2 threonine aldolase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819608, updated on 18-Sep-2024

    Summary

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    Official Symbol
    THA2
    Official Full Name
    threonine aldolase 2
    Primary source
    TAIR:AT3G04520
    Locus tag
    AT3G04520
    See related
    Araport:AT3G04520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    threonine aldolase 2
    Summary
    Encodes a threonine aldolase, involved in threonine degradation to glycine. Expressed in vascular tissue through out the plant.
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    Genomic context

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    See THA2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (1217174..1219847, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene LIGHT-DEPENDENT SHORT HYPOCOTYLS-like protein (DUF640) Neighboring gene tRNA-Arg Neighboring gene phosphoenolpyruvate carboxylase kinase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two Arabidopsis threonine aldolases are nonredundant and compete with threonine deaminase for a common substrate pool. Joshi V, et al. Plant Cell, 2006 Dec. PMID 17172352, Free PMC Article
    2. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001202878.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables threonine aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within threonine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    threonine aldolase 2
    NP_001189807.1
    • threonine aldolase 2 (THA2); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aromatic amino acid beta-eliminating lyase/threonine aldolase (InterPro:IPR001597), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: threonine aldolase 1 (TAIR:AT1G08630.4).
    NP_566228.1
    • threonine aldolase 2 (THA2); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aromatic amino acid beta-eliminating lyase/threonine aldolase (InterPro:IPR001597), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: threonine aldolase 1 (TAIR:AT1G08630.4); Has 4083 Blast hits to 4076 proteins in 1195 species: Archae - 22; Bacteria - 2430; Metazoa - 91; Fungi - 241; Plants - 97; Viruses - 0; Other Eukaryotes - 1202 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1217174..1219847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111323.4 → NP_566228.1  threonine aldolase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566228.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FPH3, Q9M835
      UniProtKB/TrEMBL
      A0A178VL48, A0A5S9X9C0, A0A654F421
      Conserved Domains (1) summary
      PLN02721
      Location:3 → 355
      PLN02721; threonine aldolase

    2. NM_001337534.1 → NP_001327633.1  threonine aldolase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FPH3, Q9M835
      UniProtKB/TrEMBL
      A0A178VL48, A0A5S9X9C0, A0A654F421
      Conserved Domains (1) summary
      PLN02721
      Location:3 → 355
      PLN02721; threonine aldolase

    3. NM_001202878.1 → NP_001189807.1  threonine aldolase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189807.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VL48, F4J4S1
      Conserved Domains (1) summary
      PLN02721
      Location:3 → 354
      PLN02721; threonine aldolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FPH3.1

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