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    UGD2 UDP-glucose 6-dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822594, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UGD2
    Official Full Name
    UDP-glucose 6-dehydrogenase family protein
    Primary source
    TAIR:AT3G29360
    Locus tag
    AT3G29360
    See related
    Araport:AT3G29360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    UDP-glucose dehydrogenase 2
    Summary
    Encodes one of four UDP-glucose dehydrogenase UGD) genes. Mutation of this gene in combination with UGD3 leads to swollen plant cell walls and severe developmental defects associated with changes in pectic polysaccharides.
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    Genomic context

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    See UGD2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (11267007..11269356, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene zinc finger (C2H2 type) family protein Neighboring gene histidine-containing phosphotransmitter 2 Neighboring gene miscRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of UDP-glucuronic acid biosynthesis leads to swollen plant cell walls and severe developmental defects associated with changes in pectic polysaccharides. Reboul R, et al. J Biol Chem, 2011 Nov 18. PMID 21949134, Free PMC Article
    2. Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls. Klinghammer M, et al. J Exp Bot, 2007. PMID 18057039
    3. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article
    4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035715.1
    NM_113861.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucose 6-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucose 6-dehydrogenase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UDP-glucuronate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-glucuronate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell wall pectin metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    UDP-glucose 6-dehydrogenase family protein
    NP_001030792.1
    • UDP-glucose 6-dehydrogenase family protein; FUNCTIONS IN: in 6 functions; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: UDP-glucose/GDP-mannose dehydrogenase, N-terminal (InterPro:IPR001732), 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), UDP-glucose/GDP-mannose dehydrogenase, dimerisation and substrate-binding domain (InterPro:IPR014028), UDP-glucose/GDP-mannose dehydrogenase, C-terminal (InterPro:IPR014027), NAD(P)-binding domain (InterPro:IPR016040), UDP-glucose/GDP-mannose dehydrogenase, dimerisation (InterPro:IPR014026), Nucleotide sugar dehydrogenase (InterPro:IPR017476); BEST Arabidopsis thaliana protein match is: UDP-glucose 6-dehydrogenase family protein (TAIR:AT5G39320.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_189582.1
    • UDP-glucose 6-dehydrogenase family protein; FUNCTIONS IN: in 6 functions; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: UDP-glucose/GDP-mannose dehydrogenase, N-terminal (InterPro:IPR001732), 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), UDP-glucose/GDP-mannose dehydrogenase, dimerisation and substrate-binding domain (InterPro:IPR014028), UDP-glucose/GDP-mannose dehydrogenase, C-terminal (InterPro:IPR014027), NAD(P)-binding domain (InterPro:IPR016040), UDP-glucose/GDP-mannose dehydrogenase, dimerisation (InterPro:IPR014026), Nucleotide sugar dehydrogenase (InterPro:IPR017476); BEST Arabidopsis thaliana protein match is: UDP-glucose 6-dehydrogenase family protein (TAIR:AT5G39320.1); Has 13454 Blast hits to 13430 proteins in 2148 species: Archae - 313; Bacteria - 7048; Metazoa - 213; Fungi - 99; Plants - 213; Viruses - 14; Other Eukaryotes - 5554 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      11267007..11269356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113861.4 → NP_189582.1  UDP-glucose 6-dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189582.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L8N1, Q944R8, Q9LIA8
      UniProtKB/TrEMBL
      A0A178VPC3, A0A5S9XH23
      Conserved Domains (4) summary
      PLN02353
      Location:1 → 473
      PLN02353; probable UDP-glucose 6-dehydrogenase
      pfam00984
      Location:210 → 305
      UDPG_MGDP_dh; UDP-glucose/GDP-mannose dehydrogenase family, central domain
      pfam03720
      Location:328 → 451
      UDPG_MGDP_dh_C; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
      pfam03721
      Location:3 → 184
      UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain

    2. NM_001035715.1 → NP_001030792.1  UDP-glucose 6-dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030792.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L8N1, Q944R8, Q9LIA8
      UniProtKB/TrEMBL
      A0A178VPC3, A0A5S9XH23
      Conserved Domains (4) summary
      PLN02353
      Location:1 → 473
      PLN02353; probable UDP-glucose 6-dehydrogenase
      pfam00984
      Location:210 → 305
      UDPG_MGDP_dh; UDP-glucose/GDP-mannose dehydrogenase family, central domain
      pfam03720
      Location:328 → 451
      UDPG_MGDP_dh_C; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
      pfam03721
      Location:3 → 184
      UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LIA8.1

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