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    TFIIIA transcription factor IIIA [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843536, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TFIIIA
    Official Full Name
    transcription factor IIIA
    Primary source
    TAIR:AT1G72050
    Locus tag
    AT1G72050
    See related
    Araport:AT1G72050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F28P5.6; F28P5_6; transcription factor IIIA
    Summary
    Encodes a transcriptional factor TFIIIA required for transcription of 5S rRNA gene. 5S rRNA is the smallest constituent of the ribosome. Work on one of the gene models AT1G72050.2 showed that it encodes a protein with nine Cys(2)-His(2)-type zinc fingers, a characteristic feature of TFIIIA proteins. AT1G72050.2 also contains a 23 amino acid spacer between fingers 1 and 2, a 66 amino acid spacer between fingers 4 and 5, and a 50 amino acid non-finger C-terminal tail. in vitro assay demonstrated that AT1g72050.2 binds to 5S rDNA and efficiently stimulates the transcription of 5S rRNA. AT1g72050.2 also binds to 5S rRNA in vitro. AT1g72050.2 is located at several nuclear foci including the nucleolus and is absent from the cytoplasm.
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    Genomic context

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    See TFIIIA in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (27115016..27117509)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene TonB-dependent heme receptor A Neighboring gene Acyl-CoA N-acyltransferases (NAT) superfamily protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene serine-type endopeptidase inhibitor Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcript levels, alternative splicing and proteolytic cleavage of TFIIIA control 5S rRNA accumulation during Arabidopsis thaliana development. Layat E, et al. Plant J, 2012 Jul. PMID 22353599
    2. Ribosomal protein L5 and transcription factor IIIA from Arabidopsis thaliana bind in vitro specifically Potato spindle tuber viroid RNA. Eiras M, et al. Arch Virol, 2011 Mar. PMID 21153748
    3. Identification and characterization of transcription factor IIIA and ribosomal protein L5 from Arabidopsis thaliana. Mathieu O, et al. Nucleic Acids Res, 2003 May 1. PMID 12711688, Free PMC Article
    4. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article
    5. MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays. Popescu SC, et al. Genes Dev, 2009 Jan 1. PMID 19095804, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptional and post-transcriptional control of TFIIIA transcripts as well as proteolytic cleavage of the TFIIIA protein regulate the quantities of 5S rRNA.
      Title: Transcript levels, alternative splicing and proteolytic cleavage of TFIIIA control 5S rRNA accumulation during Arabidopsis thaliana development.
    2. The authors show that Arabidopsis thaliana L5 and TFIIIA also bind potato spindle tuber viroid (+) RNA in vitro with the same affinity as they bind 5S rRNA, whereas the affinity for a chloroplastic viroid is significantly lower.
      Title: Ribosomal protein L5 and transcription factor IIIA from Arabidopsis thaliana bind in vitro specifically Potato spindle tuber viroid RNA.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001334513.1
    NM_001334514.1
    NM_105863.3
    NM_202399.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 5S rDNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5S rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor IIIA
    NP_565033.1
    • transcription factor IIIA (TFIIIA); FUNCTIONS IN: zinc ion binding, nucleic acid binding; INVOLVED IN: biological_process unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Zinc finger, C2H2-type (InterPro:IPR007087), Zinc finger, C2H2-type/integrase, DNA-binding (InterPro:IPR013087); BEST Arabidopsis thaliana protein match is: relative of early flowering 6 (TAIR:AT3G48430.1); Has 65581 Blast hits to 29235 proteins in 482 species: Archae - 0; Bacteria - 31; Metazoa - 61143; Fungi - 1878; Plants - 364; Viruses - 2; Other Eukaryotes - 2163 (source: NCBI BLink).
    NP_974128.1
    • transcription factor IIIA (TFIIIA); FUNCTIONS IN: 5S rRNA binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, 5S rDNA binding, nucleic acid binding; INVOLVED IN: biological_process unknown; LOCATED IN: nucleolus, nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Zinc finger, C2H2-type (InterPro:IPR007087), Zinc finger, C2H2-type/integrase, DNA-binding (InterPro:IPR013087); BEST Arabidopsis thaliana protein match is: relative of early flowering 6 (TAIR:AT3G48430.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27115016..27117509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105863.3 → NP_565033.1  transcription factor IIIA [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565033.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WFL7
      Conserved Domains (2) summary
      COG5048
      Location:2 → 275
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:129 → 151
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001334513.1 → NP_001322779.1  transcription factor IIIA [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AV27, A0A654EPR5

    3. NM_001334514.1 → NP_001322778.1  transcription factor IIIA [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AV34

    4. NM_202399.2 → NP_974128.1  transcription factor IIIA [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974128.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84MZ4, Q940P2, Q9C7G8
      UniProtKB/TrEMBL
      A0A654EPR5
      Conserved Domains (2) summary
      COG5048
      Location:51 → 363
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84MZ4.1

    Gene LinkOut

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