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    CLS cardiolipin synthase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825825, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLS
    Official Full Name
    cardiolipin synthase
    Primary source
    TAIR:AT4G04870
    Locus tag
    AT4G04870
    See related
    Araport:AT4G04870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cardiolipin synthase; T4B21.19; T4B21_19
    Summary
    Encodes a protein with cardiolipin synthase activity that is localized to the mitochondiria.
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    Genomic context

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    See CLS in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Sequence:
    Chromosome: 4; NC_003075.7 (2461674..2464150, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene K+ efflux antiporter 3 Neighboring gene ncRNA Neighboring gene DERLIN-2.2 Neighboring gene adenosine/AMP deaminase family protein Neighboring gene PCF11P-similar protein 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cardiolipin-mediated mitochondrial dynamics and stress response in Arabidopsis. Pan R, et al. Plant Cell, 2014 Jan. PMID 24443516, Free PMC Article
    2. The importance of cardiolipin synthase for mitochondrial ultrastructure, respiratory function, plant development, and stress responses in Arabidopsis. Pineau B, et al. Plant Cell, 2013 Oct. PMID 24151294, Free PMC Article
    3. Cardiolipin synthase of Arabidopsis thaliana. Nowicki M, et al. FEBS Lett, 2005 Apr 11. PMID 15811335
    4. Identification of an Arabidopsis thaliana gene for cardiolipin synthase located in mitochondria. Katayama K, et al. FEBS Lett, 2004 Nov 5. PMID 15527784
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLS is crucial for correct mitochondrial function and development in Arabidopsis under both optimal and stress conditions.
      Title: The importance of cardiolipin synthase for mitochondrial ultrastructure, respiratory function, plant development, and stress responses in Arabidopsis.
    2. Cardiolipin synthase [CLS]
      Title: Cardiolipin synthase of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_116725.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cardiolipin synthase (CMP-forming) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cardiolipin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cardiolipin synthase
    NP_567273.1
    • cardiolipin synthase (CLS); FUNCTIONS IN: phosphatidyltransferase activity, cardiolipin synthase activity; INVOLVED IN: phospholipid biosynthetic process; LOCATED IN: mitochondrion; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: CDP-alcohol phosphatidyltransferase (InterPro:IPR000462); BEST Arabidopsis thaliana protein match is: phosphatidylglycerolphosphate synthase 2 (TAIR:AT3G55030.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      2461674..2464150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116725.5 → NP_567273.1  cardiolipin synthase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567273.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LBT8, Q93YW7, Q9M0Z2, Q9ZS87
      UniProtKB/TrEMBL
      A0A178UW66
      Conserved Domains (2) summary
      PLN02794
      Location:1 → 341
      PLN02794; cardiolipin synthase
      COG0558
      Location:143 → 332
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93YW7.1

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