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    GRP2 glycine rich protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830024, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GRP2
    Official Full Name
    glycine rich protein 2
    Primary source
    TAIR:AT4G38680
    Locus tag
    AT4G38680
    See related
    Araport:AT4G38680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA COLD SHOCK PROTEIN 2; ATCSP2; COLD SHOCK DOMAIN PROTEIN 2; COLD SHOCK PROTEIN 2; CSDP2; CSP2; glycine rich protein 2; GRP-2; T9A14.9
    Summary
    Encodes a glycine-rich protein that binds nucleic acids and promotes DNA melting. Its transcript and protein levels are up-regulated in response to cold treatment with protein levels peaking earlier in shoots (~10-14 days) than in roots (~21 days). It is normally expressed in meristematic regions and developing tissues where cell division occurs. RNAi and antisense lines with lower levels of CSP2/GRP2 transcripts flower earlier than wild type plants and have some defects in anther and seed development.
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    Genomic context

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    See GRP2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (18071449..18073182, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Glycosyl hydrolase family 10 protein Neighboring gene Pathogenesis-related thaumatin superfamily protein Neighboring gene Pathogenesis-related thaumatin superfamily protein Neighboring gene PLC-like phosphodiesterases superfamily protein Neighboring gene Disease resistance-responsive (dirigent-like protein) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GRP2 proteins contain both CCHC zinc fingers and a cold shock domain. Kingsley PD, et al. Plant Cell, 1994 Nov. PMID 7827488, Free PMC Article
    2. AtGRP2, a cold-induced nucleo-cytoplasmic RNA-binding protein, has a role in flower and seed development. Fusaro AF, et al. Planta, 2007 May. PMID 17123099
    3. An RNA chaperone, AtCSP2, negatively regulates salt stress tolerance. Sasaki K, et al. Plant Signal Behav, 2015. PMID 26252779, Free PMC Article
    4. Arabidopsis cold shock domain protein 2 influences ABA accumulation in seed and negatively regulates germination. Sasaki K, et al. Biochem Biophys Res Commun, 2015 Jan 2. PMID 25475723
    5. Arabidopsis COLD SHOCK DOMAIN PROTEIN2 is a RNA chaperone that is regulated by cold and developmental signals. Sasaki K, et al. Biochem Biophys Res Commun, 2007 Dec 21. PMID 17963727

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data demonstrate that AtCSP2 acts as a negative regulator of salt stress tolerance in Arabidopsis.
      Title: An RNA chaperone, AtCSP2, negatively regulates salt stress tolerance.
    2. GRP2 influences ABA accumulation in seed and negatively regulates germination
      Title: Arabidopsis cold shock domain protein 2 influences ABA accumulation in seed and negatively regulates germination.
    3. Data indicate that AtGRP2 and AtGRP7 affected the expression of drought stress-responsive genes in transgenic rice.
      Title: Expression of Arabidopsis glycine-rich RNA-binding protein AtGRP2 or AtGRP7 improves grain yield of rice (Oryza sativa) under drought stress conditions.
    4. AtCSP2 negatively regulates freezing tolerance and is partially redundant with its closest paralog, AtCSP4.
      Title: Arabidopsis COLD SHOCK DOMAIN PROTEIN 2 is a negative regulator of cold acclimation.
    5. These data support the hypothesis that AtCSPs are involved in the transition to flowering and silique development in Arabidopsis.
      Title: Arabidopsis cold shock domain proteins: relationships to floral and silique development.
    6. CSDP2 overexpression accelerated the seed germination of Arabidopsis under salt stress.
      Title: Cold shock domain proteins affect seed germination and growth of Arabidopsis thaliana under abiotic stress conditions.
    7. The expression of GRP2 in flowers and seeds during development is reported.
      Title: AtGRP2, a cold-induced nucleo-cytoplasmic RNA-binding protein, has a role in flower and seed development.
    8. The functional roles of GRP2 in Arabidopsis thaliana under high-salinity, cold or osmotic stress are reported.
      Title: Functional characterization of a glycine-rich RNA-binding protein 2 in Arabidopsis thaliana under abiotic stress conditions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_120029.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in DNA duplex unwinding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA duplex unwinding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cold acclimation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to desiccation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within seed development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stamen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycine rich protein 2
    NP_195580.1
    • glycine rich protein 2 (GRP2); FUNCTIONS IN: double-stranded DNA binding, mRNA binding, single-stranded DNA binding, nucleic acid binding; INVOLVED IN: stamen development, vegetative to reproductive phase transition of meristem, response to cold, seed development, DNA duplex unwinding; LOCATED IN: nucleolus, nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 37 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Cold shock protein (InterPro:IPR011129), Cold-shock conserved site (InterPro:IPR019844), Zinc finger, CCHC-type (InterPro:IPR001878), Cold-shock protein, DNA-binding (InterPro:IPR002059); BEST Arabidopsis thaliana protein match is: glycine-rich protein 2B (TAIR:AT2G21060.1); Has 150401 Blast hits to 55289 proteins in 3379 species: Archae - 285; Bacteria - 51625; Metazoa - 48133; Fungi - 9113; Plants - 13783; Viruses - 1771; Other Eukaryotes - 25691 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      18071449..18073182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120029.3 → NP_195580.1  glycine rich protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195580.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2E8, Q41188
      UniProtKB/TrEMBL
      A0A178UYV3, A0A5S9Y217
      Conserved Domains (2) summary
      PTZ00368
      Location:131 → 201
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      pfam00313
      Location:11 → 77
      CSD; 'Cold-shock' DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q41188.1

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