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    GS2 glutamine synthetase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833535, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GS2
    Official Full Name
    glutamine synthetase 2
    Primary source
    TAIR:AT5G35630
    Locus tag
    AT5G35630
    See related
    Araport:AT5G35630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGSL1; GLN2; glutamine synthetase 2; GLUTAMINE SYNTHETASE 2; GLUTAMINE SYNTHETASE LIKE 1; MJE4.9; MJE4_9
    Summary
    chloroplastic glutamine synthetase
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    Genomic context

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    See GS2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (13830429..13833542)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Eukaryotic initiation factor 4E protein Neighboring gene Putative endonuclease or glycosyl hydrolase Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Excessive ammonium assimilation by plastidic glutamine synthetase causes ammonium toxicity in Arabidopsis thaliana. Hachiya T, et al. Nat Commun, 2021 Aug 16. PMID 34400629, Free PMC Article
    2. Validating the role of glutamine synthetase GLN2 during photorespiration in Arabidopsis thaliana. Kobercová E, et al. Plant Physiol, 2023 Dec 30. PMID 37787606, Free PMC Article
    3. Arabidopsis thaliana GLN2-encoded glutamine synthetase is dual targeted to leaf mitochondria and chloroplasts. Taira M, et al. Plant Cell, 2004 Aug. PMID 15273293, Free PMC Article
    4. Expression pattern of genes encoding nitrate and ammonium assimilating enzymes in Arabidopsis thaliana exposed to short term NaCl stress. Debouba M, et al. J Plant Physiol, 2013 Jan 15. PMID 23122335
    5. The glutamine synthetase gene family of Arabidopsis thaliana: light-regulation and differential expression in leaves, roots and seeds. Peterman TK, et al. Mol Gen Genet, 1991 Nov. PMID 1684022

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Validating the role of glutamine synthetase GLN2 during photorespiration in Arabidopsis thaliana.
      Title: Validating the role of glutamine synthetase GLN2 during photorespiration in Arabidopsis thaliana.
    2. Excessive ammonium assimilation by plastidic glutamine synthetase causes ammonium toxicity in Arabidopsis thaliana.
      Title: Excessive ammonium assimilation by plastidic glutamine synthetase causes ammonium toxicity in Arabidopsis thaliana.
    3. ACR11 is an activator of GS2.
      Title: ACR11 is an Activator of Plastid-Type Glutamine Synthetase GS2 in Arabidopsis thaliana.
    4. Drop in mRNA levels for GLN2 and GLN1 by salt was associated with a similar inhibition of glutamine synthetase activity in leaves of Arabidopsis thaliana. In roots, NaCl stress was found to enhance mRNA levels of GLN2 and cytosolic-encoding genes.
      Title: Expression pattern of genes encoding nitrate and ammonium assimilating enzymes in Arabidopsis thaliana exposed to short term NaCl stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_001036892.1
    NM_001085170.1
    NM_122954.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glutamine synthetase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamine synthetase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables salicylic acid binding HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ammonia assimilation cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in glutamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 
    located_in thylakoid HDA PubMed 

    General protein information

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    Preferred Names
    glutamine synthetase 2
    NP_001031969.1
    • glutamine synthetase 2 (GS2); FUNCTIONS IN: glutamate-ammonia ligase activity; INVOLVED IN: in 8 processes; LOCATED IN: in 7 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine synthetase, catalytic domain (InterPro:IPR008146), Glutamine synthetase, beta-Grasp (InterPro:IPR008147), Glutamine synthetase/guanido kinase, catalytic domain (InterPro:IPR014746); BEST Arabidopsis thaliana protein match is: glutamine synthase clone F11 (TAIR:AT1G66200.1); Has 8236 Blast hits to 8234 proteins in 2572 species: Archae - 144; Bacteria - 3324; Metazoa - 415; Fungi - 259; Plants - 1746; Viruses - 3; Other Eukaryotes - 2345 (source: NCBI BLink).
    NP_001078639.1
    • glutamine synthetase 2 (GS2); FUNCTIONS IN: glutamate-ammonia ligase activity; INVOLVED IN: in 8 processes; LOCATED IN: in 6 components; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine synthetase, catalytic domain (InterPro:IPR008146), Glutamine synthetase, beta-Grasp (InterPro:IPR008147), Glutamine synthetase/guanido kinase, catalytic domain (InterPro:IPR014746); BEST Arabidopsis thaliana protein match is: glutamine synthase clone F11 (TAIR:AT1G66200.1); Has 8236 Blast hits to 8234 proteins in 2572 species: Archae - 144; Bacteria - 3324; Metazoa - 415; Fungi - 259; Plants - 1746; Viruses - 3; Other Eukaryotes - 2345 (source: NCBI BLink).
    NP_198413.1
    • glutamine synthetase 2 (GS2); FUNCTIONS IN: glutamate-ammonia ligase activity; INVOLVED IN: in 8 processes; LOCATED IN: in 9 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine synthetase, catalytic domain (InterPro:IPR008146), Glutamine synthetase, beta-Grasp (InterPro:IPR008147), Glutamine synthetase/guanido kinase, catalytic domain (InterPro:IPR014746); BEST Arabidopsis thaliana protein match is: glutamine synthase clone F11 (TAIR:AT1G66200.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      13830429..13833542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122954.4 → NP_198413.1  glutamine synthetase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198413.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q43127
      UniProtKB/TrEMBL
      A0A178UUP0, A0A384L697, B9DGD1
      Conserved Domains (1) summary
      PLN03036
      Location:1 → 430
      PLN03036; glutamine synthetase; Provisional

    2. NM_001085170.1 → NP_001078639.1  glutamine synthetase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078639.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q43127
      UniProtKB/TrEMBL
      A0A178UUP0, A0A384L697, B9DGD1
      Conserved Domains (1) summary
      PLN03036
      Location:1 → 430
      PLN03036; glutamine synthetase; Provisional

    3. NM_001036892.1 → NP_001031969.1  glutamine synthetase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031969.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q43127
      UniProtKB/TrEMBL
      A0A178UUP0, A0A384L697, B9DGD1
      Conserved Domains (1) summary
      PLN03036
      Location:1 → 430
      PLN03036; glutamine synthetase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q43127.1

    Gene LinkOut

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